The Transesterification of Hickory Nuts into Biodiesel Fuel

• Biodiesel fuels can be produced from a fat and an alcohol via transesterification • Hickory nuts have a high fat content (~60 % by weight) • Can nuts from shagbark hickory (Carya ovata) be used to produce a biodiesel fuel using existing acidcatalyzed transesterification methods

Theory for the Secondary Eclipse Fluxes, Spectra, Atmospheres, and Light Curves of Transiting Extrasolar Giant Planets

We have created a general methodology for calculating the wavelength-dependent light curves of close-in extrasolar giant planets (EGPs) as they traverse their orbits. Focussing on the transiting EGPs HD189733b, TrES-1, and HD209458b, we calculate planet/star flux ratios during secondary eclipse and compare them with the Spitzer data points obtained so far in the mid-infrared. We introduce a simple parametrization for the redistribution of heat to the planet's nightside, derive constraints on this parameter (P_n), and provide a general set of predictions for planet/star contrast ratios as a function of wavelength, model, and phase. Moreover, we calculate average dayside and nightside atmospheric temperature/pressure profiles for each transiting planet/P_n pair with which existing and anticipated Spitzer data can be used to probe the atmospheric thermal structure of severely irradiated EGPs. We find that the baseline models do a good job of fitting the current secondary eclipse dataset, but that the Spitzer error bars are not yet small enough to discriminate cleanly between all the various possibilities.Comment: 14 figures, 7 text pages (in two-column emulateapj format); Accepted to the Ap.J. June 26, 2006; one cosmetic change made to astro-ph version

Phase Functions and Light Curves of Wide Separation Extrasolar Giant Planets

We calculate self-consistent extrasolar giant planet (EGP) phase functions and light curves for orbital distances ranging from 0.2 AU to 15 AU. We explore the dependence on wavelength, cloud condensation, and Keplerian orbital elements. We find that the light curves of EGPs depend strongly on wavelength, the presence of clouds, and cloud particle sizes. Furthermore, the optical and infrared colors of most EGPs are phase-dependent, tending to be reddest at crescent phases in $V-R$ and $R-I$. Assuming circular orbits, we find that at optical wavelengths most EGPs are 3 to 4 times brighter near full phase than near greatest elongation for highly-inclined (i.e., close to edge-on) orbits. Furthermore, we show that the planet/star flux ratios depend strongly on the Keplerian elements of the orbit, particularly inclination and eccentricity. Given a sufficiently eccentric orbit, an EGP's atmosphere may make periodic transitions from cloudy to cloud-free, an effect that may be reflected in the shape and magnitude of the planet's light curve. Such elliptical orbits also introduce an offset between the time of the planet's light curve maximum and the time of full planetary phase, and for some sets of orbital parameters, this light curve maximum can be a steeply increasing function of eccentricity. We investigate the detectability of EGPs by proposed space-based direct-imaging instruments.Comment: submitted to Astrophysical Journa

Detection of Earth-like Planets Using Apodized Telescopes

The mission of NASA's Terrestrial Planet Finder (TPF) is to find Earth-like planets orbiting other stars and characterize the atmospheres of these planets using spectroscopy. Because of the enormous brightness ratio between the star and the reflected light from the planet, techniques must be found to reduce the brightness of the star. The current favorite approach to doing this is with interferometry: interfering the light from two or more separated telescopes with a $\pi$ phase shift, nulling out the starlight. While this technique can, in principle, achieve the required dynamic range, building a space interferometer that has the necessary characteristics poses immense technical difficulties. In this paper, we suggest a much simpler approach to achieving the required dynamic range. By simply adjusting the transmissive shape of a telescope aperture, the intensity in large regions around the stellar image can be reduced nearly to zero. This approach could lead to construction of a TPF using conventional technologies, requiring space optics on a much smaller scale than the current TPF approach.Comment: Accepted for publication in ApJ Letters, 9 pages, 6 figure

Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands

Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis. Two pyrrole-imidazole polyamides were designed to bind DNA sequences immediately adjacent to binding sites for the transcription factors Ets-l, lymphoid-enhancer binding factor 1, and TATA-box binding protein. These synthetic ligands specifically inhibit DNA-binding of each transcription factor and HIV type 1 transcription in cell-free assays. When used in combination, the polyamides inhibit virus replication by >99% in isolated human peripheral blood lymphocytes, with no detectable cell toxicity, The ability of small molecules to target predetermined DNA sequences located within RNA polymerase II promoters suggests a general approach for regulation of gene expression, as well as a mechanism for the inhibition of viral replication

Phase light curves for extrasolar Jupiters and Saturns

We predict how a remote observer would see the brightness variations of giant planets similar to Jupiter and Saturn as they orbit their central stars. We model the geometry of Jupiter, Saturn and Saturn's rings for varying orbital and viewing parameters. Scattering properties for the planets and rings at wavelenghts 0.6-0.7 microns follow Pioneer and Voyager observations, namely, planets are forward scattering and rings are backward scattering. Images of the planet with or without rings are simulated and used to calculate the disk-averaged luminosity varying along the orbit, that is, a light curve is generated. We find that the different scattering properties of Jupiter and Saturn (without rings) make a substantial difference in the shape of their light curves. Saturn-size rings increase the apparent luminosity of the planet by a factor of 2-3 for a wide range of geometries. Rings produce asymmetric light curves that are distinct from the light curve of the planet without rings. If radial velocity data are available for the planet, the effect of the ring on the light curve can be distinguished from effects due to orbital eccentricity. Non-ringed planets on eccentric orbits produce light curves with maxima shifted relative to the position of the maximum planet's phase. Given radial velocity data, the amount of the shift restricts the planet's unknown orbital inclination and therefore its mass. Combination of radial velocity data and a light curve for a non-ringed planet on an eccentric orbit can also be used to constrain the surface scattering properties of the planet. To summarize our results for the detectability of exoplanets in reflected light, we present a chart of light curve amplitudes of non-ringed planets for different eccentricities, inclinations, and the viewing azimuthal angles of the observer.Comment: 40 pages, 13 figures, submitted to Ap.

Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression

The glucocorticoid receptor (GR) affects the transcription of genes involved in diverse processes, including energy metabolism and the immune response, through DNA-binding dependent and independent mechanisms. The DNA-binding dependent mechanism occurs by direct binding of GR to glucocorticoid response elements (GREs) at regulatory regions of target genes. The DNA-binding independent mechanism involves binding of GR to transcription factors and coactivators that, in turn, contact DNA. A small molecule that competes with GR for binding to GREs could be expected to affect the DNA-dependent pathway selectively by interfering with the protein-DNA interface. We show that a DNA-binding polyamide that targets the consensus GRE sequence binds the glucocorticoid-induced zipper (GILZ) GRE, inhibits expression of GILZ and several other known GR target genes, and reduces GR occupancy at the GILZ promoter. Genome-wide expression analysis of the effects of this polyamide on a set of glucocorticoid-induced and -repressed genes could help to elucidate the mechanism of GR regulation for these genes

In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography

The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor-DNA interfaces, and modulate gene expression pathways in cell culture experiments. The 18F-radiolabeled polyamides were prepared by oxime ligation between 4-[18F]-fluorobenzaldehyde and a hydroxylamine moiety at the polyamide C terminus. Small animal PET imaging of radiolabeled polyamides administered to mice revealed distinct differences in the biodistribution of a 5-ring β-linked polyamide versus an 8-ring hairpin, which exhibited better overall bioavailability. In vivo imaging of pyrrole-imidazole polyamides by PET is a minimum first step toward the translation of polyamide-based gene regulation from cell culture to small animal studies