Desarrollo y aplicación de la Terapia Asistida por Animales en el hospital universitario

This report refers to the experience of the Board of Nursing of Hospital São Paulo, Universidade de São Paulo, in the development and implantation of Animal-Assisted Therapy, as one of its projects humanization of hospital: Projeto Amicão. Aiming to offer patients a positive experience that differs from the routine of the hospital environment, some units of the Hospiral São Paulo received the visit of an animal for sessions of Animal-Assiste Therapy. The results achieved among patients and its companions and health professionals were positive, in addition to arouse the attention and the interest of other health institutions and the media. It is thus evidenced the importance of reporting the experience of Projeto Amicão in the hospital.Este informe se refiere a la experiencia de la Junta de Enfermería, Hospital de São Paulo (HSP), Universidad Federal de São Paulo en el desarrollo y el despliegue de la Terapia Asistida por Animales (TAA), como uno de sus proyectos de humanización del hospital: Proyecto Amicão. Con la finalidad de ofrecer los pacientes una experiencia positiva que difiere de la rutina del entorno hospitalario, algunas unidades de lo HSP recibió la visita de un animal para los períodos de sesiones de TAA. Los logros entre los pacientes, sus acompañantes y profesionales de la salud fueron positivos, y despertó la atención y el interés de otras instituciones de salud y de los medios de comunicación. Es así de relieve la importancia de comunicar la experiencia del Proyecto Amicão en el hospital.O presente relato refere-se à experiência da Diretoria de Enfermagem do Hospital São Paulo da Universidade Federal de São Paulo (UNIFESP) no desenvolvimento e implantação da Terapia Assistida por Animais, como um de seus projetos de humanização hospitalar: Projeto Amicão. Objetivando proporcionar aos pacientes uma experiência positiva que difere da rotina do ambiente hospitalar, algumas unidades do Hospital São Paulo receberam a visita de um animal para sessões de Terapia Assistida por Animais. Os resultados alcançados entre pacientes, acompanhantes e profissionais da saúde foram positivos, além de despertar a atenção e o interesse de outras instituições de saúde e da mídia. Ficou, assim, evidenciada a importância de se relatar a experiência do Projeto Amicão no ambiente hospitalar.Universidade Federal de São Paulo (UNIFESP) Hospital São Paulo Departamento de EnfermagemCentro Universitário São CamiloUNIFESP, Hospital São Paulo Depto. de EnfermagemSciEL

MITSuME--Multicolor Imaging Telescopes for Survey and Monstrous Explosions

Development of MITSuME is reported. Two 50-cm optical telescopes have been built at Akeno in Yamanashi prefecture and at Okayama Astrophysical Observatory (OAO) in Okayama prefecture. Three CCD cameras for simultaneous g'RcIc photometry are to be mounted on each focal plane, covering a wide FOV of about 30" x 30". The limiting magnitude at V is fainter than 18. In addition to these two optical telescopes, a 91-cm IR telescope with a 1 deg x 1 deg field of view is being built at OAO, which performs photometry in YJHK bands. These robotic telescopes can start the observation of counterparts of a GRB within a minute from an alert. We aim to obtain photometric redshifts exceeding 10 with these telescopes. The performance and the current construction status of the telescopes are presented.Comment: 4 pages, 3 figures, 4th Workshop on Gamma-Ray Burst in the Afterglow Era, Roma, October 18-22, 200

Neat and Aqueous Polyelectrolytes under a Steady-Shear Flow

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Cultural trauma, counter-narratives, and dialogical intellectuals: the works of Murakami Haruki and Mori Tatsuya in the context of the Aum affair

In this article, we offer a new conceptualization of intellectuals as carriers of cultural trauma through a case study of the Aum Affair, a series of crimes and terrorist attacks committed by the Japanese new religious movement Aum Shinrikyō. In understanding the performative roles intellectuals play in trauma construction, we offer a new dichotomy between “authoritative intellectuals,” who draw on their privileged parcours and status to impose a distinct trauma narrative, and “dialogical intellectuals,” who engage with local actors dialogically to produce polyphonic and open-ended trauma narratives. We identify three dimensions of dialogical intellectual action: firstly, the intellectuals may be involved in dialogue with local participants; secondly, the intellectual products themselves may be dialogical in content; and thirdly, there might be a concerted effort on the part of the intellectuals to record and to disseminate dialogue between local participants. In the context of the Aum Affair, we analyze the works of Murakami Haruki and Mori Tatsuya as dialogical intellectuals while they sought, with the help of local actors’ experiences, to challenge and to alter the orthodox trauma narrative of Aum Shinrikyō as exclusively a social evil external to Japanese society and an enemy to be excluded from it. Towards the end of the article, we discuss the broader significance of this case study and suggest that in light of recent societal and technological developments, the role and scope of dialogical intellectuals as carriers of trauma are changing and possibly expanding

Attributing weather patterns to Davao River extreme rainfall from Reanalysis and GCM

Extreme rainfall or heavy rainfall events (HREs) causes significant socio-economic damages annually affecting local development especially in developing countries. Thus, assessing changes in frequency and magnitude of HREs under climate change using global climate model (GCM) projections became ubiquitous to hydrological impact studies. Here, we present a framework for evaluating GCM's ability in reproducing the seasonal frequency of HREs in Davao River basin and the associated weather patterns that led to HREs. Our results show that HREs in MRI-AGCM 3.2S occurred 81 % in DJF and 4 % in JJA, which showed over(under) estimation bias during DJF(JJA) season compared to ERA5 HREs that show occurrence of 50 % in DJF and 18 % in JJA. Furthermore, we examined the weather pattern and anomalies that led to anomalous conditions of the season specific HREs in Davao River basin, which showed MRI-AGCM3.2S was able to reproduce the general structure of anomalous conditions fairly well on both seasons in comparison with ERA5. However, the slight over(under)estimation of the surface anomalous conditions in DJF(JJA) are directly proportional to the over(under)estimation in rainfall magnitude in the basin.</p

Assessment of flood damage to agricultural crops under climate change scenarios using MRI-AGCM outputs in the Solo River basin of Indonesia

Understanding the effects of climate change on agricultural crops is an essential part of flood-risk management and adaptation measures. However, the quantitative impact of flood damage on agricultural crops under climate change is still not clearly understood. It is thus crucial to investigate flood damage to agricultural crops under climate change scenarios to understand future crop damage better. In this study, we first explored the relationship between extreme rainfall and damaged paddy area for a historical period, and then focused on the quantitative analysis of flood impact on rice crops under climate change using MRI-AGCM3.2S climate model outputs for the past (1979–2002) and future (2075–2098) climate periods for the Solo River basin in Indonesia. We developed a quantitative damage assessment method by coupling water and energy budget-based rainfall-runoff-inundation model outputs and a flood loss model. Flood damage to rice crops was defined as a function of flood depth and duration, and depth-duration-damage curves were applied to quantify the damage. The results show that flood damage to rice crops will be more severe in the future than in the past, and the findings can be useful in establishing risk reduction and adaptation measures.</p

The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-κB transcriptional activity in models of rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease that produces synovial proliferation and joint erosions. The pathologic lesions of RA are driven through the production of inflammatory mediators in the synovium mediated, in part, by the transcription factor NF-κB. We have identified a non-steroidal estrogen receptor ligand, WAY-169916, that selectively inhibits NF-κB transcriptional activity but is devoid of conventional estrogenic activity. The activity of WAY-169916 was monitored in two models of arthritis, the HLA-B27 transgenic rat and the Lewis rat adjuvant-induced model, after daily oral administration. In both models, a near complete reversal in hindpaw scores was observed as well as marked improvements in the histological scores. In the Lewis rat adjuvant model, WAY-169916 markedly suppresses the adjuvant induction of three serum acute phase proteins: haptoglobin, α1-acid glycoprotein (α1-AGP), and C-reactive protein (CRP). Gene expression experiments also demonstrate a global suppression of adjuvant-induced gene expression in the spleen, liver, and popliteal lymph nodes. Finally, WAY-169916 was effective in suppressing tumor necrosis factor-α-mediated inflammatory gene expression in fibroblast-like synoviocytes isolated from patients with RA. Together, these data suggest the utility of WAY-169916, and other compounds in its class, in treating RA through global suppression of inflammation via selective blockade of NF-κB transcriptional activity

Absorption and distribution of etoricoxib in plasma, CSF, and wound tissue in patients following hip surgery—a pilot study

The perioperative administration of selective cyclooxygenase-2 (COX-2)-inhibitors to avoid postoperative pain is an attractive option: they show favorable gastro-intestinal tolerability, lack inhibition of blood coagulation, and carry a low risk of asthmatic attacks. The purpose of this study was to determine the cerebrospinal fluid (CSF), plasma, and tissue pharmacokinetics of orally administered etoricoxib and to compare it with effect data, i.e., COX-2-inhibition in patients after hip surgery. The study was performed in a blinded, randomized, parallel group design. A total of 12 adult patients were included who received 120 mg etoricoxib (n = 8) or placebo (n = 4) on day 1 post-surgery. Samples from plasma, CSF, and tissue exudates were collected over a period of 24 h post-dosing and analyzed for etoricoxib and prostaglandin E2 (PGE2) using liquid chromatography-tandem mass spectrometry and immuno-assay techniques. CSF area under the curve (AUC) [AUCs(O–24h)] for etoricoxib amounted to about 5% of the total AUC in plasma (range: 2–7%). Individual CSF lag times with respect to (50%) peak plasma concentration were ≤2 h in all but one case (median: 1 h). PGE2 production in tissue was significantly blocked by the COX-2 inhibitor starting with the appearance of etoricoxib in tissue and lasting for the whole observation period of 24 h (P < 0.01). In conclusion, etoricoxib reaches the CSF and site of surgery at effective concentrations and reduces PGE2 production at the presumed site of action