Complex Dielectric Coefficient of Breast Phantom Prepared for Breast Cancer Detection

Microwave measurement techniques attract attention due to its practical solutions in breast cancer imaging. Early detection of cancer is the purpose of these imaging studies. For these imaging processes, phantoms which reflect the properties of the area to be imaged are produced. The produced homogeneous phantoms are imaged by stepper frequency of radar technology, as the narrow bands are used for heterogeneous mixtures. Phantoms are used since 70's until today. Different methods are experimented for producing phantoms of tissue, muscle, fat, skin, etc. Iron powder, polymer materials, various oils and gelatins used today are the materials used for producing the phantoms. In this study, phantom breast imaging is aimed. Phantoms breast and breast tumor samples are created. For phantoms and tumor samples, reflection and transmittion measurements are done with Network Analyzer in X-Band (8.2-12.4 GHz). Complex permittivity is calculated with Agilent 85071 Material Measurement Software-Fast Method (NIST-iterative method). It was considered breast phantom with tumor model for 3D imagine at 2-3.5 GHz frequency range

Lipoprotein lipase gene polymorphism and lipid profile in coronary artery disease

Context.-Lipoprotein lipase (LPL) plays a central role in lipid metabolism, hydrolyzing triglyceride in chylomicrons and very-low-density lipoproteins. The PvuII polymorphic variant of LPL gene is common and might affect risk of coronary artery disease (CAD)

Lipoprotein Lipase Gene Polymorphism and Lipid Profile in Coronary Artery Disease

Abstract Context.—Lipoprotein lipase (LPL) plays a central role in lipid metabolism, hydrolyzing triglyceride in chylomicrons and very-low-density lipoproteins. The PvuII polymorphic variant of LPL gene is common and might affect risk of coronary artery disease (CAD). Objective.—Our aim was to determine whether LPL– PvuII polymorphism can be considered to be an independent risk factor or a predictor for CAD in Turkish subjects. Design.—We used polymerase chain reaction and restriction enzyme digestion to determine the distribution of the previously described C→T transition that causes a PvuII polymorphism in intron 6 among healthy blood donors of Turkish origin and among angiographically confirmed CAD patients with comparable ethnic backgrounds. Results.—For the PvuII genotypes, within the CAD group (n = 80), the +/− genotype was found in 39 individuals (48.8%), whereas 25 (31.3%) carried the +/+ genotype, and 14 (17.5%) carried the −/− genotype. Within the control group (n = 49), the −/− genotype was found in 19 individuals (38.8%), 16 (32.7%) carried the +/− genotype, and 14 (28.6%) carried the +/+ genotype. The genotype frequency distribution was significantly different (P = .049) in the CAD and control study groups. The most frequent genotype among CAD patients was +/−; this genotype was more frequent in patients than in control subjects. However, the −/− genotype was more prevalent in the control group. Lipoprotein lipase–PvuII polymorphism was found to be associated with fasting total cholesterol and low-density lipoprotein cholesterol levels. The +/+ genotype was found to have higher levels of total cholesterol and low-density lipoprotein cholesterol in both the CAD and control groups. Conclusion.—There was a difference in the distribution of LPL–PvuII genotypes between the healthy subjects and the patients with CAD. Lipoprotein lipase–PvuII polymorphisms were not detected as independent risk factors for CAD in this study group, but had associations with lipid levels.</jats:p