Adaptive Mesh Refinement for Hyperbolic Systems based on Third-Order Compact WENO Reconstruction

In this paper we generalize to non-uniform grids of quad-tree type the Compact WENO reconstruction of Levy, Puppo and Russo (SIAM J. Sci. Comput., 2001), thus obtaining a truly two-dimensional non-oscillatory third order reconstruction with a very compact stencil and that does not involve mesh-dependent coefficients. This latter characteristic is quite valuable for its use in h-adaptive numerical schemes, since in such schemes the coefficients that depend on the disposition and sizes of the neighboring cells (and that are present in many existing WENO-like reconstructions) would need to be recomputed after every mesh adaption. In the second part of the paper we propose a third order h-adaptive scheme with the above-mentioned reconstruction, an explicit third order TVD Runge-Kutta scheme and the entropy production error indicator proposed by Puppo and Semplice (Commun. Comput. Phys., 2011). After devising some heuristics on the choice of the parameters controlling the mesh adaption, we demonstrate with many numerical tests that the scheme can compute numerical solution whose error decays as $\langle N\rangle^{-3}$, where $\langle N\rangle$ is the average number of cells used during the computation, even in the presence of shock waves, by making a very effective use of h-adaptivity and the proposed third order reconstruction.Comment: many updates to text and figure

Ruptures and repairs of group therapy alliance. an untold story in psychotherapy research

Although previous studies investigated the characteristics of therapeutic alliance in group treatments, there is still a dearth of research on group alliance ruptures and repairs. The model by Safran and Muran was originally developed to address therapeutic alliance in individual therapies, and the usefulness of this approach to group intervention needs to be demonstrated. Alliance ruptures are possible at member to therapist, member to member, member to group levels. Moreover, repairs of ruptures in group are quite complex, i.e., because other group members have to process the rupture even if not directly involved. The aim of the current study is to review the empirical research on group alliance, and to examine whether the rupture repair model can be a suitable framework for clinical understanding and research of the complexity of therapeutic alliance in group treatments. We provide clinical vignettes and commentary to illustrate theoretical and research aspects of therapeutic alliance rupture and repair in groups. Our colleague Jeremy Safran made a substantial contribution to research on therapeutic alliance, and the current paper illustrates the enduring legacy of this work and its potential application to the group therapy context

The effects of tides on swash statistics on an intermediate beach

Swash hydrodynamics were investigated on an intermediate beach using runup data obtained from video images. Under mild, near-constant, offshore wave conditions, the presence of a sandbar and the tidally controlled water depth over its crest determined whether most of the incoming waves broke before reaching the shoreline. This forced a change in the pattern of wave energy dissipation across the surf zone between low and high tide, which was reflected by changes to swash on time scales of a few hours. Significant runup height (Rs, defined as 4 times the standard deviation of the waterline time series), was found to vary by a factor of 2 between low tide, when most of the waves were breaking over the sandbar (Rs/Hs ≈ 1.5, where Hs is the offshore significant wave height) and high tide, when the waves were barely breaking (Rs/Hs ≈ 2.7). The increase in wave energy dissipation during low tide was also associated with changes in swash maxima distribution, a decrease in mean swash period, and increasing energy at infragravity frequencies. Bispectral analysis suggested that this infragravity modulation might have been connected with the presence of secondary waves

Imatinib-mesylate for all patients with hypereosinophilic syndrome?

Some recent papers have focused on the activity of imatinib-mesylate, a selective inhibitor of tyrosine kinase, in idiopathic hypereosinophilic syndrome (HES) [1], [2], [3] and [4]. In this setting, a possible therapeutic target was identified by Cools et al. [2], who described the fusion tyrosine-kinase gene FIP1L1/PDGFRA as the result of an interstitial deletion within chromosome 4 in nine out of sixteen (56%) patients affected by HES. Of interest, although in this study the response to imatinib was strictly correlated with the presence of FIP1L1/PDGFRA rearrangement (all patients with such a molecular lesion treated with imatinib responded), only five out of nine responding patients evidenced the abnormal transcript [2]. Among the possible alternative mechanisms for the activation of the PDGFRA tyrosine-kinase domain, these authors suggested there may be a different fusion gene

Short-range correlations in low-lying nuclear excited states

The electromagnetic transitions to various low-lying excited states of 16O, 48Ca and 208Pb are calculated within a model which considers the short-range correlations. In general the effects of the correlations are small and do not explain the required quenching to describe the data.Comment: 6 pages, 2 postscript figures, 1 tabl

SENSE: A comparison of photon detection efficiency and optical crosstalk of various SiPM devices

This paper describes a comparison of photon detection efficiency and optical crosstalk measurements performed by three partners: Geneva University, Catania Observatory and Nagoya University. The measurements were compared for three different SiPM devices with different active areas: from 9 $mm^2$ up to 93.6 $mm^2$ produced by Hamamatsu. The objective of this work is to establish the measurements and analysis procedures for calculating the main SiPM parameters and their precision. This work was done in the scope of SENSE project which aims to build roadmap for the last developments in field of sensors for low light level detection

Blastocystis spp.: avances, controversias y desafíos futuros

Blastocystis spp. es el protista intracelular que se detecta con mayor frecuencia en muestras de materia fecal humana; las tasas de infección pueden superar el 20% en países en vías de desarrollo. El hallazgo de este parásito en heces de diversas especies animales sugiere su potencial zoonótico. La relevancia clínica y el papel patógeno de Blastocystis spp. en el tracto intestinal son inciertos. Varias son las publicaciones que lo reconocen como agente etiológico de desórdenes intestinales como diarrea, enfermedad inflamatoria intestinal y colitis ulcerosa, aunque la patogenicidad de este parásito no ha sido probada. Este amplio rango de respuestas a la infección podría estar relacionado con la diversidad genética de los aislamientos provenientes de hospedadores infectados.In developing countries, infection rates are higher than 20%. The presence of this parasite in the feces of several host species suggests its zoonotic potential. The clinical relevance and the pathogenic role of Blastocystis spp. in the intestinal tract remain unclear. There are several clinical reports that recognize it as the etiologic agent of several intestinal disorders such as diarrhea, inflammatory bowel disease and ulcerative colitis, although the pathogenicity of this parasite has not been proved yet. This wide range of clinical manifestations could be related to the genetic diversity exhibited by this parasite