Formation en radioprotection du personnel des entreprises intervenant en centrale nucléaire

Depuis plus de 10 ans, les A.P.A.V.E. ont entrepris, à la demande de leurs adhérents, des actions de formation en radioprotection dans le prolongement de leurs activités de contrôle des sources de rayonnements ionisants en milieu industriel comme en milieu médical. C’est donc du fait de cette expérience que les A.P.A.V.E. ont été sollicitées pour assurer la formation en radioprotection du personnel des entreprises appelé à intervenir en centrale nucléaire. Depuis plus de 3 ans, près de 5 000 personnes ont suivi ces cycles de formation. Le présent exposé tente donc de retracer cette démarche, dresse un premier bilan de cette action et livre quelques réflexions

The rearing of calves, kids and lambs with adults in dairy systems in the AuRA region, France

Session 45. Transformation of livestock practices in response to society’s expectationson animal welfare, market demand for animal products and environmental issuesInternational audienc

New micellar morphologies from amphiphilic block copolymers: disks, toroids and bicontinuous micelles

Amphiphilic AB and ABA block copolymers have been demonstrated to form a variety of self-assembled aggregate structures in dilute solutions where the solvent preferentially solvates one of the blocks. The most common structures formed by these amphiphilic macromolecules are spherical micelles, cylindrical micelles and vesicles (polymersomes). Interest into the characterisation and controlled formation of block copolymer aggregates has been spurred on by their potential as surfactants, nano- to micro-sized carriers for active compounds, for the controlled release of encapsulated compounds and for inorganic materials templating, amongst numerous other proposed applications. Research in the past decade has focussed not only on manipulating the properties of aggregates through control of both the chemistry of the constituent polymer blocks but also the external and internal morphology of the aggregates. This review article will present an overview of recent approaches to controlling the self-assembly of amphiphilic block copolymers with a view to obtaining novel micellar morphologies. Whilst the article touches upon multi-compartment micelles particular focus is placed upon control of the overall shape of micelles; i.e. those systems that expand the range of accessible morphologies beyond ‘simple’ spherical and cylindrical micelles namely disk-like, toroidal and bicontinuous micelles

Well-Defined Nanoparticles Formed by Hydrophobic Assembly of a Short and Polydisperse Random Terpolymer, Amphipol A8-35

International audienc

Noncanonical Self-Assembly of Highly Asymmetric Genetically Encoded Polypeptide Amphiphiles into Cylindrical Micelles

Elastin-like polypeptides (ELPs) are a class of biopolymers consisting of the pentameric repeat (VPGαG)n based on the sequence of mammalian tropoelastin that display a thermally induced soluble-to-insoluble phase transition in aqueous solution. We have discovered a remarkably simple approach to driving the spontaneous self-assembly of high molecular weight ELPs into nanostructures by genetically fusing a short 1.5 kDa (XGy)z assembly domain to one end of the ELP. Classical theories of self-assembly based on the geometric mass balance of hydrophilic and hydrophobic block copolymers suggest that these highly asymmetric polypeptides should form spherical micelles. Surprisingly, when sufficiently hydrophobic amino acids (X) are presented in a periodic sequence such as (FGG)8 or (YG)8, these highly asymmetric polypeptides self-assemble into cylindrical micelles whose length can be tuned by the sequence of the morphogenic tag. These nanostructures were characterized by light scattering, tunable resistive pulse sensing, fluorescence spectrophotometry, and thermal turbidimetry, as well as by cryogenic transmission electron microscopy (cryo-TEM) and small-angle neutron scattering (SANS). These short assembly domains provide a facile strategy to control the size, shape, and stability of stimuli responsive polypeptide nanostructures