Strange hadron matter and SU(3) symmetry

We calculate saturation curves for strange hadron matter using recently constructed baryon-baryon potentials which are constrained by SU(3) symmetry. All possible interaction channels within the baryon octet (consisting of $N$, $\Lambda$, $\Sigma$, and $\Xi$) are considered. It is found that a small $\Lambda$ fraction in nuclear matter slightly increases binding, but that larger fractions ($>10$) rapidly cause a decrease. Charge-neutral ${N,\Lambda,\Xi}$ systems, with equal densities for nucleons and cascades, are only very weakly bound. The dependence of the binding energies on the strangeness per baryon, $f_s$, is predicted for various ${N,\Lambda,\Xi}$ and ${N,\Lambda,\Sigma,\Xi}$ systems. The implications of our results in relativistic heavy-ion collisions and the core of a dense star are discussed. We also discuss the differences between our results and previous hadron matter calculations.Comment: 14 pages RevTeX, 7 postscript figure

Warm stellar matter with deconfinement: application to compact stars

We investigate the properties of mixed stars formed by hadronic and quark matter in $\beta$-equilibrium described by appropriate equations of state (EOS) in the framework of relativistic mean-field theory. We use the non- linear Walecka model for the hadron matter and the MIT Bag and the Nambu-Jona-Lasinio models for the quark matter. The phase transition to a deconfined quark phase is investigated. In particular, we study the dependence of the onset of a mixed phase and a pure quark phase on the hyperon couplings, quark model and properties of the hadronic model. We calculate the strangeness fraction with baryonic density for the different EOS. With the NJL model the strangeness content in the mixed phase decreases. The calculations were performed for T=0 and for finite temperatures in order to describe neutron and proto-neutron stars. The star properties are discussed. Both the Bag model and the NJL model predict a mixed phase in the interior of the star. Maximum allowed masses for proto-neutron stars are larger for the NJL model ($\sim 1.9$ M$_{\bigodot}$) than for the Bag model ($\sim 1.6$ M$_{\bigodot}$).Comment: RevTeX,14 figures, accepted to publication in Physical Review

Asymmetric nuclear matter:the role of the isovector scalar channel

We try to single out some qualitative new effects of the coupling to the $\delta$-isovector-scalar meson introduced in a minimal way in a phenomenological hadronic field theory. Results for the equation of state ($EOS$) and the phase diagram of asymmetric nuclear matter ($ANM$) are discussed. We stress the consistency of the $\delta$-coupling introduction in a relativistic approach. New contributions to the slope and curvature of the symmetry energy and the neutron-proton effective mass splitting appear particularly interesting. A more repulsive $EOS$ for neutron matter at high baryon densities is expected. Effects on new critical properties of warm $ANM$, mixing of mechanical and chemical instabilities and isospin distillation, are also presented. The $\delta$ influence is mostly on the {\it isovectorlike} collective response. The results are largely analytical and this makes the physical meaning quite transparent. Implications for nuclear structure properties of drip-line nuclei and for reaction dynamics with Radioactive Beams are finally pointed out.Comment: 12 pages, 10 Postscript figure

Soft-core baryon-baryon potentials for the complete baryon octet

SU(3) symmetry relations on the recently constructed hyperon-nucleon potentials are used to develop potential models for all possible baryon-baryon interaction channels. The main focus is on the interaction channels with total strangeness S=-2, -3, and -4, for which no experimental data exist yet. The potential models for these channels are based on SU(3) extensions of potential models for the S=0 and S=-1 sectors, which are fitted to experimental data. Although the SU(3) symmetry is not taken to be exact, the S=0 and S=-1 sectors still provide the necessary constraints to fix all free parameters. The potentials for the S=-2, -3, and -4 sectors, therefore, do not contain any additional free parameters, which makes them the first models of this kind. Various properties of the potentials are illustrated by giving results for scattering lengths, bound states, and total cross sections.Comment: 22 pages RevTex, 6 postscript figure

Neutron star properties in the quark-meson coupling model

The effects of internal quark structure of baryons on the composition and structure of neutron star matter with hyperons are investigated in the quark-meson coupling (QMC) model. The QMC model is based on mean-field description of nonoverlapping spherical bags bound by self-consistent exchange of scalar and vector mesons. The predictions of this model are compared with quantum hadrodynamic (QHD) model calibrated to reproduce identical nuclear matter saturation properties. By employing a density dependent bag constant through direct coupling to the scalar field, the QMC model is found to exhibit identical properties as QHD near saturation density. Furthermore, this modified QMC model provides well-behaved and continuous solutions at high densities relevant to the core of neutron stars. Two additional strange mesons are introduced which couple only to the strange quark in the QMC model and to the hyperons in the QHD model. The constitution and structure of stars with hyperons in the QMC and QHD models reveal interesting differences. This suggests the importance of quark structure effects in the baryons at high densities.Comment: 28 pages, 10 figures, to appear in Physical Review

Fatigue response evaluation of stainless steel SS 304 L(N) and SS 316 L(N) through cyclic ball indentation studies

This paper presents the results of an experimental investigation of fatigue response of stainless steel SS 304 L(N) and SS 316 L(N) using cyclic ball indentation test method. A Tungsten Carbide (WC) spherical ball of 1.57 mm diameter is used for applying compression-compression fatigue cycling on the test specimen having a nominal thickness of 5 mm; the displacement response is monitored as a function of every cycle of loading. The study focused on cases where the stainless steel specimens were welded by two different welding processes – Activated flux TIG welding and conventional multi-pass TIG welding. Fatigue response was monitored at locations of weld zone, heat affected zone (HAZ) and base metal to identify the effect of microstructure variation on fatigue response. It is observed that there is a steady increase in depth of penetration of the spherical indenter due to fatigue cycling; however, after a number of cycles, there is a sudden increase in depth of penetration which indicates the failure of the material beneath the indenter. The specimens after cyclic ball indentation were examined using a scanning electron microscope and one could observe the presence of secondary cracking in the penetrated region of the specimen

Small, Dense Quark Stars from Perturbative QCD

As a model for nonideal behavior in the equation of state of QCD at high density, we consider cold quark matter in perturbation theory. To second order in the strong coupling constant, $\alpha_s$, the results depend sensitively on the choice of the renormalization mass scale. Certain choices of this scale correspond to a strongly first order chiral transition, and generate quark stars with maximum masses and radii approximately half that of ordinary neutron stars. At the center of these stars, quarks are essentially massless.Comment: ReVTeX, 5 pages, 3 figure

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Targeted therapies and the consequent adoption of "personalized" oncology have achieved notablesuccesses in some cancers; however, significant problems remain with this approach. Many targetedtherapies are highly toxic, costs are extremely high, and most patients experience relapse after a fewdisease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistantimmortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are notreliant upon the same mechanisms as those which have been targeted). To address these limitations, aninternational task force of 180 scientists was assembled to explore the concept of a low-toxicity "broad-spectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspectsof relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a widerange of high-priority targets (74 in total) that could be modified to improve patient outcomes. For thesetargets, corresponding low-toxicity therapeutic approaches were then suggested, many of which werephytochemicals. Proposed actions on each target and all of the approaches were further reviewed forknown effects on other hallmark areas and the tumor microenvironment. Potential contrary or procar-cinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixedevidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of therelationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. Thisnovel approach has potential to be relatively inexpensive, it should help us address stages and types ofcancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for futureresearch is offered

On the mechanisms governing gas penetration into a tokamak plasma during a massive gas injection

A new 1D radial fluid code, IMAGINE, is used to simulate the penetration of gas into a tokamak plasma during a massive gas injection (MGI). The main result is that the gas is in general strongly braked as it reaches the plasma, due to mechanisms related to charge exchange and (to a smaller extent) recombination. As a result, only a fraction of the gas penetrates into the plasma. Also, a shock wave is created in the gas which propagates away from the plasma, braking and compressing the incoming gas. Simulation results are quantitatively consistent, at least in terms of orders of magnitude, with experimental data for a D 2 MGI into a JET Ohmic plasma. Simulations of MGI into the background plasma surrounding a runaway electron beam show that if the background electron density is too high, the gas may not penetrate, suggesting a possible explanation for the recent results of Reux et al in JET (2015 Nucl. Fusion 55 093013)

Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2

Selective and controlled expansion of endogenous β-cells has been pursued as a potential therapy for diabetes. Ideally, such therapies would preserve feedback control of β-cell proliferation to avoid excessive β-cell expansion and an increased risk of hypoglycemia. Here, we identified a regulator of β-cell proliferation whose inactivation results in controlled β-cell expansion: the protein deacetylase Sirtuin 2 (SIRT2). Sirt2 deletion in β-cells of mice increased β-cell proliferation during hyperglycemia with little effect in homeostatic conditions, indicating preservation of feedback control of β-cell mass. SIRT2 restrains proliferation of human islet β-cells cultured in glucose concentrations above the glycemic set point, demonstrating conserved SIRT2 function. Analysis of acetylated proteins in islets treated with a SIRT2 inhibitor revealed that SIRT2 deacetylates enzymes involved in oxidative phosphorylation, dampening the adaptive increase in oxygen consumption during hyperglycemia. At the transcriptomic level, Sirt2 inactivation has context-dependent effects on β-cells, with Sirt2 controlling how β-cells interpret hyperglycemia as a stress. Finally, we provide proof-of-principle that systemic administration of a GLP1-coupled Sirt2-targeting antisense oligonucleotide achieves β-cell selective Sirt2 inactivation and stimulates β-cell proliferation under hyperglycemic conditions. Overall, these studies identify a therapeutic strategy for increasing β-cell mass in diabetes without circumventing feedback control of β-cell proliferation