Prevention of acute kidney injury and protection of renal function in the intensive care unit : update 2017

Background: Acute kidney injury (AKI) in the intensive care unit is associated with significant mortality and morbidity. Objectives: To determine and update previous recommendations for the prevention of AKI, specifically the role of fluids, diuretics, inotropes, vasopressors/vasodilators, hormonal and nutritional interventions, sedatives, statins, remote ischaemic preconditioning and care bundles. Method: A systematic search of the literature was performed for studies published between 1966 and March 2017 using these potential protective strategies in adult patients at risk of AKI. The following clinical conditions were considered: major surgery, critical illness, sepsis, shock, exposure to potentially nephrotoxic drugs and radiocontrast. Clinical endpoints included incidence or grade of AKI, the need for renal replacement therapy and mortality. Studies were graded according to the international GRADE system. Results: We formulated 12 recommendations, 13 suggestions and seven best practice statements. The few strong recommendations with high-level evidence are mostly against the intervention in question (starches, low-dose dopamine, statins in cardiac surgery). Strong recommendations with lower-level evidence include controlled fluid resuscitation with crystalloids, avoiding fluid overload, titration of norepinephrine to a target MAP of 65-70 mmHg (unless chronic hypertension) and not using diuretics or levosimendan for kidney protection solely. Conclusion: The results of recent randomised controlled trials have allowed the formulation of new recommendations and/or increase the strength of previous recommendations. On the other hand, in many domains the available evidence remains insufficient, resulting from the limited quality of the clinical trials and the poor reporting of kidney outcomes

Construction and implementation of asymptotic expansions for Jacobi-type orthogonal polynomials

We are interested in the asymptotic behavior of orthogonal polynomials of the generalized Jacobi type as their degree n goes to ∞. These are defined on the interval [−1, 1] with weight function: w(x)=(1−x)α(1+x)βh(x),α,β>−1 and h(x) a real, analytic and strictly positive function on [−1, 1]. This information is available in the work of Kuijlaars et al. (Adv. Math. 188, 337–398 2004), where the authors use the Riemann–Hilbert formulation and the Deift–Zhou non-linear steepest descent method. We show that computing higher-order terms can be simplified, leading to their efficient construction. The resulting asymptotic expansions in every region of the complex plane are implemented both symbolically and numerically, and the code is made publicly available. The main advantage of these expansions is that they lead to increasing accuracy for increasing degree of the polynomials, at a computational cost that is actually independent of the degree. In contrast, the typical use of the recurrence relation for orthogonal polynomials in computations leads to a cost that is at least linear in the degree. Furthermore, the expansions may be used to compute Gaussian quadrature rules in O(n) operations, rather than O(n2) based on the recurrence relation

On bulk singularities in the random normal matrix model

We extend the method of rescaled Ward identities of Ameur-Kang-Makarov to study the distribution of eigenvalues close to a bulk singularity, i.e. a point in the interior of the droplet where the density of the classical equilibrium measure vanishes. We prove results to the effect that a certain "dominant part" of the Taylor expansion determines the microscopic properties near a bulk singularity. A description of the distribution is given in terms of a special entire function, which depends on the nature of the singularity (a Mittag-Leffler function in the case of a rotationally symmetric singularity).Comment: This version clarifies on the proof of Theorem

Historic buildings and the creation of experiencescapes: looking to the past for future success

Purpose: The purpose of this paper is to identify the role that the creative re-use of historic buildings can play in the future development of the experiences economy. The aesthetic attributes and the imbued historic connotation associated with the building help create unique and extraordinary “experiencescapes” within the contemporary tourism and hospitality industries. Design/methodology/approach: This paper provides a conceptual insight into the creative re-use of historic buildings in the tourism and hospitality sectors, the work draws on two examples of re-use in the UK. Findings: This work demonstrates how the creative re-use of historic buildings can help create experiences that are differentiated from the mainstream hospitality experiences. It also identifies that it adds an addition unquantifiable element that enables the shift to take place from servicescape to experiencescape. Originality/value: There has been an ongoing debate as to the significance of heritage in hospitality and tourism. However, this paper provides an insight into how the practical re-use of buildings can help companies both benefit from and contribute to the experiences economy

Random Matrix Theory for the Hermitian Wilson Dirac Operator and the chGUE-GUE Transition

We introduce a random two-matrix model interpolating between a chiral Hermitian (2n+nu)x(2n+nu) matrix and a second Hermitian matrix without symmetries. These are taken from the chiral Gaussian Unitary Ensemble (chGUE) and Gaussian Unitary Ensemble (GUE), respectively. In the microscopic large-n limit in the vicinity of the chGUE (which we denote by weakly non-chiral limit) this theory is in one to one correspondence to the partition function of Wilson chiral perturbation theory in the epsilon regime, such as the related two matrix-model previously introduced in refs. [20,21]. For a generic number of flavours and rectangular block matrices in the chGUE part we derive an eigenvalue representation for the partition function displaying a Pfaffian structure. In the quenched case with nu=0,1 we derive all spectral correlations functions in our model for finite-n, given in terms of skew-orthogonal polynomials. The latter are expressed as Gaussian integrals over standard Laguerre polynomials. In the weakly non-chiral microscopic limit this yields all corresponding quenched eigenvalue correlation functions of the Hermitian Wilson operator.Comment: 27 pages, 4 figures; v2 typos corrected, published versio

Comparative Digestibility and Nitrogen Balance of Maize Bran, Wheat Offal and Rice Bran in West African Dwarf Goats

Nine bucks West African Dwarf goats (WADg) of 8-10 months with average initial weight of 8.5±0.05 were allotted to individual metabolic cages in a CRD in a 21-days experiment to compare the digestibility and nitrogen balance of maize bran (MB), rice bran(RB) and wheat offal (WO) in WADg. Results shows that DM value ranged between 83.20% MB and 90.30% in RB while WO had the highest 11.43% of CP, ADF value ranged between 58.00% in WO to 63.00% in MB. CP intake was significantly (p<0.05) higher in goat placed on WO than other animals.. The value of CF, ADF, NDF and Ash intake was significantly similar (p>0.05) in goat fed WO and RB. The DM digestibility were significantly (p<0.05) higher (56.00%) in goats fed WO followed by RB and MB with 42.08% and 40.57% respectively. The apparent digestibility of CP were similar (p>0.05) in all the animals, CF digestibility were lower (10.80%) in animals fed WO. Acid detergent fibre (ADF) and NDF digestibility were significantly (p<0.05) higher (88.52%) and 58.33% in animal fed with RB. Nitrogen intake varied significantly (p<0.05) across the treatments with 1.96g/day in goat fed MB followed by 2.66g/day MB and 3.84g/day in animal fed WO. Animals fed WO and RB had highest significantly (p<0.05) 2.16g/day and 2.20g/day of N-balance. The positive N-balance observed in all goats suggested that N absorbed was well tolerated and utilized by the animals, so the treatments gives a better chance for dry season feed or when animals are tethered without any adverse effects

A survey on touch dynamics authentication in mobile devices

© 2016 Elsevier Ltd. All rights reserved. There have been research activities in the area of keystroke dynamics biometrics on physical keyboards (desktop computers or conventional mobile phones) undertaken in the past three decades. However, in terms of touch dynamics biometrics on virtual keyboards (modern touchscreen mobile devices), there has been little published work. Particularly, there is a lack of an extensive survey and evaluation of the methodologies adopted in the area. Owing to the widespread use of touchscreen mobile devices, it is necessary for us to examine the techniques and their effectiveness in the domain of touch dynamics biometrics. The aim of this paper is to provide some insights and comparative analysis of the current state of the art in the topic area, including data acquisition protocols, feature data representations, decision making techniques, as well as experimental settings and evaluations. With such a survey, we can gain a better understanding of the current state of the art, thus identifying challenging issues and knowledge gaps for further research

Synthesis and interaction of terminal unsaturated chemical probes with Mycobacterium tuberculosis CYP124A1

A series of C15–C20 isoprenyl derivatives bearing terminal alkenyl and alkynyl groups were synthesized as possible substrates of the methyl-branched lipid ω-hydroxylase CYP124A1 from Mycobacterium tuberculosis. The interactions of each compound with the enzyme active site were characterized using UV–vis spectroscopy. We found that C10 and C15 analogs bind with similar affinity to the corresponding parent C10 and C15 substrates geraniol and farnesol, respectively. Three analogs (C10-ω-ene, C10-ω-yne, C15-ω-yne) interact with the proximal side of the heme iron by coordinating to the oxygen atom of the ferric heme, as judged by the appearance of typical Type-IA binding spectra. On the other hand, the C15-ω-ene analog interacts with the ferric heme by displacing the bound water that generates a typical Type I binding spectrum. We were unable to detect P450-mediated oxidation of these probes following extended incubations with CYP124A1 in our reconstituted assay system, whereas a control reaction containing farnesol was converted to ω-hydroxy farnesol under the same conditions. To understand the lack of detectable oxidation, we explored the possibility that the analogs were acting as mechanism-based inhibitors, but we were unable to detect time-dependent loss of enzymatic activity. In order to gain insight into the lack of detectable turnover or time-dependent inhibition, we examined the interaction of each compound with the CYP124A1 active site using molecular docking simulations. The docking studies revealed a binding mode where the terminal unsaturated functional groups were sequestered within the methyl-binding pocket, rather than positioned close to the heme iron for oxidation. These results aid in the design of specific inhibitors of Mtb-CYP124A1, an interesting enzyme that is implicated in the oxidation of methyl-branched lipids, including cholesterol, within a deadly human pathogen

Photoelectrochemical Detection of Calcium Ions Based on Hematite Nanorod Sensors

[Image: see text] α-Fe(2)O(3) (hematite) thin films have been shown to be a robust sensor substrate for photoelectrochemical imaging with good stability and high spatial resolution. Herein, one-dimensional (1D) hematite nanorods (NRs) synthesized via a simple hydrothermal method are proposed as a substrate which provides nanostructured surfaces with enhanced photocurrent responses compared to previously described hematite films, good stability, and excellent spatial resolution for potential imaging applications. The photoelectrochemical sensing capability of hematite NRs was demonstrated by a high pH sensitivity without modification. The modification of the hematite NRs with a thin poly(vinyl chloride) (PVC)-based ion-selective film allowed highly reversible amperometric detection of calcium ions with sensor materials traditionally employed in potentiometric devices