ANALYSIS OF MORPHOLOGICAL PARAMETERS OF DENTAL SYSTEM WITH GNATHIC FORM OF MALOCCLUSION CLASS III USING SIMPLYCEPH SOFTWARE (RUSSIA)

Mesiocclusion associated with asymmetric mandibular development is a gnathic form of mesiocclusion characterized by asymmetric deformation of the facial skeleton, requiring detailed examination to perform differential diagnostics. We need to analyze lateral teleroentgenogram of the head using «SimplyCeph» software, frontal teleroentgenogram of the head, multidetector computed tomography. According to scientific data, asymmetric mandibular development is much rarer in clinical practice. Etiology of this abnormality is not determined to date. It is believed that growth zones are activated in condyloid process and mandibular angle for unknown reasons. Aim - to determine the morphological condition of stomatognathic system on the stages of rehabilitation after complex treatment of patients with asymmetric growth of mandible. Materials and methods. We examined 40 patients with malocclusion class III aged from 16 to 40. The examined group included patients with malocclusion class III that corresponded to the certain degree of severity of the abnormality: Grade I - joining of the first permanent molars and canines for Class II Angle, displacement value does not exceed 1/2 of the first permanent molar cusp. Sagittal overjet is absent; the value of anterior crossbite is minimal, moderate or deep. Results. During the stages of rehabilitation of patients with malocclusion class III and asymmetry of the mandible it is necessary to conduct a comprehensive study of facial and gnathic areas of dental system, analyze the results of radiodiagnosis of sagittal, transversal and vertical skull parameters. Conclusion. Method of subcondylar vertical osteotomy helps to normalize the morphological state of dental system. Keywords: malocclusion class III, computer program «SimplyCeph», analysis of lateral teleroentgenogram

A new era for understanding amyloid structures and disease

The aggregation of proteins into amyloid fibrils and their deposition into plaques and intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition of amyloid fibrils, collectively known as amyloidosis, is associated with many pathological conditions that can be associated with ageing, such as Alzheimer disease, Parkinson disease, type II diabetes and dialysis-related amyloidosis. However, elucidation of the atomic structure of amyloid fibrils formed from their intact protein precursors and how fibril formation relates to disease has remained elusive. Recent advances in structural biology techniques, including cryo-electron microscopy and solid-state NMR spectroscopy, have finally broken this impasse. The first near-atomic-resolution structures of amyloid fibrils formed in vitro, seeded from plaque material and analysed directly ex vivo are now available. The results reveal cross-β structures that are far more intricate than anticipated. Here, we describe these structures, highlighting their similarities and differences, and the basis for their toxicity. We discuss how amyloid structure may affect the ability of fibrils to spread to different sites in the cell and between organisms in a prion-like manner, along with their roles in disease. These molecular insights will aid in understanding the development and spread of amyloid diseases and are inspiring new strategies for therapeutic intervention

ANALYSIS OF MORPHOLOGICAL PARAMETERS OF DENTAL SYSTEM WITH GNATHIC FORM OF MALOCCLUSION CLASS III USING SIMPLYCEPH SOFTWARE (RUSSIA)

Mesiocclusion associated with asymmetric mandibular development is a gnathic form of mesiocclusion characterized by asymmetric deformation of the facial skeleton, requiring detailed examination to perform differential diagnostics. We need to analyze lateral teleroentgenogram of the head using «SimplyCeph» software, frontal teleroentgenogram of the head, multidetector computed tomography. According to scientific data, asymmetric mandibular development is much rarer in clinical practice. Etiology of this abnormality is not determined to date. It is believed that growth zones are activated in condyloid process and mandibular angle for unknown reasons. Aim - to determine the morphological condition of stomatognathic system on the stages of rehabilitation after complex treatment of patients with asymmetric growth of mandible. Materials and methods. We examined 40 patients with malocclusion class III aged from 16 to 40. The examined group included patients with malocclusion class III that corresponded to the certain degree of severity of the abnormality: Grade I - joining of the first permanent molars and canines for Class II Angle, displacement value does not exceed 1/2 of the first permanent molar cusp. Sagittal overjet is absent; the value of anterior crossbite is minimal, moderate or deep. Results. During the stages of rehabilitation of patients with malocclusion class III and asymmetry of the mandible it is necessary to conduct a comprehensive study of facial and gnathic areas of dental system, analyze the results of radiodiagnosis of sagittal, transversal and vertical skull parameters. Conclusion. Method of subcondylar vertical osteotomy helps to normalize the morphological state of dental system. Keywords: malocclusion class III, computer program «SimplyCeph», analysis of lateral teleroentgenogram.</jats:p

The hippocampal sharp wave–ripple in memory retrieval for immediate use and consolidation

Various cognitive functions have long been known to require the hippocampus. Recently, progress has been made in identifying the hippocampal neural activity patterns that implement these functions. One such pattern is the sharp wave-ripple (SWR), an event associated with highly synchronous neural firing in the hippocampus and modulation of neural activity in distributed brain regions. Hippocampal spiking during SWRs can represent past or potential future experience, and SWR-related interventions can alter subsequent memory performance. These findings and others suggest that SWRs support both memory consolidation and memory retrieval for processes such as decision-making. In addition, studies have identified distinct types of SWR based on representational content, behavioural state and physiological features. These various findings regarding SWRs suggest that different SWR types correspond to different cognitive functions, such as retrieval and consolidation. Here, we introduce another possibility - that a single SWR may support more than one cognitive function. Taking into account classic psychological theories and recent molecular results that suggest that retrieval and consolidation share mechanisms, we propose that the SWR mediates the retrieval of stored representations that can be utilized immediately by downstream circuits in decision-making, planning, recollection and/or imagination while simultaneously initiating memory consolidation processes