Eta meson rescattering effects in the p + 6Li --> eta + 7Be reaction near threshold

The p + 6Li --> eta + 7Be reaction has been investigated with an emphasis on the eta meson and 7Be interaction in the final state. Considering the 6Li and 7Be nuclei to be alpha-d and alpha-3He clusters respectively, the reaction is modelled to proceed via the p + d [alpha] --> 3He [\alpha] + eta reaction with the alpha remaining a spectator. The eta meson interacts with 7Be via multiple scatterings on the 3He and alpha clusters inside 7Be. The individual eta-3He and eta-alpha scatterings are evaluated using few body equations for the eta-3N and eta-4N systems with a coupled channel eta-N interaction as an input. Calculations including four low-lying states of 7Be lead to a double hump structure in the total cross section corresponding to the $L = 1 (J = (1/2)^-, (3/2)^-)$ and $L = 3 (J = (5/2)^-, (7/2)^-)$ angular momentum states. The humps arise due to the off-shell rescattering of the eta meson on the 7Be nucleus in the final state.Comment: New results and references adde

Self-consistent Green's function method for nuclei and nuclear matter

Recent results obtained by applying the method of self-consistent Green's functions to nuclei and nuclear matter are reviewed. Particular attention is given to the description of experimental data obtained from the (e,e'p) and (e,e'2N) reactions that determine one and two-nucleon removal probabilities in nuclei since the corresponding amplitudes are directly related to the imaginary parts of the single-particle and two-particle propagators. For this reason and the fact that these amplitudes can now be calculated with the inclusion of all the relevant physical processes, it is useful to explore the efficacy of the method of self-consistent Green's functions in describing these experimental data. Results for both finite nuclei and nuclear matter are discussed with particular emphasis on clarifying the role of short-range correlations in determining various experimental quantities. The important role of long-range correlations in determining the structure of low-energy correlations is also documented. For a complete understanding of nuclear phenomena it is therefore essential to include both types of physical correlations. We demonstrate that recent experimental results for these reactions combined with the reported theoretical calculations yield a very clear understanding of the properties of {\em all} protons in the nucleus. We propose that this knowledge of the properties of constituent fermions in a correlated many-body system is a unique feature of nuclear physics.Comment: 110 pages, accepted for publication on Prog. Part. Nucl. Phy

Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML

Occurrence of the BCR-ABL[superscript T315I] gatekeeper mutation is among the most pressing challenges in the therapy of chronic myeloid leukemia (CML). Several BCR-ABL inhibitors have multiple targets and pleiotropic effects that could be exploited for their synergistic potential. Testing combinations of such kinase inhibitors identified a strong synergy between danusertib and bosutinib that exclusively affected CML cells harboring BCR-ABL[superscript T315I]. To elucidate the underlying mechanisms, we applied a systems-level approach comprising phosphoproteomics, transcriptomics and chemical proteomics. Data integration revealed that both compounds targeted Mapk pathways downstream of BCR-ABL, resulting in impaired activity of c-Myc. Using pharmacological validation, we assessed that the relative contributions of danusertib and bosutinib could be mimicked individually by Mapk inhibitors and collectively by downregulation of c-Myc through Brd4 inhibition. Thus, integration of genome- and proteome-wide technologies enabled the elucidation of the mechanism by which a new drug synergy targets the dependency of BCR-ABL[superscript T315I] CML cells on c-Myc through nonobvious off targets

Problematic online behaviors among adolescents and emerging adults: associations between cyberbullying perpetration, problematic social media use, and psychosocial factors

Over the past two decades, young people's engagement in online activities has grown markedly. The aim of the present study was to examine the relationship between two specific online behaviors (i.e., cyberbullying perpetration, problematic social media use) and their relationships with social connectedness, belongingness, depression, and self-esteem among high school and university students. Data were collected from two different study groups via two questionnaires that included the Cyberbullying Offending Scale, Social Media Use Questionnaire, Social Connectedness Scale, General Belongingness Scale, Short Depression-Happiness Scale, and Single Item Self-Esteem Scale. Study 1 comprised 804 high school students (48% female; mean age 16.20 years). Study 2 comprised 760 university students (60% female; mean age 21.48 years). Results indicated that problematic social media use and cyberbullying perpetration (which was stronger among high school students) were directly associated with each other. Belongingness (directly) and social connectedness (indirectly) were both associated with cyberbullying perpetration and problematic social media use. Path analysis demonstrated that while age was a significant direct predictor of problematic social media use and cyberbullying perpetration among university students, it was not significant among high school students. In both samples, depression was a direct predictor of problematic social media use and an indirect predictor of cyberbullying perpetration. However, majority of these associations were relatively weak. The present study significantly adds to the emerging body of literature concerning the associations between problematic social media use and cyberbullying perpetration

Noninvasive optical inhibition with a red-shifted microbial rhodopsin

Optogenetic inhibition of the electrical activity of neurons enables the causal assessment of their contributions to brain functions. Red light penetrates deeper into tissue than other visible wavelengths. We present a red-shifted cruxhalorhodopsin, Jaws, derived from Haloarcula (Halobacterium) salinarum (strain Shark) and engineered to result in red light–induced photocurrents three times those of earlier silencers. Jaws exhibits robust inhibition of sensory-evoked neural activity in the cortex and results in strong light responses when used in retinas of retinitis pigmentosa model mice. We also demonstrate that Jaws can noninvasively mediate transcranial optical inhibition of neurons deep in the brains of awake mice. The noninvasive optogenetic inhibition opened up by Jaws enables a variety of important neuroscience experiments and offers a powerful general-use chloride pump for basic and applied neuroscience.McGovern Institute for Brain Research at MIT (Razin Fellowship)United States. Defense Advanced Research Projects Agency. Living Foundries Program (HR0011-12-C-0068)Harvard-MIT Joint Research Grants Program in Basic NeuroscienceHuman Frontier Science Program (Strasbourg, France)Institution of Engineering and Technology (A. F. Harvey Prize)McGovern Institute for Brain Research at MIT. Neurotechnology (MINT) ProgramNew York Stem Cell Foundation (Robertson Investigator Award)National Institutes of Health (U.S.) (New Innovator Award 1DP2OD002002)National Institute of General Medical Sciences (U.S.) (EUREKA Award 1R01NS075421)National Institutes of Health (U.S.) (Grant 1R01DA029639)National Institutes of Health (U.S.) (Grant 1RC1MH088182)National Institutes of Health (U.S.) (Grant 1R01NS067199)National Science Foundation (U.S.) (Career Award CBET 1053233)National Science Foundation (U.S.) (Grant EFRI0835878)National Science Foundation (U.S.) (Grant DMS0848804)Society for Neuroscience (Research Award for Innovation in Neuroscience)Wallace H. Coulter FoundationNational Institutes of Health (U.S.) (RO1 MH091220-01)Whitehall FoundationEsther A. & Joseph Klingenstein Fund, Inc.JPB FoundationPIIF FundingNational Institute of Mental Health (U.S.) (R01-MH102441-01)National Institutes of Health (U.S.) (DP2-OD-017366-01)Massachusetts Institute of Technology. Simons Center for the Social Brai

Electroproduction of the Λ(1520) Hyperon

The reaction e→pe′K+Λ(1520) with Λ(1520)→p′K− was studied at electron beam energies of 4.05, 4.25, and 4.46 GeV, using the CLAS detector at the Thomas Jefferson National Accelerator Facility. The cos θK+, φK+, Q2, and W dependencies of Λ(1520) electroproduction are presented for the kinematic region 0.9 \u3c Q2 \u3c 2.4 GeV2 and 1.95 \u3c W \u3c 2.65 GeV. Also, the Q2 dependence of the Λ(1520) decay angular distribution is presented for the first time. The cosθK+ angular distributions suggest t-channel diagrams dominate the production process. Fits to the Λ(1520) t-channel helicity frame decay angular distributions indicate the mz = ± ½ parentage accounts for about 60% of the total yield, which suggests this reaction has a significant contribution from t-channel processes with either K+ exchange or longitudinal coupling to an exchanged K*. The Q2 dependence of the Λ(1520) production cross section is the same as that observed for Λ(1116) photo- and electroproduction

A communal catalogue reveals Earth’s multiscale microbial diversity

Our growing awareness of the microbial world’s importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth’s microbial diversity

School Effects on the Wellbeing of Children and Adolescents

Well-being is a multidimensional construct, with psychological, physical and social components. As theoretical basis to help understand this concept and how it relates to school, we propose the Self-Determination Theory, which contends that self-determined motivation and personality integration, growth and well-being are dependent on a healthy balance of three innate psychological needs of autonomy, relatedness and competence. Thus, current indicators involve school effects on children’s well-being, in many diverse modalities which have been explored. Some are described in this chapter, mainly: the importance of peer relationships; the benefits of friendship; the effects of schools in conjunction with some forms of family influence; the school climate in terms of safety and physical ecology; the relevance of the teacher input; the school goal structure and the implementation of cooperative learning. All these parameters have an influence in promoting optimal functioning among children and increasing their well-being by meeting the above mentioned needs. The empirical support for the importance of schools indicates significant small effects, which often translate into important real-life effects as it is admitted at present. The conclusion is that schools do make a difference in children’s peer relationships and well-being

Exclusive Electroproduction of ᵠ Mesons at 4.2 GeV

We studied the exclusive reaction ep → e\u27 p\u27 ᵠ using the ᵠ →K+K- decay mode. The data were collected using a 4.2 GeV incident electron beam and the CEBAF Large Acceptance Spectrometer (CLAS) at the Thomas Jefferson National Accelerator Facility. Our experiment covers the range in Q2 from 0.7 to 2.2 GeV2and W from 2.0 to 2.6 GeV. Taken together with all previous data, we find a consistent picture of ᵠ production on the proton. Our measurement shows the expected decrease of the t slope with the vector-meson formation time c Δ t below 2 fm. At c Δ t = 0.6 fm, we measure bɸ = 2.27 ± 0.42 GeV-2. The cross section dependence on W as W0.2 ±0.1 at Q2, 1.3 GeV2 was determined by comparison with ɸ production at HERA after correcting for threshold effects. This is the same dependence as observed in photoproduction