33,189 research outputs found
GloPID-R report on Chikungunya, O\u27nyong-nyong and Mayaro virus, part I: Biological diagnostics
Early-onset progressive retinal atrophy associated with an IQCB1 variant in African black-footed cats (Felis nigripes)
The validity, reliability and minimal clinically important difference of the patient specific functional scale in snake envenomation
The struggling infectious diseases fellow: Remediation challenges and opportunities
Remediation of struggling learners is a challenge faced by all educators. In recognition of this reality, and in light of contemporary challenges facing infectious diseases (ID) fellowship program directors, the Infectious Diseases Society of America Training Program Directors\u27 Committee focused the 2018 National Fellowship Program Directors\u27 Meeting at IDWeek on Remediation of the Struggling Fellow. Small group discussions addressed 7 core topics, including feedback and evaluations, performance management and remediation, knowledge deficits, fellow well-being, efficiency and time management, teaching skills, and career development. This manuscript synthesizes those discussions around a competency-based framework to provide program directors and other educators with a roadmap for addressing common contemporary remediation challenges
Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects
A knowledge based system for linking information to support decision making in construction
This work describes the development of a project model centred on the information and knowledge generated and used by managers. It describes a knowledge-based system designed for this purpose. A knowledge acquisition exercise was undertaken to determine the tasks of project managers and the information necessary for and used by these tasks. This information was organised into a knowledge base for use by an expert system. The form of the knowledge lent itself to organisation into a link network. The structure of the knowledge-based system, which was developed, is outlined and its use described. Conclusions are drawn as to the applicability of the model and the final system. The work undertaken shows that it is feasible to benefit from the field of artificial intelligence to develop a project manager assistant computer program that utilises the benefit of information and its link
Validity and reliability of telephone administration of the patient-specific functional scale for the assessment of recovery from snakebite envenomation
OBJECTIVES: Although more than 1.8 million people survive snakebite envenomation each year, their recovery is understudied. Obtaining long-term follow-up is challenging in both high- and low-resource settings. The Patient-Specific Functional Scale (PSFS) is an easily administered, well-accepted patient-reported outcome that is validated for assessing limb recovery from snakebite envenomation. We studied whether the PSFS is valid and reliable when administered by telephone.
METHODS: This is a secondary analysis of data from a randomized clinical trial. We analyzed the results of PSFS collected in-person on days 3, 7, 14, 21, and 28 and by telephone on days 10, 17, and 24. We assessed the following scale psychometric properties: (a) content validity (ceiling and floor effects), (b) internal structure and consistency (Cronbach\u27s alpha), and (c) temporal and external validity using Intraclass Correlation Coefficient (ICC). Temporal stability was assessed using Spearman\u27s correlation coefficient and agreement between adjacent in-person and telephonic assessments with Cohen\u27s kappa. Bland Altman analysis was used to assess differential bias in low and high score results.
RESULTS: Data from 74 patients were available for analysis. Floor effects were seen in the early post-injury time points (median: 3 (IQR: 0, 5) at 3 days post-enrollment) and ceiling effects in the late time points (median: 9 (IQR: 8, 10). Internal consistency was good to excellent with both in-person (Cronbach α: 0.91 (95%CI 0.88, 0.95)) and telephone administration (0.81 (0.73, 0.89). Temporal stability was also good (ICC: 0.83 (0.72, 0.89) in-person, 0.80 (0.68, 0.88) telephone). A strong linear correlation was found between in-person and telephone administration (Spearman\u27s ρ: 0.83 (CI: 0.78, 0.84), consistency was assessed as excellent (Cohen\u27s κ 0.81 (CI: 0.78, 0.84), and Bland Altman analysis showed no systematic bias.
CONCLUSIONS: Telephone administration of the PSFS provides valid, reliable, and consistent data for the assessment of recovery from snakebite envenomation
Wintering Birds in Northern Saudi Arabia: February 2009
The northern plains of Saudi Arabia are an area of approximately 231,000 km2, or roughly equivalent to the size of the whole of the United Kingdom. During previous ABBA Surveys in this area in late winter and spring significant numbers of wintering species such as Dotterel Charadrius morinellus, sandgrouse Pterocles sps and eagles and vultures have been recorded, as well as the threatened Sociable Plover Vanellus gregarius. The main objective of ABBA Survey 40 (30 January - 28 February 2009) was to assess wintering populations of these birds in northern Arabia through sampling methods. In all 21 timed walked censuses in the early morning and 25 driven transect counts (over a total distance of 1511 km) were carried out. Unfortunately most of the region had suffered a severe drought over an extended period, perhaps the previous ten years or longer, and in most of the survey area there had been no rain at all during the winter/spring period of 2008/2009. This lack of rain had resulted in a complete lack of green vegetation in most of the western part of the area studied. Consequently the census results showed low species diversity and small populations
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