Town of Strafford NROC Projects

The three Strafford committees formed through the work with the Natural Resources Outreach Coalition in 2004 and supported by the grant award from the New Hampshire Estuaries Project have succeeded in furthering land protection, water quality protection, and managing growth here in Strafford. The original NROC meetings brought many new volunteer citizens into the process, but even their enthusiasm and willingness to work could not have earned these results without the financial support of the NHEP grant award. Hours of letter writing and personal contact with landowners by the volunteers of the Land Protection Group have raised awareness of the need for land protection and the ways it can be accomplished. The previous experience of the Strafford Conservation Commission in working with a landowner who was donating an easement showed us that the legal and logistical work involved is daunting. The NHEP grant allowed the land Protection Group to contract the professional services of Dan Kern of Bear-Paw Regional Greenways. His work streamlined the process for the landowners, and the Land Protection Group was able to celebrate the closing of two donated easements in 2006. Several other landowners have begun the process to protect their lands, and the Land Protection Group will continue its volunteer work. The Water Quality Group was pleased to have more than a dozen volunteers willing to focus on the need for tributary monitoring as a way to gauge and protect Bow Lake’s water quality. Testing supplies from the grant funds were essential. The sample gathering carried out at two-week intervals took place at a critical time for Bow Lake studies. Both Strafford and Northwood were in a period of legal moratorium on new development, and tributary monitoring at this time provides unique baseline data. It was not only useful in the establishment of Strafford’s Wetlands Overlay District ordinance, but will be used in future Bow Lake studies. After the Managed Growth Committee spent its time discovering gaps between the goals of the 2002 Strafford Master Plan and the present Strafford ordinances, Strafford Regional Planning Commission members helped with research for ordinances that had worked in other towns. The grant funds allowed the Committee to keep the public involved in the process and aware of the slate of proposed new ordinances that were coming up on the 2006 ballot. The blanket mailing to every Strafford address and the public meeting that followed are largely responsible for the successful passage of three new growth control ordinances. The Committee continued its work and has new measures to present to the town in 2007. The impetus and organization from NROC, and the financial support from NHEP have been a great gift to the Town of Strafford. Our thanks will be evident in the continued work and progress we make in protecting our land and water and the very nature of our town

Incentives, Information, and Emergent Collective Accuracy

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/93557/1/mde2560.pd

Holographic Multiverse

We explore the idea that the dynamics of the inflationary multiverse is encoded in its future boundary, where it is described by a lower dimensional theory which is conformally invariant in the UV. We propose that a measure for the multiverse, which is needed in order to extract quantitative probabilistic predictions, can be derived in terms of the boundary theory by imposing a UV cutoff. In the inflationary bulk, this is closely related (though not identical) to the so-called scale factor cutoff measure.Comment: 23 pages, 4 figures. Replaced to match published versio

Observers in an accelerated universe

If the current acceleration of our Universe is due to a cosmological constant, then a Coleman-De Luccia bubble will nucleate in our Universe. In this work, we consider that our observations could be likely in this framework, consisting in two infinite spaces, if a foliation by constant mean curvature hypersurfaces is taken to count the events in the spacetime. Thus, we obtain and study a particular foliation, which covers the existence of most observers in our part of spacetime.Comment: revised version, accepted in EPJ

Episode-like pulse testosterone supplementation induces tumor senescence and growth arrest down-modulating androgen receptor through modulation of p-ERK1/2, pAR ser81 and CDK1 signaling: biological implications for men treated with testosterone replacement therapy

Despite the growing body of knowledge showing that testosterone (T) may not significantly affect tumor progression in hypogonadal patients treated for prostate cancer (Pca), the use of this hormone in this population still remains controversial. The effects of continuous or pulsed T stimulation were tested in vitro and in vivo on androgen-sensitive Pca cell lines in order to assess the differential biological properties of these two treatment modalities. Pulsed T treatment resulted in a greater inhibition than continuous T supplementation of tumor growth in vitro and in vivo. The effects of pulsed T treatment on tumor growth inhibition, G0/G1 cell cycle arrest, and tumor senescence was more pronounced than those obtained upon continuous T treatments. Mechanistic studies revealed that G0/G1 arrest and tumor senescence upon pulsed T treatment were associated with a marked decrease in cyclin D1, c-Myc and SKp2, CDK4 and p-Rb levels and upregulation of p27 and p-ERK1/2. Pulsed, but not continuous, T supplementation decreased the expression levels of AR, p-AR ser81 and CDK1 in both cellular models. The in vitro results were confirmed in an in vivo xenografts, providing evidence of a greater inhibitory activity of pulsed supraphysiological T supplementation than continuous treatment, both in terms of tumor volume and decreased AR, p-AR ser81 , PSA and CDK1 staining. The rapid cycling from hypogonadal to physiological or supra-physiological T intraprostatic concentrations results in cytostatic and senescence effects in preclinical models of androgen-sensitive Pca. Our preclinical evidence provides relevant new insights in the biology of Pca response to pulsed T supplementation

Nurse staffing levels revisited: a consideration of key issues in nurse staffing levels and skill mix research.

AIM: This paper revisits the published evidence relating to how nurse staffing levels impact on patient, nurse and service outcomes and considers the implications of this body of research for nurse managers in their quest to determine optimum nursing numbers. BACKGROUND: Within the context of the recognized global nursing shortage and particular local pressures within international health services, questions of appropriate nurse staffing levels and skill mix are once again becoming increasingly important. It would seem that the determination of optimum nurse staffing levels and skill mix is a central issue in relation to health service governance, service user involvement, as well as in the recruitment, retention and well-being of nursing staff across the service sectors. METHODS: A review of published evidence was carried out, applying key principles of the systematic method, in order to facilitate the identification of current factors and issues in nurse staffing levels research. The review did not seek to address a specific research question. The search covered 10 years from 1998 to 2008 and identified more than 500 relevant papers, giving a wide international perspective. KEY ISSUES: The majority of research in the field relates to the acute service sector and there are considerable similarities in issues that transcend international boundaries. Much of the research focuses on the impact on patients and nurses of 'poor' nurse staffing levels. More recent studies have explored the impact of nurse staffing levels on the service organization itself. However, while there may be an association between models of nurse staffing and outcomes, there is insufficient evidence to establish a causal relationship between these factors. In this context it is perhaps time to reconsider how nursing outcomes are defined and measured. IMPLICATIONS FOR NURSING MANAGEMENT AND CONCLUSION: Nurse managers, commissioners of services and workforce planners need to be cognisant of key issues and analyses in the consideration of nurse staffing levels. Not least of these is the need for a healthy degree of caution regarding the supposed objectivity, scientific basis, or evidence base, for rational calculation of optimum nurse staffing levels

Equilibrium configurations of two charged masses in General Relativity

An asymptotically flat static solution of Einstein-Maxwell equations which describes the field of two non-extreme Reissner - Nordstr\"om sources in equilibrium is presented. It is expressed in terms of physical parameters of the sources (their masses, charges and separating distance). Very simple analytical forms were found for the solution as well as for the equilibrium condition which guarantees the absence of any struts on the symmetry axis. This condition shows that the equilibrium is not possible for two black holes or for two naked singularities. However, in the case when one of the sources is a black hole and another one is a naked singularity, the equilibrium is possible at some distance separating the sources. It is interesting that for appropriately chosen parameters even a Schwarzschild black hole together with a naked singularity can be "suspended" freely in the superposition of their fields.Comment: 4 pages; accepted for publication in Phys. Rev.

The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease

The dramatic recent rise in the incidence of allergic or autoimmune inflammatory diseases in the West has been proposed to reflect the lack of appropriate priming of the immune response by infectious agents such as parasitic worms during childhood. Consistent with this, there is increasing evidence supporting an inverse relationship between worm infection and T helper type 1/17 (Th1/17)-based inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes and multiple sclerosis. Perhaps more surprisingly, given that such worms often induce strong Th2-type immune responses, there also appears to be an inverse correlation between parasite load and atopy. These findings therefore suggest that the co-evolution of helminths with hosts, which has resulted in the ability of worms to modulate inflammatory responses to promote parasite survival, has also produced the benefit of protecting the host from pathological lesions arising from aggressive proinflammatory responses to infection or, indeed, aberrant inflammatory responses underlying autoimmune and allergic disorders. By focusing upon the properties of the filarial nematode-derived immunomodulatory molecule, ES-62, in this review we shall discuss the potential of exploiting the immunomodulatory products of parasitic worms to identify and develop novel therapeutics for inflammation