Mapping Inventors’ Networks to Trace Knowledge Flows Among EU Regions

Recent literature on technological changes has highlighted the role of knowledge recombination in innovation. Evidence suggests that the production of scientific and technological knowledge is becoming an increasingly collective phenomenon. Thus, in rapidly developing industries, it is almost inevitable to develop inter-organizational collaborations to identify new opportunities for new technologies. The aim of this chapter was to explore the innovative activities and networks in European regions (EU 27 plus Norway and Switzerland) from 1980 to 2010. Specifically, we analysed the most innovative sectors: environmental (green), biotechnology (biotech), laser and optic technology and nanotechnology (nanotech). This longitudinal study relies on European Patent Office (EPO) patents and inventors’ data by year and region, as provided by OECD-Regpat database. Our main findings emphasize the rise of co-inventions in intra-regional and inter-regional inventive networks, the concentration of innovations in central regions and peripheral regions’ reliance on external knowledge flows to compensate for their technological weaknesses

Global variation in anastomosis and end colostomy formation following left-sided colorectal resection

Background End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model. Results In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001). Conclusion Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone

The role of leading firms in explaining evolutionary paths of growth<. Italian and Turkish clusters on the move

This chapter presents an analysis of the long term development of the footwear industry in Italy and Turkey, focusing in particular on their main industrial districts/cluster: one in Italy and three in Turkey. Our research contributes to the reflection on the evolving relationship between history-dependent localization externalities and firm performances. Agglomeration benefits do exist in the various stages of the cluster life cycle. However, not all firms benefit equally from being in a cluster, and not all firms show an accelerated pattern of growth after being located in a cluster. We found that after the take-of and the clusters emergence, the dynamics of clusters is driven by the ability of some leading firms to connect the cluster (and its internal supply chains) to external markets and to global knowledge sources

Applying social network analysis in economic geography: framing some key analytic issues

D85, O31, R11,