11,005 research outputs found

    The effect of applied magnetic field on photocurrent generation in poly-3-hexylthiophene:[6,6]-phenyl C61-butyric acid methyl ester photovoltaic devices

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    This is the author’s version of a work that was accepted for publication in Journal of Physics: Condensed Matter http://dx.doi.org/10.1088/0953-8984/20/45/45220

    Power & persuasion: constructing identity in religious communications

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    According to Geertz (2002, p. 19), religion is “a system of symbols which acts to establish powerful, pervasive and long lasting moods and motivations” and provides adherents with a means for understanding the world. The qualities of religion mean that church communications acquire some power in forming the identities of members. In the case of immigrants, the church of the homeland is even more powerful in forming identity, because it not only functions as a repository of tradition, but also as a source of community and aid when acculturating to a ‘new’ land (Cadge & Ecklund, 2007; Ng, 2002; Peek, 2005; Yang, 1999; Vertovec, 2000). For members of the Greek Orthodox diaspora, the Church is presented as a way to be Greek by being Orthodox, which inevitably limits member expression of the self in relation to religious and ethnic identities. The purpose of this paper was to explore how a diasporic Greek Orthodox Church used its communications to establish and maintain relations of power and construct member identity. Accordingly, we applied Cheney’s (1983) rhetorical identification typology to bulletins emailed to the church congregation. At its core Cheney’s (1983) rhetorical identification typology is comprised of four strategies; the common ground technique, identification through antithesis, the ‘transcendent we’ and unifying symbols. In unearthing the presence of some of these strategies, we found that the communications may potentially assist this diaspora group in negotiating their religious and ethnic identities, but they are forced to do so within the confines of the meta-discourses of the church hierarchies they left behind. Therefore, it is not unexpected that the messages of the Greek Orthodox Church advocated participation in the church as a way of preserving members’ ‘Greek ness’, and it may be equally unsurprising that the rhetor disseminated these ideas forcefully and authoritatively despite having no certain knowledge of how the audience would receive and respond to such a strong tone

    Patterns of Individual Shopping Behavior

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    Much of economic theory is built on observations of aggregate, rather than individual, behavior. Here, we present novel findings on human shopping patterns at the resolution of a single purchase. Our results suggest that much of our seemingly elective activity is actually driven by simple routines. While the interleaving of shopping events creates randomness at the small scale, on the whole consumer behavior is largely predictable. We also examine income-dependent differences in how people shop, and find that wealthy individuals are more likely to bundle shopping trips. These results validate previous work on mobility from cell phone data, while describing the unpredictability of behavior at higher resolution.Comment: 4 pages, 5 figure

    Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches.

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    The hippocampal dentate gyrus (DG) is a unique brain region maintaining neural stem cells (NCSs) and neurogenesis into adulthood. We used multiphoton imaging to visualize genetically defined progenitor subpopulations in live slices across key stages of mouse DG development, testing decades old static models of DG formation with molecular identification, genetic-lineage tracing, and mutant analyses. We found novel progenitor migrations, timings, dynamic cell-cell interactions, signaling activities, and routes underlie mosaic DG formation. Intermediate progenitors (IPs, Tbr2+) pioneered migrations, supporting and guiding later emigrating NSCs (Sox9+) through multiple transient zones prior to converging at the nascent outer adult niche in a dynamic settling process, generating all prenatal and postnatal granule neurons in defined spatiotemporal order. IPs (Dll1+) extensively targeted contacts to mitotic NSCs (Notch active), revealing a substrate for cell-cell contact support during migrations, a developmental feature maintained in adults. Mouse DG formation shares conserved features of human neocortical expansion

    Brain MRI in a patient with classical galactosemia: acute event of unilateral hemispheric cerebral edema

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    Lifestyle Intervention Using an Internet-Based Curriculum with Cell Phone Reminders for Obese Chinese Teens: A Randomized Controlled Study

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    Objectives Obesity is an increasing public health problem affecting young people. The causes of obesity are multi-factorial among Chinese youth including lack of physical activity and poor eating habits. The use of an internet curriculum and cell phone reminders and texting may be an innovative means of increasing follow up and compliance with obese teens. The objectives of this study were to determine the feasibility of using an adapted internet curriculum and existing nutritional program along with cell phone follow up for obese Chinese teens. Design and Methods This was a randomized controlled study involving obese teens receiving care at a paediatric obesity clinic of a tertiary care hospital in Hong Kong. Forty-eight subjects aged 12 to 18 years were randomized into three groups. The control group received usual care visits with a physician in the obesity clinic every three months. The first intervention (IT) group received usual care visits every three months plus a 12-week internet-based curriculum with cell phone calls/texts reminders. The second intervention group received usual care visits every three months plus four nutritional counselling sessions. Results The use of the internet-based curriculum was shown to be feasible as evidenced by the high recruitment rate, internet log-in rate, compliance with completing the curriculum and responses to phone reminders. No significant differences in weight were found between IT, sLMP and control groups. Conclusion An internet-based curriculum with cell phone reminders as a supplement to usual care of obesity is feasible. Further study is required to determine whether an internet plus text intervention can be both an effective and a cost-effective adjunct to changing weight in obese youth. Trial Registration Chinese Clinical Trial Registry ChiCTR-TRC-12002624published_or_final_versio

    Divergent mathematical treatments in utility theory

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    In this paper I study how divergent mathematical treatments affect mathematical modelling, with a special focus on utility theory. In particular I examine recent work on the ranking of information states and the discounting of future utilities, in order to show how, by replacing the standard analytical treatment of the models involved with one based on the framework of Nonstandard Analysis, diametrically opposite results are obtained. In both cases, the choice between the standard and nonstandard treatment amounts to a selection of set-theoretical parameters that cannot be made on purely empirical grounds. The analysis of this phenomenon gives rise to a simple logical account of the relativity of impossibility theorems in economic theory, which concludes the paper

    Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B

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    Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels can be modulated by receptor-driven alterations of cyclic AMP-dependent protein kinase (PKA) activity. Here, we demonstrate that Kv channel activity is maintained by tonic activity of PKA. Whole-cell recording was used to assess the effect of manipulating PKA signalling on Kv and ATP-dependent K+ channels of rat mesenteric artery smooth muscle cells. Application of PKA inhibitors, KT5720 or H89, caused a significant inhibition of Kv currents. Tonic PKA-mediated activation of Kv appears maximal as application of isoprenaline (a β-adrenoceptor agonist) or dibutyryl-cAMP failed to enhance Kv currents. We also show that this modulation of Kv by PKA can be reversed by protein phosphatase 2B/calcineurin (PP2B). PKA-dependent inhibition of Kv by KT5720 can be abrogated by pre-treatment with the PP2B inhibitor cyclosporin A, or inclusion of a PP2B auto-inhibitory peptide in the pipette solution. Finally, we demonstrate that tonic PKA-mediated modulation of Kv requires intact caveolae. Pre-treatment of the cells with methyl-β-cyclodextrin to deplete cellular cholesterol, or adding caveolin-scaffolding domain peptide to the pipette solution to disrupt caveolae-dependent signalling each attenuated PKA-mediated modulation of the Kv current. These findings highlight a novel, caveolae-dependent, tonic modulatory role of PKA on Kv channels providing new insight into mechanisms and the potential for pharmacological manipulation of vascular tone
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