Pericardial calcification associated with leprosy: a rare combination

Majority of pericardial calcifications in the tropics are claimed to be of tuberculous origin. Other known causes include among other things uraemia, asbestosis, and post traumatic/post operative. We report a case of pericardial calcification not associated with constrictive pericarditis seen in a patient with established leprosy. Although a direct causal relationship cannot be established between leprosy and pericardial calcification, the well known condition of cardiac amyloid, a complication of leprosy might have contributed in the pathophysiology of the development of pericardial calcification in our patient. The inclusion of leprosy in the differential diagnosis of the aetiology of pericardial calcification in the tropics is suggested. Keywords: Pericardium, calcification, leprosy Annals of African Medicine Vol.2(2) 2003: 80-8

Mild Head Injury: Criteria for Computed Tomography Scan

Background/Objective: Mild Head Injury (MHI) is the most commontype of head trauma, and forms a majority of the injuries seen in the traumaunit (65-85%).1 This study was aimed at using previously identifiedclinical risk factors to determine which category of patients with MHIwould not need to undergo Computed Tomography (CT). This may serveas cost saving measure to patients and hospitals likewise reduce collectiveradiation dose to the population.Methodology: A retrospective study conducted at the trauma unit of ateaching hospital situated in the Cape Metropole. CT scan images of 50patients aged 14 years and above who had MHI and undergone CTexamination were retrieved from the archive. Patients’ information, clinicalhistory and resultant CT findings were collated. Clinical risk factors werecorrelated with abnormal and normal CT scan findings. Data wereanalyzed using chi-square statistic at 95% confidence interval.Results: Twenty three (46%) of the patients had abnormal CT findings,and all presented with one or more of these risk factors; severe headache(10%), skull fracture (20%), scalp injury (6%), loss of consciousness(LOC)(8%) and intoxication(2%). The results were not statisticallysignificant when compared with the normal CT scans group. Four patients(8%) with no risk factors had normal CT scans. All the patients presentingwith the clinical risk factors, of nausea and vomiting 6% (n=50), seizures4% (n=50) had normal CT scan findings.Conclusion: Certain clinical risk factors can be used to suggest theprobability of abnormal CT scan in patients with MHI. Patients with norisk factors such as patients with confusion and disorientation are morelikely to have normal CT findings and may therefore be exempted from CTexamination. Further studies with larger sample size may be helpful invalidating these findings

Broad Ligament Pregnancy: A Report of Two Cases

Broad ligament pregnancy is a rare event and diagnosis is often late in our setting. Two multiparous women in early thirties presented for routine antenatal care. Routine ultrasonography revealed midtrimester abdominal pregnancies. Broad ligament pregnancy was diagnosed in both cases at laparotomy and both had excision of pregnancy and salpingo-ophorectomy with satisfactory recovery. Ultrasonography is a useful tool in the early diagnosis of abdominal pregnancy in our environment. Routine ultrasonography in pregnancy is advocated in our setting.La grossesse de large ligament est rare, et parfois le diagnostique est tard. Deux femmes d\'environ trente ans font des soins ante natals de routine. D\'après une ultrasonographie de routine, elle a eu une grossesse abdominale de mi-trimestre. On a diagnostique une grossesse de large ligament dans les deux cas de laparotomie, et on a excisé la grossesse et elle a regagné la santé après même le salpingho-ophorectomie. L\'ultrasonographie est un moyen utile de diagnostiquer la grossesse abdominale. Nous proposons donc une ultrasonographie de routine pour les femmes enceintes Keywords: Broad ligament, pregnancy, ultrasonography Annals of African Medicine Vol. 7 (2) 2008: pp. 86-8

Feasibility trial for primary stroke prevention in children with sickle cell anemia in Nigeria (SPIN trial)

The vast majority of children with sickle cell anemia (SCA) live in Africa, where evidence-based guidelines for primary stroke prevention are lacking. In Kano, Nigeria, we conducted a feasibility trial to determine the acceptability of hydroxyurea therapy for primary stroke prevention in children with abnormal transcranial Doppler (TCD) measurements. Children with SCA and abnormal non-imaging TCD measurements (≥200 cm/s) received moderate fixed-dose hydroxyurea therapy (∼20 mg/kg/day). A comparison group of children with TCD measurements <200 cm/s was followed prospectively. Approximately 88% (330 of 375) of families agreed to be screened, while 87% (29 of 33) of those with abnormal TCD measurements, enrolled in the trial. No participant elected to withdraw from the trial. The average mean corpuscular volume increased from 85.7 fl at baseline to 95.5 fl at 24 months (not all of the children who crossed over had a 24 month visit), demonstrating adherence to hydroxyurea. The comparison group consisted of initially 210 children, of which four developed abnormal TCD measurements, and were started on hydroxyurea. None of the monthly research visits were missed (n = total 603 visits). Two and 10 deaths occurred in the treatment and comparison groups, with mortality rates of 2.69 and 1.81 per 100 patient-years, respectively (P = .67). Our results provide strong evidence, for high family recruitment, retention, and adherence rates, to undertake the first randomized controlled trial with hydroxyurea therapy for primary stroke prevention in children with SCA living in Africa

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Trauma, Preparedness, Nigeria

A 5-day-old boy who was referred from University of Benin Teaching Hospital to the University College Hospital Ibadan with features of oesophageal atresia which was confirmed by barium swallow study. He had successful surgical anastomosis of the proximal and distal oesophageal loops with resection of the tracheo-oesophageal fistula. The literature has been reviewed.Sahel Medical Journal Vol. 10 (3) 2007: pp. 130-10