Finite-difference model for one-dimensional electro-osmotic consolidation

Abstract not availableYadong Zhou, An Deng, Can Wan

Adaptation of water resources systems to changing society and environment: a statement by the International Association of Hydrological Sciences

Hydrol. Sci. J.-J. Sci. Hydrol.ISI Document Delivery No.: EB2CDTimes Cited: 0Cited Reference Count: 153Ceola, Serena Montanari, Alberto Krueger, Tobias Dyer, Fiona Kreibich, Heidi Westerberg, Ida Carr, Gemma Cudennec, Christophe Elshorbagy, Amin Savenije, Hubert Van der Zaag, Pieter Rosbjerg, Dan Aksoy, Hafzullah Viola, Francesco Petrucci, Guido MacLeod, Kit Croke, Barry Ganora, Daniele Hermans, Leon Polo, Maria J. Xu, Zongxue Borga, Marco Helmschrot, Jorg Toth, Elena Ranzi, Roberto Castellarin, Attilio Hurford, Anthony Brilly, Mitija Viglione, Alberto Bloeschl, Guenter Sivapalan, Murugesu Domeneghetti, Alessio Marinelli, Alberto Di Baldassarre, GiulianoPeople Programme (Marie Curie Actions) of the European Union [329762]; IRI THESys; German Excellence Initiative; EU [603587]IW acknowledges the support of the People Programme (Marie Curie Actions) of the European Union's 7th Framework Programme FP7/2007-2013/(grant agreement no. 329762). TK is funded, through IRI THESys, by the German Excellence Initiative. SC, AM, AC, and ET acknowledge financial support from the EU funded project SWITCHON (603587).Taylor & francis ltdAbingdonWe explore how to address the challenges of adaptation of water resources systems under changing conditions by supporting flexible, resilient and low-regret solutions, coupled with on-going monitoring and evaluation. This will require improved understanding of the linkages between biophysical and social aspects in order to better anticipate the possible future co-evolution of water systems and society. We also present a call to enhance the dialogue and foster the actions of governments, the international scientific community, research funding agencies and additional stakeholders in order to develop effective solutions to support water resources systems adaptation. Finally, we call the scientific community to a renewed and unified effort to deliver an innovative message to stakeholders. Water science is essential to resolve the water crisis, but the effectiveness of solutions depends, inter alia, on the capability of scientists to deliver a new, coherent and technical vision for the future development of water systems

Cholangiocarcinoma in Magnetic Resonance Cholangiopancreatography and Fascioliasis in Endoscopic Ultrasonography

Fascioliasis is a worldwide zoonotic infection with Fasciola hepatica and Fasciola gigantica. The zoonoses are particularly endemic in sheep-raising countries and are also endemic in Iran. Typical symptoms that may be associated with fascioliasis can be divided by phases of the disease, including the acute or liver phase, the chronic or biliary phase, and ectopic or pharyngeal fascioliasis. Cholestatic symptoms may be absent, and in some cases diagnosis and treatment may be preceded by a long period of abdominal pain, eosinophilia and vague gastrointestinal symptoms. We report a case with epigastric and upper quadrant abdominal pain for the last 4 years, with imaging suggesting cholangiocarcinoma. Considering a new concept of endoscopic ultrasonography, at last F. hepatica was extracted with endoscopic retrograde cholangiography

Origin of an Alternative Genetic Code in the Extremely Small and GC–Rich Genome of a Bacterial Symbiont

The genetic code relates nucleotide sequence to amino acid sequence and is shared across all organisms, with the rare exceptions of lineages in which one or a few codons have acquired novel assignments. Recoding of UGA from stop to tryptophan has evolved independently in certain reduced bacterial genomes, including those of the mycoplasmas and some mitochondria. Small genomes typically exhibit low guanine plus cytosine (GC) content, and this bias in base composition has been proposed to drive UGA Stop to Tryptophan (Stop→Trp) recoding. Using a combination of genome sequencing and high-throughput proteomics, we show that an α-Proteobacterial symbiont of cicadas has the unprecedented combination of an extremely small genome (144 kb), a GC–biased base composition (58.4%), and a coding reassignment of UGA Stop→Trp. Although it is not clear why this tiny genome lacks the low GC content typical of other small bacterial genomes, these observations support a role of genome reduction rather than base composition as a driver of codon reassignment

Diffusion tensor imaging with deterministic error bounds

Errors in the data and the forward operator of an inverse problem can be handily modelled using partial order in Banach lattices. We present some existing results of the theory of regularisation in this novel framework, where errors are represented as bounds by means of the appropriate partial order. We apply the theory to diffusion tensor imaging (DTI), where correct noise modelling is challenging: it involves the Rician distribution and the nonlinear Stejskal-Tanner equation. Linearisation of the latter in the statistical framework would complicate the noise model even further. We avoid this using the error bounds approach, which preserves simple error structure under monotone transformations.While at the Center for Mathematical Modelling of the Escuela Politécnica Nacional in Quito, Ecuador, T. Valkonen has been supported by a Prometeo scholarship of the Senescyt (Ecuadorian Ministry of Science, Technology, Education, and Innovation). In Cambridge, T. Valkonen has been supported by the EPSRC grants Nr. EP/J009539/1 “Sparse & Higher-order Image Restoration”, and Nr. EP/M00483X/1 “Efficient computational tools for inverse imaging problems”. A. Gorokh and Y. Korolev are grateful to the RFBR (Russian Foundation for Basic Research) for partial financial support (projects 14-01-31173 and 14-01-91151)

Evaluation of oxidative stress parameters and metabolic activities of nurses working day and night shifts

The aim of this study was to evaluate the oxidative stress and metabolic activities of nurses working day and night shifts. Intensive care unit (ICU) (n=70) and ordinary service (OS) nurses (n=70) were enrolled in the study. Just before and the end of the shifts, blood samples were obtained to measure the participants' oxidative stress parameters. Metabolic activities were analyzed using the SenseWear Armband. Oxidative stress parameters were increased at the end of the shifts for all OS and ICU nurses compared to the beginning of the shifts. Compared to the OS nurses, the ICU nurses' TAS, TOS, and OSI levels were not significantly different at the end of the day and night shifts. The metabolic activities of the OS and ICU nurses were found to be similar. As a result, the OS and ICU nurses' oxidative stress parameters and metabolic activities were not different, and all of the nurses experienced similar effects from both the day and night shifts

Designing an optimised supply network for sustainable conversion of waste agricultural plastics into higher value products

Agricultural plastics are currently characterised by a predominantly linear take-make-dispose value chain, thus being a major stream of waste that contributes to significant environmental and economic issues. Therefore, policy makers have recently indicated the adoption of circular economy approaches as the way forward for plastics. This study addresses the problem of agricultural plastic waste as a major stream of landfilled waste by assessing the potential for recycling the plastic into higher value products through pyrolysis and by optimally designing the respective supply network to support this process. A Mixed Integer Linear Programming (MILP) model is developed to optimise the end-to-end supply network design, from the waste generation stage up to the end consumer of the produced material. The model is supported by experimental results on the pyrolysis performance for contaminated plastic samples. The model is applied in a case study of the Scottish agricultural sector to showcase its potential in assessing the feasibility and financial viability in addition to the positive environmental impact on agricultural plastic waste supply networks. The results demonstrate the potential of using the pyrolysis technology for agricultural plastic waste recycling as an example of a circular economy approach and the benefits of using the developed model for decision making purposes, as well as the potential for waste reduction and the implications for farmers’ operations

Bi-allelic variants in HOPS complex subunit VPS41 cause cerebellar ataxia and abnormal membrane trafficking.

Membrane trafficking is a complex, essential process in eukaryotic cells responsible for protein transport and processing. Deficiencies in vacuolar protein sorting (VPS) proteins, key regulators of trafficking, cause abnormal intracellular segregation of macromolecules and organelles and are linked to human disease. VPS proteins function as part of complexes such as the homotypic fusion and vacuole protein sorting (HOPS) tethering complex, composed of VPS11, VPS16, VPS18, VPS33A, VPS39 and VPS41. The HOPS-specific subunit VPS41 has been reported to promote viability of dopaminergic neurons in Parkinson's disease but to date has not been linked to human disease. Here, we describe five unrelated families with nine affected individuals, all carrying homozygous variants in VPS41 that we show impact protein function. All affected individuals presented with a progressive neurodevelopmental disorder consisting of cognitive impairment, cerebellar atrophy/hypoplasia, motor dysfunction with ataxia and dystonia, and nystagmus. Zebrafish disease modelling supports the involvement of VPS41 dysfunction in the disorder, indicating lysosomal dysregulation throughout the brain and providing support for cerebellar and microglial abnormalities when vps41 was mutated. This provides the first example of human disease linked to the HOPS-specific subunit VPS41 and suggests the importance of HOPS complex activity for cerebellar function