116 research outputs found
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
- Author
- Aamir A
- Abbas J
- Abbas N
- Abbott TEF
- Abdalla M
- Abdikadir H
- Abuhussein N
- Acquaah F
- Adamson R
- Adeleye O
- Adeogun A
- Adlan A
- Aftab R
- Afzal Z
- Agarwal M
- Aglan H
- Agnew CJF
- Agrawal R
- Ahern D
- Ahluwalia J
- Ahluwalia V
- Ahmad A
- Ahmad K
- Ahmed H
- Ahmed I
- Ahmed L
- Ahmed N
- Ahmed P
- Ainger E
- Ainsworth P
- Aishwarya G
- Ajibola-Taylor O
- Akhbari M
- Akhtar A
- Akhtar R
- Akpenyi O
- Al-Ausi M
- Al-Huneidi R
- Al-Khudairi R
- Al-Masri S
- Al-Mousawi A
- Al-Saadi N
- Alagappan A
- Alberts J
- Alfa-Wali M
- Ali A
- Ali B
- Ali I
- Ali M
- Ali Q
- Ali S
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- Alwandi A
- Amani L
- Amarnath T
- Amer M
- Amin H
- Amin MN
- Amoah R
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- Ananthavarathan P
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- Andrews H
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- Ang JJ
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- Appleton S
- Aquilina T
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- Arneill M
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- Auluck I
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- Shields P
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- Siddiqui I
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- Sim DPY
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- Singagireson S
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- Sivagnanasithiyar T
- Sivakumar C
- Sivakumar R
- Skulsky S
- Slade G
- Slade RD
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- Sriram A
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- Stanier P
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators, Nepogodiev, D
- Stechman M
- Stewart D
- Stewart E
- Stewart H
- Stewart R
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- Stoddart MT
- Stokes E
- Stott G
- Strang S
- Stringer H
- Stringfellow TD
- Stubbing-Moore A
- Sturrock S
- Subar D
- Subratty SM
- Sukirthan N
- Sukumar S
- Sulaiman SK
- Sultan S
- Sun L
- Sundaram K
- Suresh R
- Suresh S
- Sureshkumar A
- Suri A
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- Swan A
- Swan I
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- Symons L
- Szczap A
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- Tam J
- Tam JP
- Tan CY
- Tan KL
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- Tan TSE
- Tang A
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- Taribagil P
- Tariq A
- Tate S
- Tayeh S
- Taylor K
- Taylor O
- Taylor R
- Taylor Z
- Telfer R
- Teng T
- Tenters F
- Teo R
- Thachettu A
- Thakrar D
- Thatcher A
- Theodoropoulou K
- Thomas A
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- Tsang JCH
- Tsang K
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- Turner J
- Turner S
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- Ubhi HK
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- Whitcroft I
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- Wynell-Mayow W
- Xu Y
- Yahaya AA
- Yalamarthi S
- Yang DD
- Yang N
- Yap J
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- Yarham E
- Yasin IH
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- Yogeswara T
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- Yousaf A
- Youssef H
- Yu T
- Yule A
- Zaat S
- Zanichelli D
- Zaver V
- Zeng R
- Zhang Y
- Zheleniakova T
- Zhu Y
- Zornoza A
- Zubikarai G
- Zulkifli A
- Zuzarte L
- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
Generic Delivery of Payload of Nanoparticles Intracellularly via Hybrid Polymer Capsules for Bioimaging Applications
- Author
- A Muñoz Javier
- AG Skirtach
- AG Skirtach
- AL Rogach
- AM Pavlov
- APR Johnston
- AS Angelatos
- Ashok Kumar
- Auhin K. Maparu
- B Städler
- BD Chithrani
- BG De Geest
- C Alric
- C Cortez
- DA Gorin
- DG Shchukin
- DG Shchukin
- F Caruso
- F Caruso
- F Yuan
- F Zhao
- FM Kievit
- G Büchel
- Haider Sami
- HY Koo
- J Cui
- K Riehemann
- K Thurn
- LL del Mercato
- M Melancon
- MF Bedard
- NR Jana
- PR Gil
- S Sivakumar
- S Sivakumar
- S Sivakumar
- S Sivakumar
- Sangaru Shiv Shankar
- Sri Sivakumar
- T Mosmann
- TK Sau
- WS Choi
- X Xu
- Y Song
- Y Wang
- Y Wang
- Publication venue
- Public Library of Science
- Publication date
- 23/05/2012
- Field of study
Towards the goal of development of a generic nanomaterial delivery system and delivery of the ‘as prepared’ nanoparticles without ‘further surface modification’ in a generic way, we have fabricated a hybrid polymer capsule as a delivery vehicle in which nanoparticles are loaded within their cavity. To this end, a generic approach to prepare nanomaterials-loaded polyelectrolyte multilayered (PEM) capsules has been reported, where polystyrene sulfonate (PSS)/polyallylamine hydrochloride (PAH) polymer capsules were employed as nano/microreactors to synthesize variety of nanomaterials (metal nanoparticles; lanthanide doped inorganic nanoparticles; gadolinium based nanoparticles, cadmium based nanoparticles; different shapes of nanoparticles; co-loading of two types of nanoparticles) in their hollow cavity. These nanoparticles-loaded capsules were employed to demonstrate generic delivery of payload of nanoparticles intracellularly (HeLa cells), without the need of individual nanoparticle surface modification. Validation of intracellular internalization of nanoparticles-loaded capsules by HeLa cells was ascertained by confocal laser scanning microscopy. The green emission from Tb3+ was observed after internalization of LaF3:Tb3+(5%) nanoparticles-loaded capsules by HeLa cells, which suggests that nanoparticles in hybrid capsules retain their functionality within the cells. In vitro cytotoxicity studies of these nanoparticles-loaded capsules showed less/no cytotoxicity in comparison to blank capsules or untreated cells, thus offering a way of evading direct contact of nanoparticles with cells because of the presence of biocompatible polymeric shell of capsules. The proposed hybrid delivery system can be potentially developed to avoid a series of biological barriers and deliver multiple cargoes (both simultaneous and individual delivery) without the need of individual cargo design/modification
Hybrid inorganic-organic capsules for efficient intracellular delivery of novel siRNAs against influenza A (H1N1) virus infection
- Author
- A Fougerolles de
- A Ott
- A Yoshimura
- A Zintchenko
- AI Petrov
- AL Becker
- AM Pavlov
- AM Pavlov
- APR Johnston
- AR Pandiri
- AS Monto
- AS Timin
- AS Timin
- AS Timin
- AS Timin
- B Rubinsky
- BV Parakhonskiy
- C Ganas
- D Vlaskou
- DV Volodkin
- E Clercq De
- EA Moreira
- GA Poland
- GB Sukhorukov
- GB Sukhorukov
- H Gao
- H Gao
- H Suzuki
- H-Y Sui
- J Conde
- J DeVincenzo
- J Peteiro-Cartelle
- J Shao
- JA Gollob
- JA Udovich
- JJ Skehel
- LL Mercato del
- M Kakran
- M-L Temmerman De
- MN Antipina
- MS Al-Dosari
- N Nafee
- P Pereira
- Q Ge
- Q Ge
- R Fouchier
- S Barik
- S Koker De
- SM Hammond
- SM Tompkins
- T Betakova
- Y Bao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 08/03/2017
- Field of study
This work was supported by ARUK project grant 21210 ‘Sustained and Controllable Local Delivery of Anti-inflammatory Therapeutics with Nanoengineered Microcapsules’. The work was also supported in part by Russian Foundation of Basic Research grants No. 16-33-50153 mol_nr, No. 16-33-00966 mol_a, Russian Science Foundation grant No. 15-15-00170 and Russian Governmental Program ‘‘Nauka’’, No. 1.1658.2016, 4002
Facile Preparation of Crosslinked Polymeric Nanocapsules via Combination of Surface-Initiated Atom Transfer Radical Polymerization and Ultraviolet Irradiated Crosslinking Techniques
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Search for new physics in events with opposite-sign leptons, jets, and missing transverse energy in pp collisions at root s=7 TeV
- Author
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- Abbiendi G
- Abbrescia M
- Abdullin S
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- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
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- Alda WL
- Alexander J
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- Alimena J
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- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
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- Andrea J
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- Bai Y
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- Chang P
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- Chertok M
- Chetluru V
- Cheung HWK
- CHHIBRA Simranjit Singh
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- Chung J
- Chung YS
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- Cifuentes JAB
- Cimmino A
- Cipriano PMR
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
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- Clarida W
- Clement E
- Clerbaux B
- Cline D
- Cockerill DJA
- Codispoti G
- Colafranceschi S
- Colaleo A
- Cole JE
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- Collaboration C
- Collard C
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- Contardo D
- Conte E
- Contreras Campana C
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- Conway J
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- Cooper SI
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- Cortabitarte RV
- Cortezon EP
- Cossutti F
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- Costa S
- Costantini S
- Costanza F
- Coughlan JA
- Cousins R
- Covarelli R
- Cox B
- Cox PT
- CREANZA Donato Maria
- Cremaldi LM
- Cripps N
- Cuevas J
- Cuffiani M
- Cumalat JP
- Cuplov V
- Cushman P
- Cussans D
- Custodio A
- Cutajar M
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- Cwiok M
- Czellar S
- D'Agnolo RT
- D'Alessandro R
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- D'Enterria D
- D'Hondt J
- Da Costa EM
- Da Silva WLP
- Dabrowski A
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- Dahmes B
- Dahms T
- Dallavalle GM
- Damgov J
- Damiao DD
- Dammann D
- Danielson T
- Das S
- Daskalakis G
- Dasu S
- Daubie E
- Dauncey P
- David A
- Davids M
- Davies G
- de Barbaro P
- De Benedetti A
- De Boer W
- de Cassagnac RG
- De Cosa A
- de Fatis TT
- DE FILIPPIS Nicola
- De Gruttola M
- De Guio F
- De La Cruz B
- De La Cruz Burelo E
- De Lentdecker G
- De Mattia M
- de Monchenault GH
- De Palma M
- De Roeck A
- De Souza SF
- de Troconiz JF
- De Visscher S
- De Wolf EA
- Deisher A
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- Dejardin M
- del Arbol PMR
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- Dermenev A
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
A search is presented for physics beyond the standard model (BSM) in final states with a pair of opposite-sign isolated leptons accompanied by jets and missing transverse energy. The search uses LHC data recorded at a center-of-mass energy root s = 7 TeV with the CMS detector, corresponding to an integrated luminosity of approximately 5 fb(-1). Two complementary search strategies are employed. The first probes models with a specific dilepton production mechanism that leads to a characteristic kinematic edge in the dilepton mass distribution. The second strategy probes models of dilepton production with heavy, colored objects that decay to final states including invisible particles, leading to very large hadronic activity and missing transverse energy. No evidence for an event yield in excess of the standard model expectations is found. Upper limits on the BSM contributions to the signal regions are deduced from the results, which are used to exclude a region of the parameter space of the constrained minimal supersymmetric extension of the standard model. Additional information related to detector efficiencies and response is provided to allow testing specific models of BSM physics not considered in this Letter. (C) 2012 CERN. Published by Elsevier B.V. All rights reserved
Search for narrow resonances in dilepton mass spectra in pp collisions at s=7TeV
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- Yilmaz Y
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- Zatserklyaniy A
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- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
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- Zhukov V
- Zhukova V
- Zielinski M
- Zito G
- Zotto P
- Zou W
- Zucchetta A
- Zuranski A
- Publication venue
- Publication date
- 02/03/2018
- Field of study
Search for a light pseudoscalar Higgs boson in the dimuon decay channel in pp collisions at √s=7TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Adair A
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- Adam W
- Adams JR
- Adams MR
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- Adler V
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- Anastassov A
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- Yi K
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- Yilmaz Y
- Yohay R
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- Zakaria M
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- Zatserklyaniy A
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- Zeyrek M
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- Zhu B
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- Publication venue
- Publication date
- 02/03/2018
- Field of study
Search for high-mass resonances decaying into τ-lepton pairs in pp collisions at √ s = 7TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Adair A
- Adam N
- Adam W
- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agram J-L
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- AlcarazMaestre J
- Aldaya Martin M
- Aldá Júnior WL
- Alexander J
- Aliev T
- Alimena J
- Almeida N
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Antonelli L
- Antunovic Z
- Apanasevich L
- Appelt E
- Apresyan A
- Arce P
- Arcidiacono R
- Arenton MW
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- Publication venue
- Publication date
- 02/03/2018
- Field of study
Measurement of the inelastic proton-proton cross section at root s=7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Acosta MV
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
A measurement is presented of the inelastic proton-proton cross section at a centre-of-mass energy of root s = 7 TeV. Using the CMS detector at the LHC, the inelastic cross section is measured through two independent methods based on information from (i) forward calorimetry (for pseudorapidity 3 200 MeV/c. The measurements cover a large fraction of the inelastic cross section for particle production over about nine units of pseudorapidity and down to small transverse momenta. The results are compared with those of other experiments, and with models used to describe high-energy hadronic interactions. (C) 2013 CERN. Published by Elsevier B.V. All rights reserved
Search for charge-asymmetric production of W ' bosons in tt+jet events from pp collisions at √s=7 TeV
- Author
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- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
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- Shipkowski SP
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- Shoaib M
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- Shreyber I
- Shukla P
- Shumeiko N
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- Siegrist P
- Sigamani M
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- Silverwood H
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- Singovsky A
- Sinthuprasith T
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- Sirunyan AM
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- Stephans GSF
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- Stober FM
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- Sánchez-Hernández A
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- Taurok A
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- Teo WD
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- Troendle D
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- Tsang KV
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- Tuovinen E
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- Vesztergombi G
- Veverka J
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- Vila I
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- Villella I
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- Zuranski A
- Publication venue
- Publication date
- 02/03/2018
- Field of study
- …
