Scientific, sustainability and regulatory challenges of cultured meat

Producing meat without the drawbacks of conventional animal agriculture would greatly contribute to future food and nutrition security. This Review Article covers biological, technological, regulatory and consumer acceptance challenges in this developing field of biotechnology. Cellular agriculture is an emerging branch of biotechnology that aims to address issues associated with the environmental impact, animal welfare and sustainability challenges of conventional animal farming for meat production. Cultured meat can be produced by applying current cell culture practices and biomanufacturing methods and utilizing mammalian cell lines and cell and gene therapy products to generate tissue or nutritional proteins for human consumption. However, significant improvements and modifications are needed for the process to be cost efficient and robust enough to be brought to production at scale for food supply. Here, we review the scientific and social challenges in transforming cultured meat into a viable commercial option, covering aspects from cell selection and medium optimization to biomaterials, tissue engineering, regulation and consumer acceptance

A mechanical structure-based design method and its implementation on a fly-cutting machine tool design

The mechanical structure has a main influence of the machining performance and the servo performance. In this study, a mechanical structure-based design method is presented to design and optimize an ultraprecision fly-cutting machine tool. This method takes full account of the influence of mechanical components on the machining performance and servo performance at the design stage. The effect of the components structure on the roughness of machined surface is discussed, and an optimized structural form of the aerostatic spindle is given. The influence of the mechanical structure on the control system and electronic drives is discussed, and an integrated dynamic design model is built and used to optimize the hydrostatic slide. Furthermore, the impact of mechanical system dynamic performance of the machine tool on the processing topography is analyzed by the finite element model of the machine tool. This method provides a theoretical basis for the design and optimization of mechanical components and machine tools stiffness loop