Experimental characterization of a 400 Gbit/s orbital angular momentum multiplexed free-space optical link over 120 m

We experimentally demonstrate and characterize the performance of a 400-Gbit/s orbital angular momentum (OAM) multiplexed free-space optical link over 120- meters on the roof of a building. Four OAM beams, each carrying a 100-Gbit/s QPSK channel are multiplexed and transmitted. We investigate the influence of channel impairments on the received power, inter-modal crosstalk among channels, and system power penalties. Without laser tracking and compensation systems, the measured received power and crosstalk among OAM channels fluctuate by 4.5 dB and 5 dB, respectively, over 180 seconds. For a beam displacement of 2 mm that corresponds to a pointing error less than 16.7 μrad, the link bit-error-rates are below the forward error correction threshold of 3.8×10-3 for all channels. Both experimental and simulation results show that power penalties increase rapidly when the displacement increases

Mode-division-multiplexing of multiple Bessel-Gaussian beams carrying orbital-angular-momentum for obstruction-tolerant free-space optical and millimetre-wave communication links

We experimentally investigate the potential of using ‘self-healing’ Bessel-Gaussian beams carrying orbital-angular-momentum to overcome limitations in obstructed free-space optical and 28-GHz millimetre-wave communication links. We multiplex and transmit two beams (l = +1 and +3) over 1.4 metres in both the optical and millimetre-wave domains. Each optical beam carried 50-Gbaud quadrature-phase-shift-keyed data, and each millimetre-wave beam carried 1-Gbaud 16-quadrature-amplitude-modulated data. In both types of links, opaque disks of different sizes are used to obstruct the beams at different transverse positions. We observe self-healing after the obstructions, and assess crosstalk and power penalty when data is transmitted. Moreover, we show that Bessel-Gaussian orbital-angular-momentum beams are more tolerant to obstructions than non-Bessel orbital-angular-momentum beams. For example, when obstructions that are 1 and 0.44 the size of the l = +1 beam, are placed at beam centre, optical and millimetre-wave Bessel-Gaussian beams show ~6 dB and ~8 dB reduction in crosstalk, respectively

Exponentially Increasing Incidences of Cutaneous Malignant Melanoma in Europe Correlate with Low Personal Annual UV Doses and Suggests 2 Major Risk Factors

For several decades the incidence of cutaneous malignant melanoma (CMM) steadily increased in fair-skinned, indoor-working people around the world. Scientists think poor tanning ability resulting in sunburns initiate CMM, but they do not understand why the incidence continues to increase despite the increased use of sunscreens and formulations offering more protection. This paradox, along with lower incidences of CMM in outdoor workers, although they have significantly higher annual UV doses than indoor workers have, perplexes scientists. We found a temporal exponential increase in the CMM incidence indicating second-order reaction kinetics revealing the existence of 2 major risk factors. From epidemiology studies, we know one major risk factor for getting CMM is poor tanning ability and we now propose the other major risk factor may be the Human Papilloma Virus (HPV) because clinicians find β HPVs in over half the biopsies. Moreover, we uncovered yet another paradox; the increasing CMM incidences significantly correlate with decreasing personal annual UV dose, a proxy for low vitamin D3 levels. We also discovered the incidence of CMM significantly increased with decreasing personal annual UV dose from 1960, when it was almost insignificant, to 2000. UV and other DNA-damaging agents can activate viruses, and UV-induced cytokines can hide HPV from immune surveillance, which may explain why CMM also occurs in anatomical locations where the sun does not shine. Thus, we propose the 2 major risk factors for getting CMM are intermittent UV exposures that result in low cutaneous levels of vitamin D3 and possibly viral infection

Engineering design of the EURISOL multi-MW spallation target

The European Isotope Separation On-Line Radioactive Ion Beam project (EURISOL) is set to design the 'next-generation' European Isotope Separation On-Line (ISOL) Radioactive Ion Beam (RIB) facility. It will extend and amplify current research on nuclear physics, nuclear astrophysics and fundamental interactions beyond the year 2010. In EURISOL, four target stations are foreseen, three direct targets of approximately 100 kW of beam power and one multi-MW target assembly, all driven by a high-power particle accelerator. In this high power target station, high-intensity RIBs of neutron-rich isotopes will be obtained by inducing fission in several actinide targets surrounding a liquid metal spallation neutron source. This article summarises the work carried out within Task 2 of the EURISOL Design Study, with special attention to the coupled neutronics of the mercury proton-to-neutron converter and the fission targets. The overall performance of the facility, which will sustain fast neutron fluxes of the order of 1014 n/cm2/s, is evaluated, together with the production of radionuclides in the actinide targets, showing that the targeted 1015 fissions/s can be achieved. Some of the greatest challenges in the design of high power spallation sources are the high power densities, entailing large structural stresses, and the heat removal, requiring detailed thermo-hydraulic calculations. The use of a thin martensitic steel beam-window and a well-controlled mercury flow has been shown to reduce the von-Misses stress in the former below the 200 MPa limit, with reasonable maximum flow rates of ~6 m/s. Alternatively, a windowless target configuration has been proposed, based on a liquid mercury transverse film. With this design, higher power densities and fission rates may be achieved, avoiding the technical difficulties related to the beam window. Experimentally, several tests have been performed at IPUL (Riga, Latvia) in order to study the stability of the liquid metal flow and validate the mercury loop design

Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line

Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates induce changes in sodium ion channel currents known to be associated with neuropathic pain. Twenty VZV isolates were studied blind from 11 PHN and 9 non-PHN subjects. Viruses were propagated in the MeWo cell line from which cell-free virus was harvested and applied to the ND7/23-Nav1.8 rat DRG x mouse neuroblastoma hybrid cell line which showed constitutive expression of the exogenous Nav 1.8, and endogenous expression of Nav 1.6 and Nav 1.7 genes all encoding sodium ion channels the dysregulation of which is associated with a range of neuropathic pain syndromes. After 72 hrs all three classes of VZV gene transcripts were detected in the absence of infectious virus. Single cell sodium ion channel recording was performed after 72 hr by voltage-clamping. PHN-associated VZV significantly increased sodium current amplitude in the cell line when compared with non-PHN VZV, wild-type (Dumas) or vaccine VZV strains ((POka, Merck and GSK). These sodium current increases were unaffected by acyclovir pre-treatment but were abolished by exposure to Tetrodotoxin (TTX) which blocks the TTX-sensitive fast Nav 1.6 and Nav 1.7 channels but not the TTX-resistant slow Nav 1.8 channel. PHN-associated VZV sodium current increases were therefore mediated in part by the Nav 1.6 and Nav 1.7 sodium ion channels. An additional observation was a modest increase in message levels of both Nav1.6 and Nav1.7 mRNA but not Nav 1.8 in PHN virally infected cells

Orbital Angular Momentum-based Space Division Multiplexing for High-capacity Underwater Optical Communications

To increase system capacity of underwater optical communications, we employ the spatial domain to simultaneously transmit multiple orthogonal spatial beams, each carrying an independent data channel. In this paper, we multiplex and transmit four green orbital angular momentum (OAM) beams through a single aperture. Moreover, we investigate the degrading effects of scattering/turbidity, water current, and thermal gradient-induced turbulence, and we find that thermal gradients cause the most distortions and turbidity causes the most loss. We show systems results using two different data generation techniques, one at 1064 nm for 10-Gbit/s/beam and one at 520 nm for 1-Gbit/s/beam, we use both techniques since present data-modulation technologies are faster for infrared (IR) than for green. For the higher-rate link, data is modulated in the IR, and OAM imprinting is performed in the green using a specially-designed metasurface phase mask. For the lower rates, a green laser diode is directly modulated. Finally, we show that inter-channel crosstalk induced by thermal gradients can be mitigated using multi-channel equalisation processing.Comment: 26 pages, 5 figure

Orbital angular momentum beams generated by passive dielectric phase masks and their performance in a communication link

We demonstrate the generation of orbital angular momentum (OAM) beams using high-efficient polarization-insensitive phase masks. The OAM beams generated by the phase masks are characterized in terms of their tolerance to misalignment (lateral displacement or tilt) between the incident beam and phase mask. For certain scenarios, our results show that (a) when the tilt angle is within the range of −20 to +20  deg, the crosstalk among modes is less than −15  dB; and (b) lateral displacement of 0.3 mm could cause a large amount of power leaked to adjacent modes. Finally, OAM beams generated by the phase masks are demonstrated over a two-channel OAM-multiplexing link, each channel carrying a 40 Gbit/s data stream. An optical signal-to-noise-ratio (OSNR) penalty of ∼1 dB is measured without crosstalk at the bit error rate (BER) of 3.8 × 10^(−3). With crosstalk, an OSNR penalty of <1.5  dB<1.5  dB is observed at the same BER