Star formation rates on global and cloud scales within the Galactic Centre

The environment within the inner few hundred parsecs of the Milky Way, known as the "Central Molecular Zone" (CMZ), harbours densities and pressures orders of magnitude higher than the Galactic Disc; akin to that at the peak of cosmic star formation (Kruijssen & Longmore 2013). Previous studies have shown that current theoretical star-formation models under-predict the observed level of star-formation (SF) in the CMZ by an order of magnitude given the large reservoir of dense gas it contains. Here we explore potential reasons for this apparent dearth of star formation activity

Star formation rates and efficiencies in the Galactic Centre

The inner few hundred parsecs of the Milky Way harbours gas densities, pressures, velocity dispersions, an interstellar radiation field and a cosmic ray ionisation rate orders of magnitude higher than the disc; akin to the environment found in star-forming galaxies at high-redshift. Previous studies have shown that this region is forming stars at a rate per unit mass of dense gas which is at least an order of magnitude lower than in the disc, potentially violating theoretical predictions. We show that all observational star formation rate diagnostics - both direct counting of young stellar objects and integrated light measurements - are in agreement within a factor two, hence the low star formation rate is not the result of the systematic uncertainties that affect any one method. As these methods trace the star formation over different timescales, from $0.1 - 5$ Myr, we conclude that the star formation rate has been constant to within a factor of a few within this time period. We investigate the progression of star formation within gravitationally bound clouds on $\sim$ parsec scales and find $1 - 4$ per cent of the cloud masses are converted into stars per free-fall time, consistent with a subset of the considered "volumetric" star formation models. However, discriminating between these models is obstructed by the current uncertainties on the input observables and, most importantly and urgently, by their dependence on ill-constrained free parameters. The lack of empirical constraints on these parameters therefore represents a key challenge in the further verification or falsification of current star formation theories

Investigating the structure and fragmentation of a highly filamentary IRDC

We present 3.7 arcsec (~0.05 pc) resolution 3.2 mm dust continuum observations from the IRAM PdBI, with the aim of studying the structure and fragmentation of the filamentary Infrared Dark Cloud G035.39-00.33. The continuum emission is segmented into a series of 13 quasi-regularly spaced (~0.18pc) cores, following the major axis of the IRDC. We compare the spatial distribution of the cores with that predicted by theoretical work describing the fragmentation of hydrodynamic fluid cylinders, finding a significant (factor of ~8) discrepancy between the two. Our observations are consistent with the picture emerging from kinematic studies of molecular clouds suggesting that the cores are harboured within a complex network of independent sub-filaments. This result emphasises the importance of considering the underlying physical structure, and potentially, dynamically important magnetic fields, in any fragmentation analysis. The identified cores exhibit a range in (peak) beam-averaged column density ($3.6{\rm x}10^{23}{\rm cm}^{-2}<N_{H,c}<8.0{\rm x}10^{23}{\rm cm}^{-2}$), mass ($8.1M_{\odot}<M_{c}<26.1M_{\odot}$), and number density ($6.1{\rm x}10^{5}{\rm cm}^{-3}<n_{H, c, eq}<14.7{\rm x}10^{5}{\rm cm}^{-3}$). Two of these cores, dark in the mid-infrared, centrally-concentrated, monolithic (with no traceable substructure at our PdBI resolution), and with estimated masses of the order ~20-25$M_{\odot}$, are good candidates for the progenitors of intermediate-to-high-mass stars. Virial parameters span a range $0.2<\alpha_{\rm vir}<1.3$. Without additional support, possibly from dynamically important magnetic fields with strengths of the order 230$\mu$G<B<670$\mu$G, the cores are susceptible to gravitational collapse. These results may imply a multi-layered fragmentation process, which incorporates the formation of sub-filaments, embedded cores, and the possibility of further fragmentation

The age of anxiety? It depends where you look: changes in STAI trait anxiety, 1970–2010

Purpose Population-level surveys suggest that anxiety has been increasing in several nations, including the USA and UK. We sought to verify the apparent anxiety increases by looking for systematic changes in mean anxiety questionnaire scores from research publications. Methods We analyzed all available mean State–Trait Anxiety Inventory scores published between 1970 and 2010. We collected 1703 samples, representing more than 205,000 participants from 57 nations. Results Results showed a significant anxiety increase worldwide, but the pattern was less clear in many individual nations. Our analyses suggest that any increase in anxiety in the USA and Canada may be limited to students, anxiety has decreased in the UK, and has remained stable in Australia. Conclusions Although anxiety may have increased worldwide, it might not be increasing as dramatically as previously thought, except in specific populations, such as North American students. Our results seem to contradict survey results from the USA and UK in particular. We do not claim that our results are more reliable than those of large population surveys. However, we do suggest that mental health surveys and other governmental sources of disorder prevalence data may be partially biased by changing attitudes toward mental health: if respondents are more aware and less ashamed of their anxiety, they are more likely to report it to survey takers. Analyses such as ours provide a useful means of double-checking apparent trends in large population surveys

Using young massive star clusters to understand star formation and feedback in high-redshift-like environments

The formation environment of stars in massive stellar clusters is similar to the environment of stars forming in galaxies at a redshift of 1 - 3, at the peak star formation rate density of the Universe. As massive clusters are still forming at the present day at a fraction of the distance to high-redshift galaxies they offer an opportunity to understand the processes controlling star formation and feedback in conditions similar to those in which most stars in the Universe formed. Here we describe a system of massive clusters and their progenitor gas clouds in the centre of the Milky Way, and outline how detailed observations of this system may be able to: (i) help answer some of the fundamental open questions in star formation and (ii) quantify how stellar feedback couples to the surrounding interstellar medium in this high-pressure, high-redshift analogue environment

Microbial ligand costimulation drives neutrophilic steroid-refractory asthma

Funding: The authors thank the Wellcome Trust (102705) and the Universities of Aberdeen and Cape Town for funding. This research was also supported, in part, by National Institutes of Health GM53522 and GM083016 to DLW. KF and BNL are funded by the Fonds Wetenschappelijk Onderzoek, BNL is the recipient of an European Research Commission consolidator grant and participates in the European Union FP7 programs EUBIOPRED and MedALL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.

Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes. Here, we identified a large-scale association between multiple coordinated blood leukocyte gene coexpression modules and the multivariate functional neuroimaging (fMRI) response to speech. Gene coexpression modules associated with the multivariate fMRI response to speech were different for all pairwise comparisons between typically developing toddlers and toddlers with ASD and poor versus good early language outcome. Associated coexpression modules were enriched in genes that are broadly expressed in the brain and many other tissues. These coexpression modules were also enriched in ASD-associated, prenatal, human-specific, and language-relevant genes. This work highlights distinctive neurobiology in ASD subtypes with different early language outcomes that is present well before such outcomes are known. Associations between neuroimaging measures and gene expression levels in blood leukocytes may offer a unique in vivo window into identifying brain-relevant molecular mechanisms in ASD

Eosinophil and T Cell Markers Predict Functional Decline in COPD Patients

BACKGROUND. The major marker utilized to monitor COPD patients is forced expiratory volume in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict subsequent decline. Recent studies indicate that T lymphocytes and eosinophils are important determinants of disease stability in COPD. We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease. METHODS. Baseline lung lavage and plasma samples were collected from COPD subjects with moderately severe airway obstruction and emphysematous changes on chest CT. The study participants were former smokers who had not had a disease exacerbation within the past six months or used steroids within the past two months. Those subjects who demonstrated stable disease over the following six months (ΔFEV1 % predicted = 4.7 ± 7.2; N = 34) were retrospectively compared with study participants who experienced a rapid decline in lung function (ΔFEV1 % predicted = -16.0 ± 6.0; N = 16) during the same time period and with normal controls (N = 11). Plasma and lung lavage cytokines were measured from clinical samples using the Luminex multiplex kit which enabled the simultaneous measurement of several T cell and eosinophil related cytokines. RESULTS AND DISCUSSION. Stable COPD participants had significantly higher plasma IL-2 levels compared to participants with rapidly progressive COPD (p = 0.04). In contrast, plasma eotaxin-1 levels were significantly lower in stable COPD subjects compared to normal controls (p < 0.03). In addition, lung lavage eotaxin-1 levels were significantly higher in rapidly progressive COPD participants compared to both normal controls (p < 0.02) and stable COPD participants (p < 0.05). CONCLUSION. These findings indicate that IL-2 and eotaxin-1 levels may be important markers of disease stability in advanced emphysema patients. Prospective studies will need to confirm whether measuring IL-2 or eotaxin-1 can identify patients at risk for rapid disease progression.National Heart, Lung, and Blood Institute (NO1-HR-96140, NO1-HR-96141-001, NO1-HR-96144, NO1-HR-96143; NO1-HR-96145; NO1-HR-96142, R01HL086936-03); The Flight Attendant Medical Research Institute; the Jo-Ann F. LeBuhn Center for Chest Diseas

The Separation From Nature: Implications On Human Well-Being And The Future Of Our Planet

Research suggests that the amount of time people spend outside is the lowest it has been in human history (Larson and Verma, 1999; Louv, 2008; Pergams and Zaradic, 2006). Spending time outside is valuable and plays a great importance in childhood development. However, the decline in time people spend in time is adversely affecting childhood development, human health, and well-being (Barker et al., 2014; Moffitt et al., 2010). Three questions focus my research. Why is spending time outside is crucial for human well-being and the well-being of our planet? What factors are driving the decline in human time spent in nature? What can we do to mend the gap between humans and nature

The effect of dietary fat on dopamine neurotransmission

Emerging evidence has revealed that obesity and diets high in saturated fat are linked with pathophysiological changes in the dopaminergic reward system that disrupt satiety signals governing homeostatic food intake. Diets high in saturated fat are also implicated in the development of a metabolic syndrome-like phenotype characterized by obesogenic weight gain, insulin resistance, and chronic inflammation. While there is evidence that anti-inflammatory unsaturated fats promote healthier metabolic profiles and brain health, little is known about the effects of diets high in unsaturated fat on dopamine neurotransmission which plays a role in feeding and satiety circuits. We sought to determine whether a diet high in unsaturated fat, in contrast to saturated fat, would prevent the development of a metabolic disorders and preserve normal dopamine function. To examine this, male C57BL/6 mice were fed, ad libitum, a low-fat (LF) control diet or a nutrient-matched diet high in either saturated fat (SFD) or unsaturated flaxseed oil (FSO) for six weeks. We measured food intake and body weight throughout the dietary intervention and after six weeks we assessed metabolic dysfunction with glucose tolerance tests and locomotor behaviors in an open field test. We subsequently measured sub-second dopamine release and uptake from dopamine neurons using ex-vivo Fast Scan Cyclic Voltammetry in the nucleus accumbens (NAc). Dopamine kinetics in response to the dopamine D2/D3 receptor agonist quinpirole was also measured to assess dopamine receptor function. In order to assess the relationship between dietary fat, inflammation, and dopamine neurotransmission, the pro-inflammatory cytokine, interleukin-6 (IL-6) was also measured in the NAc. Mice fed a SFD consumed significantly more food and gained significantly more weight compared to their LF-fed counterparts. In addition, unlike the LF group, the SFD group displayed anxiogenic locomotor behaviors in open field tests. Interestingly, the FSO group consumed the same amount of food as the SFD group; however, the FSO diet attenuated weight gain and preserved normal blood glucose regulation and locomotor behaviors. Significantly, the SFD group also exhibited dampened phasic dopamine release, impaired dopamine uptake and increased sensitivity to quinpirole, all of which was prevented with the FSO diet. There was also a negative association between dopamine uptake and IL-6 in the SFD group suggesting IL-6 selectively corresponded with reduced dopamine uptake in mice fed saturated versus unsaturated fat. Collectively, we demonstrate that different types of dietary fat have substantially different effects on metabolic phenotype and dopamine terminal regulation. In contrast to a diet high in saturated fat, a diet high in unsaturated fat preserved both normal metabolic and behavioral parameters as well as dopamine signaling in the NAc