Investigation of the Selective Laser Melting process with tungsten metal powder

Selective Laser Melting (SLM) is a leading Additive Manufacturing (AM) technology used for high value low volume manufacturing. It is currently used commercially for processing of steels, titanium, nickel- and aluminum-alloys in medical and aerospace industries. It is not used currently for refractory metals, mainly because of the intrinsic problems of processing higher melting point materials but also due to the process being driven slowly by the industries involved. Successful SLM processing requires development of material specific processing parameters that differ between materials and so the system must be developed to match each material used. In this study, processing of tungsten is considered for the production of solid and porous parts. The study also considers the role of the pure tungsten powder interaction with processing conditions within SLM. The process quality is quantified in terms of porosity, integrity and microstructure. The reasons why the parameters used have the effects observed is discussed and the effects on future development of this technology in this field is discussed

Mind Your Meds: Safe Opioid Disposal Awareness

Driven by the effects of the opioid epidemic on friends, family members, students, and patients, members of the 2019 GEHLI Team “Mission Possible” are dedicated to bolstering educational awareness of safe leftover opioid disposal methods to decrease the supply of opioids in our community. On average, over 2/3 of opioid prescription medications are leftover and lead to later misuse or abuse (JAMA Survey). Despite a decrease in prescription writing for pain medication over the years, the mortality rate from overdose, and the rate of infants born to mothers with opioid abuse continues to steadily increase in Virginia (VDH). Team Mission Possible seeks to promote awareness of both the need and resources available for safe opioid disposal by educating prescribers in the VCU Health system and spreading knowledge to VCU patients, students, faculty, staff, and members of the surrounding community through: educational events on the Monroe Park and Medical campuses; teaming up with Miss Virginia’s “Mind your Meds campaign”; live Facebook interviews; and educational flyers

A Bridge to the Future: Cultivating Academic Leadership Today for Better Communities Tomorrow

The purpose of this project is to develop a plan for expanding and funding the Grace E. Harris Leadership Institute (GEHLI). Currently, teams of leadership scholars selected from Virginia Commonwealth University (VCU) develop projects relating to the academic community in addition to studying the dynamics of effective leadership. Consistent with VCU\u27s vision of partnering with and service to metropolitan Richmond, we propose that future teams of leadership scholars develop outreach projects that involve and benefit the local community. The training in which scholars would participate would include learning about the Richmond community, its needs and goals, as well as the dynamics of leadership. Project teams would collaborate with community groups or leaders, thereby strengthening the bonds between VCU and the community, and providing public service, in accordance with VCU\u27s mission. Projects might include education, outreach, fundraising, mentoring, or research that would benefit Richmond and provide scholars with opportunities to network with local leaders. Financial and philanthropic resources will be investigated and a list of potential funding organizations will be generated

Multi-Bunch Instability Diagnostics via Digital Feedback Systems

Longitudinal feedback systems based on a common programmable DSP architecture have been commissioned at 4 laboratories. In addition to longitudinal feedback and beam diagnostics these exible systems have been programmed to provide diagnostics for tranverse motion. The diagnostic functions are based on transient domain techniques which record the response of every bunch while the feedback system manipulates the beam. Operational experience from 4 installations is illustrated via experimental results from PEP-II, DA NE, ALS and SPEAR. Modal growth and damping rates for transverse and longitudinal planes are measured via short (20 ms) transient excitations for unstable and stable coupled-bunch modes. Data from steady-state measurements are used to identify unstable modes, noise-driven beam motion, and noise sources. Techniques are illustrated which allow the prediction of instability thresholds from low-current measurements of stable beams. Tranverse bunch train grow-damp sequences which measure the time evolution of instabilities along the bunch train are presented and compared to signatures expected from ion and fast ion instabilities. Invited talk presented at the IEEE Particle Accelerator Conference (PAC99

Association of Clinical Factors and Therapeutic Strategies With Improvements in Survival Following Non-ST-Elevation Myocardial Infarction, 2003-2013.

Importance: International studies report a decline in mortality following non–ST-elevation myocardial infarction (NSTEMI). Whether this is due to lower baseline risk or increased utilization of guideline-indicated treatments is unknown. Objective: To determine whether changes in characteristics of patients with NSTEMI are associated with improvements in outcomes. Design, Setting, and Participants: Data on patients with NSTEMI in 247 hospitals in England and Wales were obtained from the Myocardial Ischaemia National Audit Project between January 1, 2003, and June 30, 2013 (final follow-up, December 31, 2013). Exposures: Baseline demographics, clinical risk (GRACE risk score), and pharmacological and invasive coronary treatments. Main Outcomes and Measures: Adjusted all-cause 180-day postdischarge mortality time trends estimated using flexible parametric survival modeling. Results: Among 389 057 patients with NSTEMI (median age, 72.7 years [IQR, 61.7-81.2 years]; 63.1% men), there were 113 586 deaths (29.2%). From 2003-2004 to 2012-2013, proportions with intermediate to high GRACE risk decreased (87.2% vs 82.0%); proportions with lowest risk increased (4.2% vs 7.6%; P= .01 for trend). The prevalence of diabetes, hypertension, cerebrovascular disease, chronic obstructive pulmonary disease, chronic renal failure, previous invasive coronary strategy, and current or ex-smoking status increased (all P < .001). Unadjusted all-cause mortality rates at 180 days decreased from 10.8% to 7.6% (unadjusted hazard ratio [HR], 0.968 [95% CI, 0.966-0.971]; difference in absolute mortality rate per 100 patients [AMR/100], −1.81 [95% CI, −1.95 to −1.67]). These findings were not substantially changed when adjusted additively by baseline GRACE risk score (HR, 0.975 [95% CI, 0.972-0.977]; AMR/100, −0.18 [95% CI, −0.21 to −0.16]), sex and socioeconomic status (HR, 0.975 [95% CI, 0.973-0.978]; difference in AMR/100, −0.24 [95% CI, −0.27 to −0.21]), comorbidities (HR, 0.973 [95% CI, 0.970-0.976]; difference in AMR/100, −0.44 [95% CI, −0.49 to −0.39]), and pharmacological therapies (HR, 0.972 [95% CI, 0.964-0.980]; difference in AMR/100, −0.53 [95% CI, −0.70 to −0.36]). However, the direction of association was reversed after further adjustment for use of an invasive coronary strategy (HR, 1.02 [95% CI, 1.01-1.03]; difference in AMR/100, 0.59 [95% CI, 0.33-0.86]), which was associated with a relative decrease in mortality of 46.1% (95% CI, 38.9%-52.0%). Conclusions and Relevance: Among patients hospitalized with NSTEMI in England and Wales, improvements in all-cause mortality were observed between 2003 and 2013. This was significantly associated with use of an invasive coronary strategy and not entirely related to a decline in baseline clinical risk or increased use of pharmacological therapies

Dietary elimination of children with food protein induced gastrointestinal allergy – micronutrient adequacy with and without a hypoallergenic formula?

Background: The cornerstone for management of Food protein-induced gastrointestinal allergy (FPGIA) is dietary exclusion; however the micronutrient intake of this population has been poorly studied. We set out to determine the dietary intake of children on an elimination diet for this food allergy and hypothesised that the type of elimination diet and the presence of a hypoallergenic formula (HF) significantly impacts on micronutrient intake. Method: A prospective observational study was conducted on children diagnosed with FPIGA on an exclusion diet who completed a 3 day semi-quantitative food diary 4 weeks after commencing the diet. Nutritional intake where HF was used was compared to those without HF, with or without a vitamin and mineral supplement (VMS). Results: One-hundred-and-five food diaries were included in the data analysis: 70 boys (66.7%) with median age of 21.8 months [IQR: 10 - 67.7]. Fifty-three children (50.5%) consumed a HF and the volume of consumption was correlated to micronutrient intake. Significantly (p <0.05) more children reached their micronutrient requirements if a HF was consumed. In those without a HF, some continued not to achieve requirements in particular for vitamin D and zinc, in spite of VMS. Conclusion: This study points towards the important micronutrient contribution of a HF in children with FPIGA. Children, who are not on a HF and without a VMS, are at increased risk of low intakes in particular vitamin D and zinc. Further studies need to be performed, to assess whether dietary intake translates into actual biological deficiencies

Timeliness of Clinic Attendance is a good predictor of Virological Response and Resistance to Antiretroviral drugs in HIV-infected patients

Ensuring long-term adherence to therapy is essential for the success of HIV treatment. As access to viral load monitoring and genotyping is poor in resource-limited settings, a simple tool to monitor adherence is needed. We assessed the relationship between an indicator based on timeliness of clinic attendance and virological response and HIV drug resistance

Multi-Bunch Longitudinal Dynamics and Diagnostics via a Digital

A bunch-by-bunch longitudinal feedback system based on a programmable DSP architecture is used to study coupled-bunch motion and its sources. Experimental results are presented from PEP-II, DA NE, ALS and SPEAR to highlight the operational experience from 4 installations, plus show novel accelerator diagnostics possible with the digital processing system. Modal growth and damping rates are measured via short ( 20 ms) transient recordings for unstable and stable coupled-bunch modes. Data from steady-state measurements are used to identify unstable modes and noise-driven beam motion. Anovel impedance measurement technique is presented which reveals the longitudinal impedance as a function of frequency. This technique uses the measured synchronous phase and charge of every bucket to calculate the impedance seen by the beam at revolution harmonics

The attitudinal and physical relationships of man to the motorcycle as a problem in painting

I am presenting in my paintings the figurative elements of man and motorcycle as a series of juxtapositions. Each painting is composed of two panels: one depicting some aspect of man; the other providing some view of the machine. I have examined man and motorcycle with an eye for those qualities which I felt best related them in attitude or physical similarities. They are not to be necessarily related to each other in function, as wheel to leg or foot or handlebar to hand, but quite frequently to depict unrelated functional configurations. Concern for what either subject is doing has no place in my painting. The subjects are merely "things" to be inspected as one might do with museum articles whose functions are unknown or unimportant; but which might have physical qualities which produce an element of interest. The motorcycles of the paintings are not "working models"; you are not to read them as such. You would be hard put to identify precisely the mechanical aspects of the machine found in the paintings, because a precise blueprint of this was not my intention at all

The Progression of Women in Legislation: From Property to People

In this thesis, the transformation of the legal status of women will be examined. Beginning with a discussion of the common law foundations and focusing especially on coverture, this paper will provide a history of how women’s place in society developed through legislation as they gradually evolved from being recognized as the property of their husbands to being sovereign individuals. This progression for women was slow, and remains incomplete. Despite progress, echoes of patriarchal oppression still exist in law today