Retinal processes involved in the evoked cortical potential to patterned stimuli

The purpose of this investigation was to study the underlying physiological processes involved in the evoked potential to patterned visual stimulation. Specifically, the study was designed to assess the role of the photopic and scotopic visual systems as mediatory processes subserving occipitally elicited potentials to a series of checkerboard patterns. In addition, it was hoped that the research would provide further information with respect to the hypothetical mechanisms of lateral inhibition and receptive field size and their contribution to complex visual processes. Six subjects participated in the experiment. Evoked potentials were recorded to a series of patterned stimuli that were illuminated with red and blue flashes presented to central and peripheral retinal sites against high and low levels of background luminance. Statistical analysis of the data revealed significant relations between evoked potential amplitude and the main effects of background, site, and check-size. Amplitude was also significantly related to the interaction effects of background x site, check-size x background, check-size x color, and site x color x background. Discussion of the results was in terms of the differential functional behavior of photopic and scotopic visual processes. Several comments were directed to the possible importance of lateral inhibition and receptive field size in the generation of these data

A practical approach to vitamin and mineral supplementation in food allergic children

The management of food allergy in children requires elimination of the offending allergens, which significantly contribute to micronutrient intake. Vitamin and mineral supplementation are commonly suggested as part of dietary management. However a targeted supplementation regime requires a complete nutritional assessment, which includes food diaries. Ideally these should be analysed using a computerised program, but are very time consuming. We therefore set out to evaluate current practice of vitamin and mineral supplementation in a cohort of children with non-Immunoglobulin E (IgE) mediated food allergies

Profile of Public Health Leadership

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Teacher Preference Of Administrator’s Transformational Or Transactional Leadership Style: A Regression Study

This quantitative study determined the relationship between leadership dispositions and behaviors North Carolina teachers and school administrators deemed essential in leadership development and creating a positive school climate. North Carolina teachers and administrators among the chosen eight North Carolina School Districts were surveyed concerning Marzano's 21 responsibilities of school leaders. The quantitative method featured a cross-sectional survey to investigate how the administration's transformational or transactional dispositions were preferred and influenced the teacher's and administrator's perceptions of school climate. Binary logistic regression was employed to infer relationships between the dependent and independent variables in six models. Results showed significant relationships between predictor and criterion variables, including good school climate and preference for leadership styles. Implications for practice included several recommendations for school districts and their leaders. Further research recommendations also stemmed from this project to further examine variables and employ a phenomenological or narrative inquiry design to study several of the predictor variables that would not lend themselves to further quantitative analysis

A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis

© 2016 cThe Author(s). Helminth parasites secrete molecules that potently modulate the immune responses of their hosts and, therefore, have potential for the treatment of immune-mediated human diseases. FhHDM-1, a 68-mer peptide secreted by the helminth parasite Fasciola hepatica, ameliorated disease in two different murine models of autoimmunity, type 1 diabetes and relapsing-remitting immune-mediated demyelination. Unexpectedly, FhHDM-1 treatment did not affect the proliferation of auto-antigen specific T cells or their production of cytokines. However, in both conditions, the reduction in clinical symptoms was associated with the absence of immune cell infiltrates in the target organ (islets and the brain tissue). Furthermore, after parenteral administration, the FhHDM-1 peptide interacted with macrophages and reduced their capacity to secrete pro-inflammatory cytokines, such as TNF and IL-6. We propose this inhibition of innate pro-inflammatory immune responses, which are central to the initiation of autoimmunity in both diseases, prevented the trafficking of autoreactive lymphocytes from the periphery to the site of autoimmunity (as opposed to directly modulating their function per se), and thus prevented tissue destruction. The ability of FhHDM-1 to modulate macrophage function, combined with its efficacy in disease prevention in multiple models, suggests that FhHDM-1 has considerable potential as a treatment for autoimmune diseases

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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The immunology and genetics of resistance of sheep to Teladorsagia circumcincta

Teladorsagia circumcincta is one of the most economically important gastrointestinal nematode parasites of sheep in cool temperate regions, to which sheep show genetically-varying resistance to infection. This is a very common parasite and viable sheep production requires the extensive use of anthelmintic drugs. However, the emergence of drug-resistant parasites has stimulated the search for alternative control strategies to curb production losses. Lambs become infected soon after weaning and begin to control parasite burden within 8-10 weeks of continual infection. This control is an acquired characteristic mediated by the development of parasite-specific antibodies. This paper describes the immunology associated with resistance and susceptibility, focussing on differential T cell activation that regulates the production of specific effector mechanisms. It continues by summarizing the methods used to identify genes that could be exploited as molecular markers of selection for resistance. In particular it focusses on the link between understanding the molecular immunology of infection and the identification of candidate genes for selection

Integrated Virtual Learning Environment for Cybersecurity (IVLE4C)

The authors are working to improve students’ understanding of and classroom experience with enterprise cybersecurity. Central to this effort is development of the Integrated Virtual Learning Environment for Cybersecurity (IVLE4C), a teaching and learning tool intended for use by both teachers and students. The authors are endeavoring to incorporate into IVLE4C best practices from the knowledge domains of education, model-based systems engineering, and cybersecurity. A modern digital enterprise is a large-scale, complex system of systems. Enterprise cybersecurity is a special subset of the larger knowledge domain that merits special consideration when instructing students who lack relevant work experience. This lack of work experience creates a gap in students’ knowledge about the structure, operation, and control of a modern digital enterprise. Our guiding precept – coined Greer’s Rule of Thumb – is that: it is impossible to defend what cannot be visualized and described. Therefore, it is essential to address the student enterprise knowledge gap before attempting to teach the means for assuring enterprise cybersecurity. Viste and Skartveit (2004) propose using an interactive virtual learning environment with reality abstraction models when teaching the structure, operation, and control of a large-scale complex system. The creation of a virtual model enables a modern digital enterprise to be brought into the classroom. This allows for learning that is complementary to experiential learning that occurs during an internship and, possibly, a viable alternative when internships are unavailable or come later in a curriculum path. Once developed, a library of models representing different digital enterprise types can be used to accelerate student enterprise cybersecurity education in a controlled classroom environment. During the presentation, the authors will provide an update on the use of model-based system engineering practices and how they are being integrated into IVLE4C for developing a tailored, enterprise risk management strategy. This approach is consistent with guidance provided in the NIST Cybersecurity Framework. Research shows model-based systems engineering is increasingly being used for developing engineered cybersecurity solutions. An example of this is research performed by Robles-Ramirez et.al. (2020) on the application of model-based Cybersecurity Engineering for Connected and Automated Vehicles. Key is the notion of turning a cyber-attack surface into a trust boundary at targeted levels. IVLE4C version 1.0 is currently being used to teach Cyber Supply Chain Security at UNCW. Version 2.0 is a dynamic data driven web application, that is being developed for teaching Enterprise Security

A parallel-group randomized clinical trial of individually tailored, multidisciplinary, palliative rehabilitation for patients with newly diagnosed advanced cancer: the Pal-Rehab study protocol

BACKGROUND: The effect of early palliative care and rehabilitation on the quality of life of patients with advanced cancer has been only sparsely described and needs further investigation. In the present trial we combine elements of early, specialized palliative care with cancer rehabilitation in a 12-week individually tailored, palliative rehabilitation program initiated shortly after a diagnosis of advanced cancer.METHODS: This single center, randomized, controlled trial will include 300 patients with newly diagnosed advanced cancer recruited from the Department of Oncology, Vejle Hospital. The patients are randomized to a specialized palliative rehabilitation intervention integrated in standard oncology care or to standard oncology care alone. The intervention consists of a multidisciplinary group program, individual consultations, or a combination of both. At baseline and after six and 12 weeks the patients will be asked to fill out questionnaires on symptoms, quality of life, and symptoms of depression and anxiety. Among the symptoms and problems assessed, patients are asked to indicate the problem they need help with to the largest extent. The effect of the intervention on this problem is the primary outcome measure of the study. Secondary outcome measures include survival and economic consequences.DISCUSSION: To our knowledge the Pal-Rehab study is the first randomized, controlled, phase III trial to evaluate individually tailored, palliative rehabilitation in standard oncology care initiated shortly after an advanced cancer diagnosis. The study will contribute with evidence on the effectiveness of implementing early palliative care in standard oncology treatment and hopefully offer new knowledge and future directions as to the content of palliative rehabilitation programs.TRIAL REGISTRATION: Clinicaltrials.gov Identifier: NCT02332317 , registered retrospectively on December 30, 2014. One study participant had been enrolled at the time.</p