Algorithms for enumerating invariants and extensions of local fields

There are many computationally difficult problems in the study of p-adic fields, among them the classification of field extensions and the decomposition of global ideals. The main goal of this work is present efficient algorithms, leveraging the Newton polygons and residual polynomials, to solve many of these problems faster and more efficiently than present methods. Considering additional invariants, we extend Krasner's mass formula, dramatically improve general extension enumeration using the reduced Eisenstein polynomials of Monge, and provide a detailed account of algorithms that compute Okutsu invariants, which have many uses, through the lens of partitioning the set of zeros of polynomials

Collective bargaining for public school teachers in North Carolina : a study of major negotiable issues which may confront local boards of education in large units

The purpose of this study is to investigate and analyze major negotiable issues which are confronting school boards nationwide and which may confront schools boards in large administrative units within North Carolina. The following issues are considered: major national collective bargaining legislation and developing legislative trends involving public school teachers and having implications for North Carolina; the effects of legalized collective bargaining on existing statutes pertaining to management rights; an analysis of the major non-budget issues at the local board level; and an analysis of the major budget issues confronting school boards. The State of North Carolina at the present time has statutes forbidding the implementation of collective bargaining contracts between public school teachers and school boards. The educational hierarchy is receiving increased pressure from teacher organizations within the state to include the teachers in educational decisions which pertain to their wages, hours, and conditions of employment

Entangled Histories: An Analysis Of The Anglophone Histories Of Science In Latin America From Dependence Decoloniality, 1950-Present

Science in Latin America has a rich, complex history characterized by a hybridization of multiple Indigenous, Creole, imperial Iberian and Western/Northern knowledge practices. As a result of these entangled histories, Latin American science does not fit easily into the standard periodization of Western histories of science, nor into traditional Latin American historical periodization. This inability to effectively categorize and constrain the heterogeneous histories of Latin American science has meant that these fascinating narratives have been widely ignored by historians in the West. After reading widely from what has been published over the years, some patterns began to emerge in the ways in which Western-located academics have considered the subject. This thesis examines how Anglophone historians have written about science in Latin America over the previous 70 years, from the early narratives of dependence, through social histories and constructivism, to more recent postcolonial histories and decolonial standpoints. The hope is that through such historical self-reflection, Anglophone historians will more readily incorporate heterogeneous and pluriversal perspectives on science in Latin America in their research and in their curriculums, and also begin to publish works that are accessible to diverse peoples outside of niche academic circles

NFATc1 controls the cytotoxicity of CD8+ T cells

NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8+ T cells required for optimal response to bacteria and tumor cells

Angular and Current-Target Correlations in Deep Inelastic Scattering at HERA

Correlations between charged particles in deep inelastic ep scattering have been studied in the Breit frame with the ZEUS detector at HERA using an integrated luminosity of 6.4 pb-1. Short-range correlations are analysed in terms of the angular separation between current-region particles within a cone centred around the virtual photon axis. Long-range correlations between the current and target regions have also been measured. The data support predictions for the scaling behaviour of the angular correlations at high Q2 and for anti-correlations between the current and target regions over a large range in Q2 and in the Bjorken scaling variable x. Analytic QCD calculations and Monte Carlo models correctly describe the trends of the data at high Q2, but show quantitative discrepancies. The data show differences between the correlations in deep inelastic scattering and e+e- annihilation.Comment: 26 pages including 10 figures (submitted to Eur. J. Phys. C

Valproic acid and fatalities in children: a review of individual case safety reports in VigiBase

Introduction Valproic acid is an effective first line drug for the treatment of epilepsy. Hepatotoxicity is a rare and potentially fatal adverse reaction for this medicine. Objective Firstly to characterise valproic acid reports on children with fatal outcome and secondly to determine reporting over time of hepatotoxicity with fatal outcome. Methods Individual case safety reports (ICSRs) for children ≤17 years with valproic acid and fatal outcome were retrieved from the WHO Global ICSR database, VigiBase, in June 2013. Reports were classified into hepatotoxic reactions or other reactions. Shrinkage observed-to-expected ratios were used to explore the relative reporting trend over time and for patient age. The frequency of polytherapy, i.e. reports with more than one antiepileptic medicine, was investigated. Results There have been 268 ICSRs with valproic acid and fatal outcome in children, reported from 25 countries since 1977. A total of 156 fatalities were reported with hepatotoxicity, which has been continuously and disproportionally reported over time. There were 31 fatalities with pancreatitis. Other frequently reported events were coma/encephalopathy, seizures, respiratory disorders and coagulopathy. Hepatotoxicity was disproportionally and most commonly reported in children aged 6 years and under (104/156 reports) but affected children of all ages. Polytherapy was significantly more frequently reported for valproic acid with fatal outcome (58%) compared with non-fatal outcome (34%). Conclusion Hepatotoxicity remains a considerable problem. The risk appears to be greatest in young children (6 years and below) but can occur at any age. Polytherapy is commonly reported and seems to be a risk factor for hepatotoxicity, pancreatitis and other serious adverse drug reactions with valproic acid

Plastisol Foaming Process. Decomposition of the Foaming Agent, Polymer Behavior in the Corresponding Temperature Range and Resulting Foam Properties

The decomposition of azodicarbonamide, used as foaming agent in PVC - plasticizer (1/1) plastisols was studied by DSC. Nineteen different plasticizers, all belonging to the ester family, two being polymeric (polyadipates), were compared. The temperature of maximum decomposition rate (in anisothermal regime at 5 K min-1 scanning rate), ranges between 434 and 452 K. The heat of decomposition ranges between 8.7 and 12.5 J g -1. Some trends of variation of these parameters appear significant and are discussed in terms of solvent (matrix) and viscosity effects on the decomposition reactions. The shear modulus at 1 Hz frequency was determined at the temperature of maximum rate of foaming agent decomposition, and differs significantly from a sample to another. The foam density was determined at ambient temperature and the volume fraction of bubbles was used as criterion to judge the efficiency of the foaming process. The results reveal the existence of an optimal shear modulus of the order of 2 kPa that corresponds roughly to plasticizer molar masses of the order of 450 ± 50 g mol-1. Heavier plasticizers, especially polymeric ones are too difficult to deform. Lighter plasticizers such as diethyl phthalate (DEP) deform too easily and presumably facilitate bubble collapse

Correlation Of The Myers-Briggs Type Indicator To The Reported Overall Effectiveness Of Resident Assistants

In this study the problem under investigation is to determine if there is a relationship between an individual's psychological type and his or her effectiveness as a Resident Assistant