Levy model of cancer

A small portion of a tissue defines a microstate in gene expression space. Mutations, epigenetic events or external factors cause microstate displacements which are modeled by combining small independent gene expression variations and large Levy jumps, resulting from the collective variations of a set of genes. The risk of cancer in a tissue is estimated as the microstate probability to transit from the normal to the tumor region in gene expression space. The formula coming from the contribution of large Levy jumps seems to provide a qualitatively correct description of the lifetime risk of cancer, and reveals an interesting connection between the risk and the way the tissue is protected against infections.Comment: arXiv admin note: text overlap with arXiv:1507.0692

Lyapunov decay in quantum irreversibility

The Loschmidt echo -- also known as fidelity -- is a very useful tool to study irreversibility in quantum mechanics due to perturbations or imperfections. Many different regimes, as a function of time and strength of the perturbation, have been identified. For chaotic systems, there is a range of perturbation strengths where the decay of the Loschmidt echo is perturbation independent, and given by the classical Lyapunov exponent. But observation of the Lyapunov decay depends strongly on the type of initial state upon which an average is done. This dependence can be removed by averaging the fidelity over the Haar measure, and the Lyapunov regime is recovered, as it was shown for quantum maps. In this work we introduce an analogous quantity for systems with infinite dimensional Hilbert space, in particular the quantum stadium billiard, and we show clearly the universality of the Lyapunov regime.Comment: 8 pages, 6 figures. Accepted in Phil. Trans. R. Soc.

Relaxation of isolated quantum systems beyond chaos

In classical statistical mechanics there is a clear correlation between relaxation to equilibrium and chaos. In contrast, for isolated quantum systems this relation is -- to say the least -- fuzzy. In this work we try to unveil the intricate relation between the relaxation process and the transition from integrability to chaos. We study the approach to equilibrium in two different many body quantum systems that can be parametrically tuned from regular to chaotic. We show that a universal relation between relaxation and delocalization of the initial state in the perturbed basis can be established regardless of the chaotic nature of system.Comment: 4+ pages, 4 figs. Closest to published versio

N electrons in a quantum dot: Two-point Pade approximants

We present analytic estimates for the energy levels of N electrons (N = 2 - 5) in a two-dimensional parabolic quantum dot. A magnetic field is applied perpendicularly to the confinement plane. The relevant scaled energy is shown to be a smooth function of the parameter \beta=(effective Rydberg/effective dot energy)^{1/6}. Two-point Pade approximants are obtained from the series expansions of the energy near the oscillator ($\beta\to 0$) and Wigner ($\beta\to\infty$) limits. The approximants are expected to work with an error not greater than 2.5% in the entire interval $0\le\beta < \infty$.Comment: 27 pages. LaTeX. 6 figures not include

On the Lagrange and Markov Dynamical Spectra for Geodesic Flows in Surfaces with Negative Curvature

We consider the Lagrange and the Markov dynamical spectra associated to a geodesic flow on a surface of negative curvature. We show that for a large set of real functions on the unit tangent bundle and for typical metrics with negative curvature and finite volume, both the Lagrange and the Markov dynamical spectra have non-empty interior

New results on the spectroscopy of XYZ states from LHC experiments

The main results from LHC experiments on XYZ charmonium-like candidates are summarized.Comment: to appear in the proceedings of The 5th International Workshop on Charm Physics (Charm 2012

Preditores de fibrilação atrial de novo em unidade de cuidados intensivos não cardíaca

OBJECTIVE: To assess the predictors of de novo atrial fibrillation in patients in a non-cardiac intensive care unit. METHODS: A total of 418 hospitalized patients were analyzed between January and September 2016 in a non-cardiac intensive care unit. Clinical characteristics, interventions, and biochemical markers were recorded during hospitalization. In-hospital mortality and length of hospital stay in the intensive care unit were also evaluated. RESULTS: A total of 310 patients were included. The mean age of the patients was 61.0 ± 18.3 years, 49.4% were male, and 23.5% presented de novo atrial fibrillation. The multivariate model identified previous stroke (OR = 10.09; p = 0.016) and elevated levels of pro-B type natriuretic peptide (proBNP, OR = 1.28 for each 1,000pg/mL increment; p = 0.004) as independent predictors of de novo atrial fibrillation. Analysis of the proBNP receiver operating characteristic curve for prediction of de novo atrial fibrillation revealed an area under the curve of 0.816 (p 5,666pg/mL. There were no differences in mortality (p = 0.370), but the lengths of hospital stay (p = 0.002) and stay in the intensive care unit (p = 0.031) were higher in patients with de novo atrial fibrillation. CONCLUSIONS: A history of previous stroke and elevated proBNP during hospitalization were independent predictors of de novo atrial fibrillation in the polyvalent intensive care unit. The proBNP is a useful and easy- and quick-access tool in the stratification of atrial fibrillation risk.Objetivo: Avaliar quais os preditores de fibrilação atrial de novo em doentes de uma unidade de cuidados intensivos não cardíaca. Métodos: Foram analisados 418 doentes internados entre janeiro e setembro de 2016 em uma unidade de cuidados intensivos não cardíaca. Registaram-se as características clínicas, as intervenções efetuadas e os marcadores bioquímicos durante a internação. Avaliaram-se ainda a mortalidade hospitalar e o tempo de internação hospitalar e na unidade de cuidados intensivos. Resultados: Foram incluídos 310 doentes, com média de idades de 61,0 ± 18,3 anos, 49,4% do sexo masculino, 23,5% com fibrilação atrial de novo. O modelo multivariável identificou acidente vascular cerebral prévio (OR de 10,09; p = 0,016) e valores aumentados de proBNP (OR de 1,28 por cada aumento em 1.000pg/mL; p = 0,004) como preditores independentes de fibrilação atrial de novo. A análise por curva Característica de Operação do Receptor do proBNP para predição de fibrilação atrial de novo revelou área sob a curva de 0,816 (p 5.666pg/mL. Não se verificaram diferenças na mortalidade (p = 0,370), porém a duração da internação hospitalar (p = 0,002) e na unidade de cuidados intensivos (p = 0,031) foi superior nos doentes com fibrilação atrial de novo. Conclusões: História de acidente vascular cerebral prévio e proBNP elevado em internação constituíram preditores independentes de fibrilação atrial de novo na unidade de cuidados intensivos polivalente. O proBNP pode constituir ferramenta útil, de fácil e rápido acesso na estratificação do risco de fibrilação atrial.info:eu-repo/semantics/publishedVersio