On the Working of a Rotating Commutator

@IAC

SURVEY ON ROUTING METRICS AND ROUTING PROTOCOLS IN WIRELESS MESH NETWORKS

Today, Internet has become an indispensable part of our daily lives. It has a growing user community in many fields from banking transactions to online entertainment. It will be very efficient for users, as the next generation internet access becomes wireless like frequently used services such as cellular phones. But for providing this, a new network is needed to be designed or an existing network must be improved as well as making changes on infrastructure. At this point, mesh network infrastructure arises and offers more sophisticated internet access with less need. The most important advantage of mesh networks is the capability of working without infrastructure. Mesh networks are an additional access technology more than being a renewed one in the next generation wireless networks called 4G. In this study, wireless mesh networks base architecture and design factors are emphasized, current routing protocols that are used on wireless mesh networks and routing metrics on which these protocols are based, are explained. Finally, the performance effects of these protocols and metrics on different network topologies are referred.

Note on a New Rotating Commutator

This paper describe about the New Rotating Commutator.@IAC

Atmospheric Electric Potential Gradient at Bangalore,

This paper deals with Atmospheric Electric Potential Gradient at Bangalore@IAC

Capturing vehicular space headway using low-cost LIDAR and processing through ARIMA prediction modeling

The paper proposes a low-cost system to capture spatial vehicle headway data and process the raw data by filtering outliers using a novel filtering process. Multiple sensors and modules are integrated to form the system. The sensors used are compact, lightweight, low-cost and have low power consumption. A single beam 1-Dimensional Light Detection and Ranging (LIDAR) was used for capturing the space headway data, a Global Positioning System (GPS) to map each data point with a timestamp and position and also a camera to capture video data with an overlay of date, time, distance and speed in real-time. The filtering technique utilizes the Autoregressive Integrated Moving Average (ARIMA) prediction modeling and mean-filtering. The data captured is stored in a Raspberry Pi module. The data is later processed by using the filtering technique to obtain the least outliers. The overall system has enabled to capture spatial headway data and speed of the vehicle at a very low cost and the data obtained can be used for car-following model analysis and speed-density analysis.Comment: 16 pages, 9 figures, and 2 table

FEELnc : a tool for long non-coding RNA annotation and its application to the dog transcriptome

Whole transcriptome sequencing (RNA-seq) has become a standard for cataloguing and monitoring RNA populations. One of the main bottlenecks, however, is to correctly identify the different classes of RNAs among the plethora of reconstructed transcripts, particularly those that will be translated (mRNAs) from the class of long non-coding RNAs (lncRNAs). Here, we present FEELnc (FlExible Extraction of LncRNAs), an alignment-free program that accurately annotates lncRNAs based on a Random Forest model trained with general features such as multi k-mer frequencies and relaxed open reading frames. Benchmarking versus five state-of-the-art tools shows that FEELnc achieves similar or better classification performance on GENCODE and NONCODE data sets. The program also provides specific modules that enable the user to fine-tune classification accuracy, to formalize the annotation of lncRNA classes and to identify lncRNAs even in the absence of a training set of non-coding RNAs. We used FEELnc on a real data set comprising 20 canine RNA-seq samples produced by the European LUPA consortium to substantially expand the canine genome annotation to include 10 374 novel lncRNAs and 58 640 mRNA transcripts. FEELnc moves beyond conventional coding potential classifiers by providing a standardized and complete solution for annotating lncRNAs and is freely available at https://github.com/tderrien/FEELnc.Peer reviewe

Primary cilia, ciliogenesis and the actin cytoskeleton: a little less resorption, a little more actin please

Primary cilia are microtubule-based organelles that extend from the apical surface of most mammalian cells, forming when the basal body (derived from the mother centriole) docks at the apical cell membrane. They act as universal cellular “antennae” in vertebrates that receive and integrate mechanical and chemical signals from the extracellular environment, serving diverse roles in chemo-, mechano- and photo-sensation that control developmental signaling, cell polarity and cell proliferation. Mutations in ciliary genes cause a major group of inherited developmental disorders called ciliopathies. There are very few preventative treatments or new therapeutic interventions that modify disease progression or the long-term outlook of patients with these conditions. Recent work has identified at least four distinct but interrelated cellular processes that regulate cilia formation and maintenance, comprising the cell cycle, cellular proteostasis, signaling pathways and structural influences of the actin cytoskeleton. The actin cytoskeleton is composed of microfilaments that are formed from filamentous (F) polymers of globular G-actin subunits. Actin filaments are organized into bundles and networks, and are attached to the cell membrane, by diverse cross-linking proteins. During cell migration, actin filament bundles form either radially at the leading edge or as axial stress fibers. Early studies demonstrated that loss-of-function mutations in ciliopathy genes increased stress fiber formation and impaired ciliogenesis whereas pharmacological inhibition of actin polymerization promoted ciliogenesis. These studies suggest that polymerization of the actin cytoskeleton, F-actin branching and the formation of stress fibers all inhibit primary cilium formation, whereas depolymerization or depletion of actin enhance ciliogenesis. Here, we review the mechanistic basis for these effects on ciliogenesis, which comprise several cellular processes acting in concert at different timescales. Actin polymerization is both a physical barrier to both cilia-targeted vesicle transport and to the membrane remodeling required for ciliogenesis. In contrast, actin may cause cilia loss by localizing disassembly factors at the ciliary base, and F-actin branching may itself activate the YAP/TAZ pathway to promote cilia disassembly. The fundamental role of actin polymerization in the control of ciliogenesis may present potential new targets for disease-modifying therapeutic approaches in treating ciliopathies

MIA3 Splice Defect in Cane Corso Dogs with Dental-Skeletal-Retinal Anomaly (DSRA)

We investigated a hereditary syndrome in Cane Corso dogs. Affected dogs developed dental-skeletal-retinal anomaly (DSRA), clinically characterized by brittle, discolored, translucent teeth, disproportionate growth and progressive retinal degeneration resulting in vision loss. Combined linkage and homozygosity mapping delineated a 5.8 Mb critical interval. The comparison of whole genome sequence data of an affected dog to 789 control genomes revealed a private homozygous splice region variant in the critical interval. It affected the MIA3 gene encoding the MIA SH3 domain ER export factor 3, which has an essential role in the export of collagen and other secreted proteins. The identified variant, XM_005640835.3:c.3822+3_3822+4del, leads to skipping of two exons from the wild type transcript, XM_005640835.3:r.3712_3822del. Genotypes at the variant were consistent with monogenic autosomal recessive mode of inheritance in a complete family and showed perfect genotype-phenotype association in 18 affected and 22 unaffected Cane Corso dogs. MIA3 variants had previously been shown to cause related phenotypes in humans and mice. Our data in dogs together with the existing functional knowledge of MIA3 variants in other mammalian species suggest the MIA3 splice defect and a near complete loss of gene function as causative molecular pathomechanism for the DSRA phenotype in the investigated dogs

Marta Czok ARCHĪVUM VR edition: in collaboration with Anise Gallery and AVR London, curated by Jacek Ludwig Scarso

After the recent passing of Marta Czok in February 2025, Fondazione Marta Czok presents the first exhibition following her death, featuring the international premiere of a VR collaboration with Anise Gallery and AVR London. Responding to the 2025 Architecture Biennale, this selection of works features the cityscape as key symbol in Czok’s social and political commentary and uses virtual reality to bring this to life, by reimagining Czok’s 1989 triptych ‘The Other Half/ L’Altra Metà’. Curated by Jacek Ludwig Scarso, with the patronage of Presidenza Commissione Cultura of the Italian Parliament and of the Polish Embassy in Rome