Bridging GPS Outages Using Spectral Fusion and Neural Network Models in Support of Multibeam Hydrography

In classical hydrographic surveying, the use of GPS is limited to providing horizontal control for survey vessels. More recently, an alternative practice has evolved, which determines depth values relative to a geodetic datum and then relate them to tidal datums through a series of vertical datum transformations. Although it has a number of advantages over classical hydrographic surveying, this practice requires accurate 3D positioning information. Unfortunately, accurate 3D positioning solution may not always be available as a result of communication link problems, GPS outages, or unsuccessful fixing for the ambiguity parameters. This paper examines the use of wavelet analysis to spectrally combine the GPS/INS height data series and the heave signal to bridge the height data gaps. In addition, a neural network-based model is developed to precisely predict the horizontal component of the survey vessel.En los levantamientos hidrográficos clásicos, el uso del GPS está limitado al suministro de control horizontal para los buques hidrográficos. Más recientemente, se ha desarrollado una práctica alterna-tiva, que determina los valores de la profundidad relativos a un datum geodésico y los relaciona pos-teriormente con los datums de mareas a través de una serie de transformaciones del datum vertical. Aunque tiene una serie de ventajas con respecto a los levantamientos hidrográficos clásicos, esta práctica requiere una información precisa del posicionamiento en 3D. Desgraciadamente, puede que una solución de posicionamiento preciso en 3D no esté siempre disponible como resultado de los problemas de enlaces de datos, los cortes GPS, o un ajuste infructuoso de parámetros de ambigüedad. Este artículo examina el uso de un análisis de ondas pequeñas para combinar espectralmente la serie de datos de altura GPS/INS y la señal de oleaje para superar las deficiencias de datos de alturas. Además, se ha desarrollado un modelo basado en la red neural para predecir con precisión la compo-nente horizontal del buque hidrográfico.Dans les levés hydrographiques classiques, l‘utilisation du GPS est limitée à la fourniture d‘un contrôle horizontal pour les bâtiments hydrographiques. Plus récemment, une autre pratique est ap-parue et celle-ci détermine les valeurs de profondeur par rapport à un système géodésique puis les rapporte au niveau de référence des marées par le biais d‘une série de transformations du système géodésique vertical. Bien que ceci offre un certain nombre d‘avantages par rapport aux levés hydro-graphiques classiques, cette pratique nécessite des informations exactes sur la détermination de la position en 3D. Malheureusement, une solution exacte de détermination de la position en 3D n‘est pas toujours disponible à cause de problèmes de liaison en matière de communications, de défaillan-ces GPS, ou de réparation infructueuse des paramètres d‘ambiguïté. Le présent article examine l‘uti-lisation d‘une analyse des ondelettes pour combiner de manière spectrale les séries de données de hauteur GPS/INS et le signal de pilonnement afin de combler les lacunes en données de hauteur. En outre, un modèle inspiré d‘un réseau neuronal est en cours de développement en vue d‘une prédic-tion précise de la composante horizontale du bâtiment hydrographique

Is Real-time Phishing Eliminated with FIDO? Social Engineering Downgrade Attacks against FIDO Protocols

FIDO’s U2F is a web-authentication mechanism designed to mitigate real-time phishing—an attack that undermines multi-factor authentication by allowing an attacker to relay second-factor one-time tokens from the victim user to the legitimate website in real-time. A U2F dongle is simple to use, and is designed to restrain users from using it incorrectly. We show that social engineering attacks allow an adversary to downgrade FIDO’s U2F to alternative authentication mechanisms. Websites allow such alternatives to handle dongle malfunction or loss. All FIDO-supporting websites in Alexa’s top 100 allow choosing alternatives to FIDO, and are thus potentially vulnerable to real-time phishing attacks. We crafted a phishing website that mimics Google login’s page and implements a FIDO-downgrade attack. We then ran a carefully-designed user study to test the effect on users. We found that, when using FIDO as their second authentication factor, 55% of participants fell for real-time phishing, and another 35% would potentially be susceptible to the attack in practice

Global economic burden of unmet surgical need for appendicitis

Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was USD 92 492 million using approach 1 and USD 73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was USD 95 004 million using approach 1 and USD 75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially.publishedVersio

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Methylation in MIRLET7A3 Gene Induces the Expression of IGF-II and Its mRNA Binding Proteins IGF2BP-2 and 3 in Hepatocellular Carcinoma

miR-let-7a is a tumor suppressor miRNA with reduced expression in most cancers. Methylation of MIRLET7A3 gene was reported to be the cause of this suppression in several cancers; however, it was not explicitly investigated in hepatocellular carcinoma (HCC). We aimed at investigating miR-let-7a expression and molecular mode in HCC, identifying drug-targetable networks, which might be affected by its abundance. Our results illustrated a significant repression of miR-let-7a, which correlated with hypermethylation of its gene of origin MIRLRT7A3. This was further supported by the induction of miR-let-7a expression upon treatment of HCC cells with a DNA-methyltransferase inhibitor. Using a computational approach, insulin-like growth factor (IGF)-II and IGF-2 mRNA binding proteins (IGF2BP)-2/-3 were identified as potential targets for miR-let-7a that was further confirmed experimentally. Indeed, miR-let-7a mimics diminished IGF-II as well as IGF2BP-2/-3 expression. Direct binding of miR-let-7a to each respective transcript was confirmed using a luciferase reporter assay. In conclusion, this study suggests that DNA hypermethylation leads to epigenetic repression of miR-let-7a in HCC cells, which induces the oncogenic IGF-signaling pathway

Is Real-time Phishing Eliminated with FIDO? Social Engineering Downgrade Attacks against FIDO Protocols

FIDO's U2F is a web-authentication mechanism designed to mitigate real-time phishing-an attack that undermines multi-factor authentication by allowing an attacker to relay second-factor one-time tokens from the victim user to the legitimate website in real-time. A U2F dongle is simple to use, and is designed to restrain users from using it incorrectly. We show that social engineering attacks allow an adversary to downgrade FIDO's U2F to alternative authentication mechanisms. Websites allow such alternatives to handle dongle malfunction or loss. All FIDO-supporting websites in Alexa's top 100 allow choosing alternatives to FIDO, and are thus potentially vulnerable to real-time phishing attacks. We crafted a phishing website that mimics Google login's page and implements a FIDO-downgrade attack. We then ran a carefullydesigned user study to test the effect on users. We found that, when using FIDO as their second authentication factor, 55% of participants fell for real-time phishing, and another 35% would potentially be susceptible to the attack in practice