Analysis of Selected Physicochemical Parameters of Soils Used for Cultivation of Garlic (Allium sativum L.)

Assessment of some selected physicochemical parameters in soil samples collected from four agricultural areas of East Gojjam Zone (Debre Markos, Dejen, Bichena and Debre Werk), Ethiopia was studied. The soil characterization was carried out for parameters like moisture content (MC), pH, electrical conductivity (EC), organic carbon (OC), organic matter (OM), cation exchange capacity (CEC), potassium, sodium, calcium and magnesium. Na and K in the soil samples were analyzed using flame photometer, Ca and Mg were analyzed by atomic absorption spectrophotometer while conventional analytical methods were employed for the determination of the rest of the physicochemical parameters. The results obtained revealed that the concentrations of physicochemical parameters in the soil samples were in the range of; 7.35-11.01% for MC, 6.53-7.64 for pH, 0.09-0.34 mS/cm for EC, 1.25-3.44% for OC, 2.16-5.93% for OM, 30.75-41.83 cmol/kg for CEC, 845-1014 mg/kg for Na, 1980-6065 mg/kg for K, 952–2118 mg/kg for Ca and1751–4288 mg/kg for Mg. pH was found to vary from neutrality to slightly alkaline. The values of EC indicated that all samples of the soils are non-saline. Statistical test of significance using ANOVA revealed that there were no significant differences (P>0.05) between the values of physicochemical parameters in the soil samples obtained from all the sampling sites. Correlation analysis was also employed to examine the relationship between the various parameters in the soil samples. The soil studied can be considered as good sources of essential nutrients and this information will help farmers to solve the problems related to soil nutrients, amount of which fertilizers to be used to increase the yield of crops

Intestinal parasites among HIV/AIDS patients attending University of Gondar Hospital, northwest Ethiopia

Background: Opportunistic intestinal parasitic infections are the major public health problem among human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients. In the absence of anti-retroviral therapy (ART), HIV/AIDS patients in developing countries such as Ethiopia continue to suffer from the consequences of intestinal parasites. This study aimed to determine the prevalence of opportunistic and other intestinal parasites among on-ART HIV/AIDS patients.Methods: A comparative cross-sectional study was conducted from December 2015 to January2016 among pre-ART and on-ART adult HIV/AIDS patients at University of Gondar Hospital, northwest Ethiopia. A pre-tested structured questionnaire was used to collect data on socio-demographic and associated risk factors. Systematic random sampling was used to select the study participants. Stool samples were collected and processed using a direct, wet-mount, formol-ether concentration technique and modified Ziehl-Neelsen staining technique. The CD4 counts were estimated by using the BD FACS Count system. Data were entered and analyzed using SPSS 20 software.Results: A total of 150 study participants (48ARTnaïve and102 on ART) were included in the study. The overall prevalence of intestinal parasitic infections was 45.3% – 25.3% in pre-ART patients and 20% in on-ART patients. Two thirds (8/12) of opportunistic parasitic infections were found in the ART-naïve patients and significantly associated with CD4 counts <200 cells/mm3. Those who have no toilet [AOR=5.21, 95% CI: 1.82, 16.03], source of water from stream [AOR = 2.8; 95% CI: 1.05, 7.72], who have diarrhea [AOR = 11.38; 95% CI: 4.69, 15.61], WHO stage III [AOR =5.3; 95% CI: 2.47, 11.56] and ART status [AOR = 4.2; 95% CI: 2.02, 8.77] were significantly associated with the prevalence of intestinal parasites.Conclusions: The prevalence of intestinal parasites was found to be higher in ART-naïve than on-ART patients. High proportions of intestinal parasites were associated with lower CD4 counts, ART naïve, diarrhea, WHO stage III, absence of toilet and source of water from stream. Therefore, public health measures and adherence to ART for ART naïve should be strengthened to improve the quality of life of these patients. [Ethiop.J. Health Dev. 2019; 33(2):65-72]Key words: Opportunistic intestinal parasites, CD4 T-cells, Anti-retroviral therapy, diarrhea, Gonda

Women's Independent Household Decision Making Power and its influence on their Autonomy in relation to Child Vaccinations: a mixed-method study among Women of Reproductive Age in Northwest Ethiopia

AbstractBackground: The importance of women’s empowerment in influencing health outcomes has received attention globally, but there is limited information in Ethiopia on the relationship between women's household decision making power and the autonomy of decision making in relation to child vaccinations.Aim: The study aimed to assess the role of women's household decision making power on their autonomy in relation to child vaccinations.Methods: A community based mixed method study design was conducted among women who had 12–23-month-old children in Wogera district, Ethiopia. The sample size was determined using a single population proportion formula for the quantitative aspect of the study and the data collection for the qualitative study continued until saturation. The quantitative data was collected using a piloted questionnaire. SPSS software was used for quantitative data analyses. X2-square test was conducted to explore the association between women's household decision making power and their autonomy in relation to decision making around child vaccinations. Framework analysis was employed to analyse qualitative data using open code software.Results: A total of 584 women participated in the quantitative study and 13 In-depth interviews (IDI) with 13 key informants (KII)were conducted for the qualitative study. Majority, 88.2% (95% CI: 85.7, 90.6) of the respondents have autonomy to vaccinate children. This study showed that nearly two-thirds, 61.6% of the women had household decision making power. Respondents of the qualitative study noted that women had low household decision making power. Women's household decision making power is associated with women's autonomy to vaccinate children (x2=92.775a, df=1, P<0.001).Conclusions: The overall level of women’s household decision making power was relatively low compared to EDHS reports whereas women's autonomy to chid vaccination was high. There was a strong relationship between women’s household decision making power and their autonomy in relation to child vaccinations. It is therefore important to implement activities, for example, provision of behavioural change communication (BCC) in the community, that can improve women’s household decision making power which in turn will influence child vaccination coverage. [Ethiop. J. Health Dev. 2021; 35(SI-3):86-97]Key words: Women, Household decision making power, Women's autonomy, Vaccinatio

Full immunization coverage and its determinants among children aged 12-23 months in Wogera district, Northwest Ethiopia

AbstractBackground: Immunization is considered one of the most affordable health initiatives for children. Though there is good progress in Ethiopia, the amount of fully vaccinated children, is still below the target. Possible challenges include women having home visits and men’s’ involvement in vaccination uptake. Therefore, this study aimed to determine full immunization coverage and its determinants among children aged 12- 23 months in Wogera districts, Northwest Ethiopia.Aim: This study aimed to determine the full immunization coverage and its determinants among children aged 12-23 months, and to assess the level of immunization coverage and its determinants in Wogera districts, Northwest Ethiopia.Methods: A community-based cross-sectional study was conducted in Wogera district from May 28-June 25/2020. Cluster sampling method was used to recruit 598 study participants. Interviewer administered questionnaire was used to collect data. A bivariable and multivariable logistic regression analysis was done to identify factors associated with full immunization. Odds ratios with 95% Confidence intervals were used to determine significant variables.Results: A total of 584 mothers who had children aged 12-23 months participated in this study. The full immunization coverage was 76.5% (95%CI 73.2-79.8). Mother age >40 years (AOR=7.37, 95% CI: 1.65, 32); mothers who initiate vaccine uptake(woman empowerment) (AOR=1.57, 95% CI: 1.13-2.39); mothers who had 1-3 ANC visit (AOR=2.51, 95% CI:1.14, 5.52), and 4+ ANC follow up (AOR=2.73,95% CI: 1.26, 5.91); r health extension worker's home visit during the first weeks of postpartum period (AOR=1.76,95% CI:1.10, 2.84), and males involved in child immunization (AOR=3.27, 95% CI:1.84, 5.81) was positively associated with being fully vaccinated , however, birth order of 6 and above (AOR=0.35, 95% CI: 0.14, 0.86) was negatively associated with being fully vaccinated.Conclusion: In this study, the full immunization coverage is found to be suboptimal, and it is far from the expected national target coverage. Maternal health care uptake; women empowerment; home visits by HEW during the first week of the postpartum period and male involvement in child immunization were found to be predictors of being fully vaccinated. [Ethiop. J. Health Dev. 2021; 35(SI-3):16-27]Keywords: Full immunization, Children12-23 months, Northwest Ethiopia, Male involvemen

Cross-Correlation of Soil Moisture and Stone Content and Their Spatial Pattern Across the Different Slope Aspects and Soil Depth

The analysis of the spatial interrelationship between soil properties and slope aspect is vital for understanding the range of influence on soil depth, moisture, and stone content distribution. This study aimed to investigate the spatial interrelationship of topsoil moisture and stone content in different slope aspects and soil depth. The 53.7 km2 watershed was divided into a 500m by 500m grid using ArcGIS and 230 soil samples were collected. In each sampling point, the soil was taken at three soil depth classes (0–25cm, 25–60cm, and 60–100cm) using a cylindrical auger, then soil samples were tested to determine the percentage of topsoil moisture, and stone content. The spatial interrelationship between aspect, soil depth, topsoil moisture, and stone content was analyzed using the R and GS+ software. The study had shown non-significant effects of aspect on topsoil moisture, stone content, and soil depth. However, topsoil moisture tends to be higher on the north-facing slope, while stone content tends to be higher on the southeast-facing slope. The analysis of Local Moran’s I revealed that topsoil moisture, stone content, and soil depth were significantly autocorrelated. The cross-semivariogram analysis of soil depth with topsoil stone content depicted a negative spatial correlation. The experimental cross-semivariogram of soil depth versus topsoil moisture was positively fitted to the exponential function, whereas soil depth with topsoil stone content was best fitted to the Gaussian model. Overall, soil depth is the more influential factor than the slope aspect regarding topsoil moisture depletion and stone content distribution in the study watershed

Prevalence and Associated Factors of Violence against Hospital Staff at Amanuel Mental Specialized Hospital in Addis Ababa, Ethiopia.

Background. Violence at the workplace has become an alarming phenomenon worldwide. The real size of the problem is largely unknown and recent information shows that the current knowledge is only the tip of the iceberg. The enormous cost of violence at the workplace for person and community at large is becoming more apparent. It could be physical, sexual, and verbal in nature and could be actual or threatened. Objectives. To access prevalence and associated factors of violence against hospital staff at Amanuel Mental Specialized Hospital Addis Ababa, Ethiopia. Methods. An institution based cross-sectional study was employed in 2017. The data were collected using Workplace Violence in the Health Sector Country Case Study Questionnaire from 496 participants. Participants had been selected using simple random sampling technique and data were collected using a self-administered structured questionnaire. The collected data were entered into Epi-data version 3.1, and SPSS version 21 was used for Analysis. Binary logistic regression was fitted to identify factors associated with the outcome variable. Result. From 496 staff intended to have participated in this study, complete data were obtained from 435, making a response rate of 87.7%. This research showed high prevalence of violence and we have got that staff had been exposed to physical violence 36.8%, verbal violence 62.1%, and sexual violence 21.8 % over the past year, respectively. Age, sex, and contact with the patient were statistically significant variables (p < 0.05). Conclusion and Recommendation. According to this study, majority of AMSH staff were violated by the patient they care.Peer Reviewe

Prevalence of medication non-adherence and associated factors among diabetic patients in a tertiary hospital at Debre Markos, Northwest Ethiopia

BACKGROUND: Non-adherence to prescribed medications is possibly the most common reason for poor treatment outcomes among people with diabetes although its rate is highly variable. Data on the magnitude of medication non-adherence and associated factors are scarce in the study area. This study aimed to assess the rate of non-adherence and associated factors among diabetic patients at Debre Markos Comprehensive Specialized Hospital.METHODS: A cross-sectional study was conducted from June 17 to July 17, 2021. Study participants were selected using a simple random sampling technique. Data were collected with a pre-tested structured questionnaire and entered into SPSS version 25. Logistic regression was utilized to determine predictors of medication non-adherence at a significance level of ≤ 0.05.RESULTS: A total of 176 study participants were enrolled in the study. About 59% of the study participants had type-2 diabetes mellitus. The prevalence of non-adherence to anti-diabetic medications was found to be 41.5%. Male sex, rural residence, being divorced, being merchant, self- or family-borne medical cost, and presence of comorbidities were significantly associated with increased rate of non-adherence to anti-diabetic medications.CONCLUSION: The prevalence of non-adherence to medications among diabetic patients is significantly high in the study area. Public health measures should be strengthened to decrease nonadherence among diabetic patients

Effect of antenatal care on low birth weight: a systematic review and meta-analysis in Africa, 2022

BackgroundRisk identification, as well as the prevention and management of diseases associated with pregnancy or other conditions that may occur concurrently, is the essential component of ANC.MethodThe observational follow-up and cross-sectional studies on the effect of antenatal care on low birth weight in Africa were conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Five computerized bibliographic databases: Google Scholar, PubMed, Scopus, Cochrane Library, and Hinari Direct were searched for published studies written in English till May 2022. The risk of bias assessment tools developed by the Joanna Briggs Institute for cross-sectional and observational follow-up research was used, and the caliber of each included study was assessed. Seven papers were included, with a total of 66,690 children participating in the study.ResultsSeven studies met the selection criteria. Prenatal care and low birth weight were linked in four of the seven studies included in the review. The pooled odd ratio for low birth weight in the random-effects model was 0.46 (95% CI: 0.39, 0.53). The pooled odds ratio for low birth weight was 0.21 (95% CI: 0.19, 0.22) and 0.21 (95% CI: 0.19, 0.22), respectively, among pregnant women who had no antenatal care follow-up and those who had antenatal care follow up.ConclusionWomen who attended at least one antenatal care appointment were more likely than their counterparts to have a baby of normal weight. Interventions to reduce low birth weight in Africa should focus on providing adequate antenatal care and quality healthcare services to women with low socioeconomic status

Extracellular vesicles: immunomodulation, diagnosis, and promising therapeutic roles for rheumatoid arthritis

Extracellular vesicles (EV) can be produced as part of pathology and physiology with increased amounts in pathological conditions. EVs can carry and transfer cargo such as proteins, nucleic acids, and lipids to target cells and mediate intercellular communication resulting in modulation of gene expression, signaling pathways, and phenotype of recipient cells. EVs greatly influence the extracellular environment and the immune response. Their immunomodulatory properties are crucial in rheumatoid arthritis (RA), a condition marked by dysregulated immune response. EVs can modulate the functions of innate and adaptive immune cells in RA pathogenesis. Differentially expressed EV-associated molecules in RA, such as microRNAs (miRNAs), long-noncoding RNAs (lncRNAs), messenger RNAs (mRNAs) and proteins are promising markers to diagnose the disease. miRNA, lncRNA, and circular RNA (circRNA) cargos in EV regulate inflammation and the pathogenic functions of RA fibroblast-like synoviocytes (RA-FLS). Downregulated molecules in RA tissue and drugs can be encapsulated in EVs for RA therapy. This review provides an updated overview of EVs’ immunomodulatory, diagnostic, and therapeutic roles, particularly emphasizing mesenchymal stem cell-derived EVs (MSC-EVs)

A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents

Diabetes mellitus (DM) has emerged as an international health epidemic due to its rapid rise in prevalence. Consequently, scientists and or researchers will continue to find novel, safe, effective, and affordable anti-diabetic medications. The goal of this review is to provide a thorough overview of the role that lifestyle changes play in managing diabetes, as well as the standard medications that are currently being used to treat the condition and the most recent advancements in the development of novel medical treatments that may be used as future interventions for the disease. A literature search was conducted using research databases such as PubMed, Web of Science, Scopus, ScienceDirect, Wiley Online Library, Google Scholar, etc. Data were then abstracted from these publications using words or Phrases like “pathophysiology of diabetes”, “Signe and symptoms of diabetes”, “types of diabetes”, “major risk factors and complication of diabetes”, “diagnosis of diabetes”, “lifestyle modification for diabetes”, “current antidiabetic agents”, and “novel drugs and targets for diabetes management” that were published in English and had a strong scientific foundation. Special emphasis was given to the importance of lifestyle modification, as well as current, novel, and emerging/promising drugs and targets helpful for the management of both T1DM and T2DM