Contractor-Renormalization approach to frustrated magnets in magnetic field

We propose to use the Contractor Renormalization (CORE) technique in order to derive effective models for quantum magnets in a magnetic field. CORE is a powerful non-perturbative technique that can reduce the complexity of a given microscopic model by focusing on the low-energy part. We provide a detailed analysis of frustrated spin ladders which have been widely studied in the past: in particular, we discuss how to choose the building block and emphasize the use of their reduced density matrix. With a good choice of basis, CORE is able to reproduce the existence or not of magnetization plateaux in the whole phase diagram contrary to usual perturbation theory. We also address the issue of plateau formation in two-dimensional bilayers and point out the analogy between non-frustrated strongly anisotropic models and frustrated SU(2) ones.Comment: 13 pages, 20 figures; published version with minor change

Effective Theory of Magnetization Plateaux in the Shastry-Sutherland Lattice

We use the non-perturbative Contractor-Renormalization method (CORE) in order to derive an effective model for triplet excitations on the Shastry-Sutherland lattice. For strong enough magnetic fields, various magnetization plateaux are observed, e.g. at 1/8, 1/4, 1/3 of the saturation, as found experimentally in a related compound. Moreover, other stable plateaux are found at 1/9, 1/6 or 2/9. We give a critical review of previous works and try to resolve some apparent inconsistencies between various theoretical approaches.Comment: published version with minor change

Natriuretic peptide receptor-C is up-regulated in the intima of advanced carotid artery atherosclerosis

OBJECTIVE: Natriuretic peptide receptor-C (NPR-C/NPR-3) is a cell surface protein involved in vascular remodelling that is up-regulated in atherosclerosis. NPR-C expression has not been well characterized in human carotid artery occlusive lesions. We hypothesized that NPR-C expression correlates with intimal features of vulnerable atherosclerotic carotid artery plaque. METHODS: To test this hypothesis, we evaluated NPR-C expression by immunohistochemistry (IHC) in carotid endarterectomy (CEA) specimens isolated from 18 patients. The grade, location, and co-localization of NPR-C in CEA specimens were evaluated using two tissue analysis techniques. RESULTS: Relative to minimally diseased CEA specimens, we observed avid NPR-C tissue staining in the intima of maximally diseased CEA specimens (65%; p=0.06). Specifically, maximally diseased CEA specimens demonstrated increased NPR-C expression in the superficial intima (61%, p=0.17), and deep intima (138% increase; p=0.05). In the superficial intima, NPR-C expression significantly co-localized with vascular smooth muscle cells (VSMCs) and macrophages. The intensity of NPR-C expression was also higher in the superficial intima plaque shoulder and cap regions, and significantly correlated with atheroma and fibroatheroma vulnerable plaque regions (β=1.04, 95% CI=0.46, 1.64). CONCLUSION: These findings demonstrate significant NPR-C expression in the intima of advanced carotid artery plaques. Furthermore, NPR-C expression was higher in vulnerable carotid plaque intimal regions, and correlate with features of advanced disease. Our findings suggest that NPR-C may serve as a potential biomarker for carotid plaque vulnerability and progression, in patients with advanced carotid artery occlusive disease

Precarious but Happy? Young Researchers in Media Education

Die Prekarisierung der Beschäftigungsverhältnisse von Qualifikanden/-innen rücken zunehmend in das Interesse bildungspolitischer und öffentlicher Diskussionen. Selbst der Ausdruck ‹wissenschaftlicher Nachwuchs› steht in der Kritik. Der vorliegende Beitrag verortet die Situation der Medienpädagogik im deutschsprachigen Raum in dieser Debatte. Drei ausgewählte Schwerpunkte werden dafür in den Blick genommen: (1.) die Rolle von Wissenschaftlern/-innen in Qualifizierungsphasen im aktuellen Wissenschaftssystem, (2.) die Situation in der Disziplin der Erziehungswissenschaft sowie (3.) der Prozess der Prekarisierung in der Wissenschaft. Die Frage, inwiefern die markierten Veränderungen des Wissenschaftssystems und damit zusammenhängende Herausforderungen auch Medienpädagogen/-innen im deutschsprachigen Raum betreffen, wird auf Basis einer online durchgeführten Fragebogen-Untersuchung mit 76 Teilnehmern/-innen diskutiert. In exemplarischer Betrachtung der Fragenkomplexe (1) Zufriedenheit mit Arbeits- und Beschäftigungsverhältnissen, (2) Betreuungssituation sowie (3) Work-Life-Balance zeigt sich einerseits eine allgemeine Zufriedenheit hinsichtlich der Möglichkeiten des selbstbestimmten Arbeitens, des sozialen Arbeitsumfelds sowie mit der Betreuung der eigenen Qualifikationsarbeit. Anderseits werden auch in der Medienpädagogik Probleme deutlich, die den wissenschaftlichen Nachwuchs disziplinübergreifend betreffen: Die mangelnde berufliche Sicherheit und Planbarkeit der Karriere zählen zu den grössten problematischen Aspekten für Wissenschaftler/-innen in Qualifizierungsphasen.The precarization of emerging researchers’ job positions is increasingly discussed in public debates on education policy. Even the term ‹wissenschaftlicher Nachwuchs› is being criticised. This paper examines the situation within academic media education in German-speaking countries. The selected focal points are: (1.) the role of scholars currently in qualification processes, (2.) the situation within educational science and (3.) the process of precarization in academia. To answer the question for the situation for qualifying scholars in media education in German-speaking countries, results from an online questionnaire (n=76) are presented and discussed. The authors focus on the following topics (1) satisfaction with current employment situations, (2) supervision of the qualifying projects and (3) work-life balance. On the one hand, findings show general contentment with the opportunity to work in a self-determined way, with social aspects of the working environment, and with supervisors. On the other hand, general problems also arise in the field of media education: A lack of planning reliability for academic careers is among the most problematic aspects for scholars in qualification processes

Magnetization plateaux in an extended Shastry-Sutherland model

We study an extended two-dimensional Shastry-Sutherland model in a magnetic field where besides the usual Heisenberg exchanges of the Shastry-Sutherland model two additional SU(2) invariant couplings are included. Perturbative continous unitary transformations are used to determine the leading order effects of the additional couplings on the pure hopping and on the long-range interactions between the triplons which are the most relevant terms for small magnetization. We then compare the energy of various magnetization plateaux in the classical limit and we discuss the implications for the two-dimensional quantum magnet SrCu$_2$(BO$_3$)$_2$.Comment: 8 pages, Proceedings of the HFM2008 Conferenc

Noninvasive imaging of focal atherosclerotic lesions using fluorescence molecular tomography

Insights into the etiology of stroke and myocardial infarction suggest that rupture of unstable atherosclerotic plaque is the precipitating event. Clinicians lack tools to detect lesion instability early enough to intervene, and are often left to manage patients empirically, or worse, after plaque rupture. Noninvasive imaging of the molecular events signaling prerupture plaque progression has the potential to reduce the morbidity and mortality associated with myocardial infarction and stroke by allowing early intervention. Here, we demonstrate proof-of-principle in vivo molecular imaging of C-type natriuretic peptide receptor in focal atherosclerotic lesions in the femoral arteries of New Zealand white rabbits using a custom built fiber-based, fluorescence molecular tomography (FMT) system. Longitudinal imaging showed changes in the fluorescence signal intensity as the plaque progressed in the air-desiccated vessel compared to the uninjured vessel, which was validated by ex vivo tissue studies. In summary, we demonstrate the potential of FMT for noninvasive detection of molecular events leading to unstable lesions heralding plaque rupture

Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size

Calcium-independent phospholipase A(2)γ (iPLA(2)γ) is a mitochondrial enzyme that produces lipid second messengers that facilitate opening of the mitochondrial permeability transition pore (mPTP) and contribute to the production of oxidized fatty acids in myocardium. To specifically identify the roles of iPLA(2)γ in cardiac myocytes, we generated cardiac myocyte-specific iPLA(2)γ knock-out (CMiPLA(2)γKO) mice by removing the exon encoding the active site serine (Ser-477). Hearts of CMiPLA(2)γKO mice exhibited normal hemodynamic function, glycerophospholipid molecular species composition, and normal rates of mitochondrial respiration and ATP production. In contrast, CMiPLA(2)γKO mice demonstrated attenuated Ca(2+)-induced mPTP opening that could be rapidly restored by the addition of palmitate and substantially reduced production of oxidized polyunsaturated fatty acids (PUFAs). Furthermore, myocardial ischemia/reperfusion (I/R) in CMiPLA(2)γKO mice (30 min of ischemia followed by 30 min of reperfusion in vivo) dramatically decreased oxidized fatty acid production in the ischemic border zones. Moreover, CMiPLA(2)γKO mice subjected to 30 min of ischemia followed by 24 h of reperfusion in vivo developed substantially less cardiac necrosis in the area-at-risk in comparison with their WT littermates. Furthermore, we found that membrane depolarization in murine heart mitochondria was sensitized to Ca(2+) by the presence of oxidized PUFAs. Because mitochondrial membrane depolarization and calcium are known to activate iPLA(2)γ, these results are consistent with salvage of myocardium after I/R by iPLA(2)γ loss of function through decreasing mPTP opening, diminishing production of proinflammatory oxidized fatty acids, and attenuating the deleterious effects of abrupt increases in calcium ion on membrane potential during reperfusion

Coulomb parameters and photoemission for the molecular metal TTF-TCNQ

We employ density-functional theory to calculate realistic parameters for an extended Hubbard model of the molecular metal TTF-TCNQ. Considering both intra- and intermolecular screening in the crystal, we find significant longer-range Coulomb interactions along the molecular stacks, as well as inter-stack coupling. We show that the long-range Coulomb term of the extended Hubbard model leads to a broadening of the spectral density, likely resolving the problems with the interpretation of photoemission experiments using a simple Hubbard model only.Comment: 4 pages, 2 figure