Drugst.One — a plug-and-play solution for online systems medicine and network-based drug repurposing

In recent decades, the de v elopment of ne w drugs has become increasingly e xpensiv e and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools ha v e emerged to identify potential drug repurposing candidates. Ho w e v er, these tools often require complex installation and lack intuitive visual network mining capabilities. To tac kle these c hallenges, we introduce Drugst.One, a platform that assists specialized computational medicine tools in becoming user-friendly, web-based utilities for drug repurposing . W ith just three lines of code, Drugst.One turns any systems biology software into an interactive web tool for modeling and analyzing complex protein-drug-disease networks. Demonstrating its broad adapt abilit y, Drugst.One has been successfully integrated with 21 computational systems medicine tools. Available at https://dr ugst.one , Dr ugst.One has significant potential for streamlining the drug disco v ery process, allowing researchers to focus on essential aspects of pharmaceutical treatment research.REPO-TRIAL: this project has received funding from the European Union’s Horizon 2020 research and innovation programme [777111]; this publication reflects only the authors’ view and the European Commission is not responsible for any use that may be made of the information it contains; RePo4EU: this project is funded by the European Union [101057619]; views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or European Health and Digital Executive Agency (HADEA). Neither the European Union nor the granting authority can be held responsible for them; Swiss State Secretariat for Education, Research and Innovation (SERI) [22.00115]; German Federal Ministry of Education and Research (BMBF) within the framework of ‘CLINSPECT-M/-2’ [F031L0214A, 161L0214A, 16LW0243K]; Technical University Munich – Institute for Advanced Study, funded by the German Excellence Initiative; Intramural Research Programs (IRPs) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [422216132]; J.B. was partially funded by his VILLUM Young Investigator Grant [13154]; European Research Council (ERC) Consolidator Grant [770827]; Spanish State Research Agency AEI 10.13039/501100011033 [PID2019-105500GB-I00]; I.J. was supported in part by funding from Natural Sciences Research Council [NSERC #203475], Canada Foundation for Innovation [CFI #225404, #30865]; Ontario Research Fund [RDI #34876, RE010-020]; IBM and Ian Lawson van Toch Fund; S.L. has received funding from the European Union’s Horizon 2020 research and innovation programme [965193] for DECIDER. Funding for open access charge: Horizon Europe project Repo4EU.Peer ReviewedPostprint (published version

Muscle Contraction and Force: the Importance of an Ancillary Network, Nutrient Supply and Waste Removal

Muscle contraction studies often focus solely on myofibres and the proteins known to be involved in the processes of sarcomere shortening and cross-bridge cycling, but skeletal muscle also comprises a very elaborate ancillary network of capillaries, which not only play a vital role in terms of nutrient delivery and waste product removal, but are also tethered to surrounding fibres by collagen ”wires”. This paper therefore addresses aspects of the ancillary network of skeletal muscle at both a microscopic and functional level in order to better understand its role holistically as a considerable contributor to force transfer within muscular tissue

Drugst.One -- A plug-and-play solution for online systems medicine and network-based drug repurposing

In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerged to identify potential drug repurposing candidates. However, these tools often require complex installation and lack intuitive visual network mining capabilities. To tackle these challenges, we introduce Drugst.One, a platform that assists specialized computational medicine tools in becoming user-friendly, web-based utilities for drug repurposing. With just three lines of code, Drugst.One turns any systems biology software into an interactive web tool for modeling and analyzing complex protein-drug-disease networks. Demonstrating its broad adaptability, Drugst.One has been successfully integrated with 21 computational systems medicine tools. Available at https://drugst.one, Drugst.One has significant potential for streamlining the drug discovery process, allowing researchers to focus on essential aspects of pharmaceutical treatment research.Comment: 45 pages, 6 figures, 7 table

Drugst.One - a plug-and-play solution for online systems medicine and network-based drug repurposing.

In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerged to identify potential drug repurposing candidates. However, these tools often require complex installation and lack intuitive visual network mining capabilities. To tackle these challenges, we introduce Drugst.One, a platform that assists specialized computational medicine tools in becoming user-friendly, web-based utilities for drug repurposing. With just three lines of code, Drugst.One turns any systems biology software into an interactive web tool for modeling and analyzing complex protein-drug-disease networks. Demonstrating its broad adaptability, Drugst.One has been successfully integrated with 21 computational systems medicine tools. Available at https://drugst.one, Drugst.One has significant potential for streamlining the drug discovery process, allowing researchers to focus on essential aspects of pharmaceutical treatment research

Experiencias de lucha y organización en el Astillero Río Santiago durante 1975

La siguiente ponencia es resultado de una investigación sobre los procesos de lucha y organización de los trabajadores del Astillero Río Santiago. La misma fue realizada en el marco de nuestra Tesina de Licenciatura en Sociología. Nos proponemos en ella realizar un acercamiento a las características de las luchas de los obreros del Astillero durante el año 1975. Haremos hincapié en las reivindicaciones y demandas de los trabajadores durante el periodo en cuestión. Asimismo prestamos especial atención a la relación de los trabajadores con los representantes sindicales oficiales. Este trabajo nos servirá para destacar una serie de elementos centrales para comprender la dinámica social y política en la década del ´70: 1) que en las bases obreras del Astillero había una predisposición a la lucha bastante importante, 2) que tal predisposición incomodaba a la dirigencia sindical oficial peronista porque en varias ocasiones los trabajadores realizaban acciones sobrepasando sus indicaciones, 3) que en los sectores de vanguardia del movimiento obrero primó el método asambleario para tomar las decisiones, 4) que con el desarrollo de la lucha los obreros del Astillero construyeron junto trabajadores de otros establecimientos organismos de conducción alternativos.Facultad de Humanidades y Ciencias de la Educació

Experiencias de lucha y organización en el Astillero Río Santiago durante 1975

Fil: Abovsky, Leandro. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina