A Bayesian analysis of the 27 highest energy cosmic rays detected by the Pierre Auger Observatory

It is possible that ultra-high energy cosmic rays (UHECRs) are generated by active galactic nuclei (AGNs), but there is currently no conclusive evidence for this hypothesis. Several reports of correlations between the arrival directions of UHECRs and the positions of nearby AGNs have been made, the strongest detection coming from a sample of 27 UHECRs detected by the Pierre Auger Observatory (PAO). However, the PAO results were based on a statistical methodology that not only ignored some relevant information (most obviously the UHECR arrival energies but also some of the information in the arrival directions) but also involved some problematic fine-tuning of the correlation parameters. Here we present a fully Bayesian analysis of the PAO data (collected before 2007 September), which makes use of more of the available information, and find that a fraction F_AGN = 0.15^(+0.10)_(-0.07) of the UHECRs originate from known AGNs in the Veron-Cetty & Veron (VCV) catalogue. The hypothesis that all the UHECRs come from VCV AGNs is ruled out, although there remains a small possibility that the PAO-AGN correlation is coincidental (F_AGN = 0.15 is 200 times as probable as F_AGN = 0.00).Comment: MNRAS, accepted; 8 pages, 7 figure

Layoff and Employment Guarantee Announcements: How Do Shareholders Respond?

Event study methodology was used to assess the effects of both layoff and employment guarantee announcements on shareholder returns. The Wall Street Journal was used to identify 368 firms that announced layoffs and 13 firms that announced employment guarantees in 1993 or 1994. The results were used to test the validity of four hypotheses: labor-cost, efficiency, industrial-relation-effect, and signalling-effect hypotheses. The results show that both layoff announcements and employment guarantee announcements induced a decrease in the shareholder returns of the firms that made the announcements. Each of the above four models received partial support.layoffs; downsizing; event study; employment guarantee

A statistical test of emission from unresolved point sources

We describe a simple test of the spatial uniformity of an ensemble of discrete events. Given an estimate for the point source luminosity function and an instrumental point spread function (PSF), a robust upper bound on the fractional point source contribution to a diffuse signal can be found. We verify with Monte Carlo tests that the statistic has advantages over the two-point correlation function for this purpose, and derive analytic estimates of the statistic's mean and variance as a function of the point source contribution. As a case study, we apply this statistic to recent gamma-ray data from the Fermi Large Area Telescope (LAT), and demonstrate that at energies above 10 GeV, the contribution of unresolved point sources to the diffuse emission is small in the region relevant for study of the WMAP Haze.Comment: 11 pages, 7 figures. Final version, accepted by Mon. Not. R. Astron. Soc. The definitive version is available at www.blackwell-synergy.com

Flow-Induced Voltage Generation Over Monolayer Graphene in the Presence of Herringbone Grooves

While flow-induced voltage over a graphene layer has been reported, its origin remains unclear. In our previous study, we suggested different mechanisms for different experimental configurations: phonon dragging effect for the parallel alignment and an enhanced out-of-plane phonon mode for the perpendicular alignment (Appl. Phys. Lett. 102:063116, 2011). In order to further examine the origin of flow-induced voltage, we introduced a transverse flow component by integrating staggered herringbone grooves in the microchannel. We found that the flow-induced voltage decreased significantly in the presence of herringbone grooves in both parallel and perpendicular alignments. These results support our previous interpretation

Field Theory Supertubes

Starting with intersecting M2-branes in M-theory, the IIA supertube can be found by compactification with a boost to the speed of light in the compact dimension. A similar procedure applied to Donaldson-Uhlenbeck-Yau instantons on \bC^3, viewed as intersecting membranes of 7D supersymmetric Yang-Mills (SYM) theory, yields (for finite boost) a new set of 1/4 BPS equations for 6D SYM-Higgs theory, and (for infinite boost) a generalization of the dyonic instanton equations of 5D SYM-Higgs theory, solutions of which are interpreted as Yang-Mills supertubes and realized as configurations of IIB string theory.Comment: 11 pages. Contribution to Strings '04. Revised to include minor corrections and additional reference

Characterization of GDP-mannose Pyrophosphorylase from Escherichia Coli O157:H7 EDL933 and Its Broad Substrate Specificity

GDP-mannose pyrophosphorylase gene (ManC) of Escherichia coli (E. coli) O157 was cloned and expressed as a highly soluble protein in E. coli BL21 (DE3). The enzyme was subsequently purified using hydrophobic and ion exchange chromatographies. ManC showed very broad substrate specificities for four nucleotides and various hexose-1-phosphates, yielding ADP-mannose, CDP-mannose, UDP-mannose, GDP-mannose, GDP-glucose and GDP-2-deoxy-glucose

Equivalent Linear Two-Body Equations for Many-Body Systems

A method has been developed for obtaining equivalent linear two-body equations (ELTBE) for the system of many ($N$) bosons using the variational principle. The method has been applied to the one-dimensional N-body problem with pair-wise contact interactions (McGurie-Yang N-body problem) and to the dilute Bose-Einstein condensation (BEC) of atoms in anisotropic harmonic traps at zero temperature. For both cases, it is shown that the method gives excellent results for large N.Comment: 12 pages, Late

One-pot Enzymatic Synthesis of Deoxy-thymidine-diphosphate (TDP)-2-deoxy-∝-d-glucose Using Phosphomannomutase

Production of deoxy-thymidine-diphosphate (TDP)-sugars as substrates of glycosyltransferases, has been one of main hurdles for combinatorial antibiotic biosynthesis, which combines sugar moiety with aglycon of various antibiotics. Here, we report the one-pot enzymatic synthesis of TDP-2-deoxy-glucose employing high efficient TMP kinase (TMK; E.C. 2.7.2.12), acetate kinase (ACK; E.C. 2.7.1.21), and TDP-glucose synthase (TGS; E.C. 2.7.7.24) with phosphomannomutase (PMM; E.C. 5.4.2.8). In this study, replacing phosphoglucomutase (PGM; E.C. 5.4.2) by PMM from Escherichia coli gave four times higher specific activity on 2-deoxy-6-phosphate glucose, suggesting that the activity on 2-deoxy-glucose-6-phosphate was mainly affected by PMM activity, not PGM activity. Using an in vitro system starting from TMP and 2-deoxy-glucose-6-phosphate glucose, TDP-2-deoxy-glucose (63% yield) was successfully synthesized. Considering low productivity of NDP-sugars from cheap starting materials, this paper showed how production of NDP-sugars could be enhanced by controlling mutase activity

Preparative Synthesis of dTDP-L-Rhamnose Through Combined Enzymatic Pathways

dTDP-L-rhamnose, an important precursor of O-antigen, was prepared on a large scale from dTMP by executing an one-pot reaction in which six enzymes are involved. Two enzymes, dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase and dTDP-4-keto-rhamnose reductase, responsible for the conversion of dTDP-4-keto-6-deoxy- D-glucose to dTDP-L-rhamnose, were isolated from their putative sequences in the genome of Mesorhizobium loti, functionally expressed in Escherichia coli, and their enzymatic activities were identified. The two enzymes were combined with an enzymatic process for dTDP-4- keto-6-deoxy-D-glucose involving TMP kinase, acetate kinase, dTDP-glucose synthase, and dTDP-glucose 4,6- dehydratase, which allowed us to achieve a preparative scale synthesis of dTDP-L-rhamnose using dTMP and glucose-1-phosphate as starting materials. About 82% yield of dTDP-L-rhamnose was obtained based on initial dTMP concentration at 20 mM dTMP, 1 mM ATP, 10 mM NADH, 60 mM acetyl phosphate, and 80 mM glucose-1- phosphate. From the reaction with 20 ml volume, approximately 180 mg of dTDP-L-rhamnose was obtained in an overall yield of 60% after two-step purification, that is, anion exchange chromatography and gel filtration for desalting. The purified product was identifiedbyHPLC, ESI-MS,andNMR,showingabout95%purity