125 research outputs found

    Dynamics of the Chiral Magnetic Effect in a weak magnetic field

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    We investigate the real-time dynamics of the chiral magnetic effect in quantum electrodynamics (QED) and quantum chromodynamics (QCD). We consider a field configuration of parallel (chromo)electric and (chromo)magnetic fields with a weak perpendicular electromagnetic magnetic field. The chiral magnetic effect induces an electromagnetic current along this perpendicular magnetic field, which we will compute using linear response theory. We discuss specific results for a homogeneous sudden switch-on and a pulsed (chromo)electric field in a static and homogeneous (chromo)magnetic field. Our methodology can be easily extended to more general situations. The results are useful for investigating the chiral magnetic effect with heavy ion collisions and with lasers that create strong electromagnetic fields. As a side result we obtain the rate of chirality production for massive fermions in parallel electric and magnetic fields that are static and homogeneous.Comment: 13 pages, 7 figures, revte

    Electromagnetic field evolution in relativistic heavy-ion collisions

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    The hadron string dynamics (HSD) model is generalized to include the creation and evolution of retarded electromagnetic fields as well as the influence of the magnetic and electric fields on the quasiparticle propagation. The time-space structure of the fields is analyzed in detail for non-central Au+Au collisions at sNN=\sqrt{s_{NN}}=200 GeV. It is shown that the created magnetic field is highly inhomogeneous but in the central region of the overlapping nuclei it changes relatively weakly in the transverse direction. For the impact parameter b=b=10 fm the maximal magnetic field - perpendicularly to the reaction plane - is obtained of order eBy/mπ2eB_y/m_\pi^2\sim5 for a very short time \sim 0.2 fm/c, which roughly corresponds to the time of a maximal overlap of the colliding nuclei. We find that at any time the location of the maximum in the eByeB_y distribution correlates with that of the energy density of the created particles. In contrast, the electric field distribution, being also highly inhomogeneous, has a minimum in the center of the overlap region. Furthermore, the field characteristics are presented as a function of the collision energy and the centrality of the collisions. To explore the effect of the back reaction of the fields on hadronic observables a comparison of HSD results with and without fields is exemplified. Our actual calculations show no noticeable influence of the electromagnetic fields - created in heavy-ion collisions - on the effect of the electric charge separation with respect to the reaction plane.Comment: 17 pages, 22 figures, title changed by editor, accepted for PR

    Chiral Magnetic Effect on the Lattice

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    We review recent progress on the lattice simulations of the chiral magnetic effect. There are two different approaches to analyze the chiral magnetic effect on the lattice. In one approach, the charge density distribution or the current fluctuation is measured under a topological background of the gluon field. In the other approach, the topological effect is mimicked by the chiral chemical potential, and the induced current is directly measured. Both approaches are now developing toward the exact analysis of the chiral magnetic effect.Comment: to appear in Lect. Notes Phys. "Strongly interacting matter in magnetic fields" (Springer), edited by D. Kharzeev, K. Landsteiner, A. Schmitt, H.-U. Ye

    Lattice QCD Simulations in External Background Fields

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    We discuss recent results and future prospects regarding the investigation, by lattice simulations, of the non-perturbative properties of QCD and of its phase diagram in presence of magnetic or chromomagnetic background fields. After a brief introduction to the formulation of lattice QCD in presence of external fields, we focus on studies regarding the effects of external fields on chiral symmetry breaking, on its restoration at finite temperature and on deconfinement. We conclude with a few comments regarding the effects of electromagnetic background fields on gluodynamics.Comment: 31 pages, 10 figures, minor changes and references added. To appear in Lect. Notes Phys. "Strongly interacting matter in magnetic fields" (Springer), edited by D. Kharzeev, K. Landsteiner, A. Schmitt, H.-U. Ye

    Deconfinement and Chiral Symmetry Restoration in a Strong Magnetic Background

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    We perform a model study of deconfinement and chiral symmetry restoration in a strong magnetic background. We use a Nambu-Jona Lasinio model with the Polyakov loop, taking into account a possible dependence of the coupling on the Polyakov loop expectation value, as suggested by the recent literature. Our main result is that, within this model, the deconfinement and chiral crossovers of QCD in strong magnetic field are entangled even at the largest value of eBeB considered here, namely eB=30mπ2eB=30 m_\pi^2 (that is, B6×1015B \approx 6\times 10^{15} Tesla). The amount of split that we measure is, at this value of eBeB, of the order of 2%. We also study briefly the role of the 8-quark term on the entanglement of the two crossovers. We then compare the phase diagram of this model with previous results, as well as with available Lattice data.Comment: 12 pages, 6 figures, RevTeX 4-1 style. Some reference added. Some typos corrected. To appear on Physical Review

    Murine factor H co-produced in yeast with protein disulfide isomerase ameliorated C3 dysregulation in factor H-Deficient mice

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    Recombinant human factor H (hFH) has potential for treating diseases linked to aberrant complement regulation including C3 glomerulopathy (C3G) and dry age-related macular degeneration. Murine FH (mFH), produced in the same host, is useful for pre-clinical investigations in mouse models of disease. An abundance of FH in plasma suggests high doses, and hence microbial production, will be needed. Previously, Pichia pastoris produced useful but modest quantities of hFH. Herein, a similar strategy yielded miniscule quantities of mFH. Since FH has 40 disulfide bonds, we created a P. pastoris strain containing a methanol-inducible codon-modified gene for protein-disulfide isomerase (PDI) and transformed this with codon-modified DNA encoding mFH under the same promoter. What had been barely detectable yields of mFH became multiple 10s of mg/L. Our PDI-overexpressing strain also boosted hFH overproduction, by about tenfold. These enhancements exceeded PDI-related production gains reported for other proteins, all of which contain fewer disulfide-stabilized domains. We optimized fermentation conditions, purified recombinant mFH, enzymatically trimmed down its (non-human) N-glycans, characterised its functions in vitro and administered it to mice. In FH-knockout mice, our de-glycosylated recombinant mFH had a shorter half-life and induced more anti-mFH antibodies than mouse serum-derived, natively glycosylated, mFH. Even sequential daily injections of recombinant mFH failed to restore wild-type levels of FH and C3 in mouse plasma beyond 24 hours after the first injection. Nevertheless, mFH functionality appeared to persist in the glomerular basement membrane because C3-fragment deposition here, a hallmark of C3G, remained significantly reduced throughout and beyond the ten-day dosing regimen
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