7,479 research outputs found
Mechanisms for Lasing with Cold Atoms as the Gain Medium
We realize a laser with a cloud of cold rubidium atoms as gain medium, placed
in a low-finesse cavity. Three different regimes of laser emission are observed
corresponding respectively to Mollow, Raman and Four Wave Mixing mechanisms. We
measure an output power of up to 300 W and present the main properties of
these different lasers in each regime
Treatment of Young Children with HIV Infection: Using Evidence to Inform Policymakers
PMCID: PMC3404108This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Chimera States for Coupled Oscillators
Arrays of identical oscillators can display a remarkable spatiotemporal
pattern in which phase-locked oscillators coexist with drifting ones.
Discovered two years ago, such "chimera states" are believed to be impossible
for locally or globally coupled systems; they are peculiar to the intermediate
case of nonlocal coupling. Here we present an exact solution for this state,
for a ring of phase oscillators coupled by a cosine kernel. We show that the
stable chimera state bifurcates from a spatially modulated drift state, and
dies in a saddle-node bifurcation with an unstable chimera.Comment: 4 pages, 4 figure
Experimental study of direct photon emission in K- --> pi- pi0 gamma decay using ISTRA+ detector
The branching ratio in the charged-pion kinetic energy region of 55 to 90 MeV
for the direct photon emission in the K- --> pi- pi0 gamma decay has been
measured using in-flight decays detected with the ISTRA+ setup operating in the
25 GeV/c negative secondary beam of the U-70 PS. The value
Br(DE)=[0.37+-0.39(stat)+-0.10(syst)]*10^(-5) obtained from the analysis of 930
completely reconstructed events is consistent with the average value of two
stopped-kaon experiments, but it differs by 2.5 standard deviations from the
average value of three in-flight-kaon experiments. The result is also compared
with recent theoretical predictions.Comment: 13 pages, 8 figure
Elastic Scattering and Direct Detection of Kaluza-Klein Dark Matter
Recently a new dark matter candidate has been proposed as a consequence of
universal compact extra dimensions. It was found that to account for
cosmological observations, the masses of the first Kaluza-Klein modes (and thus
the approximate size of the extra dimension) should be in the range 600-1200
GeV when the lightest Kaluza-Klein particle (LKP) corresponds to the
hypercharge boson and in the range 1 - 1.8 TeV when it corresponds to a
neutrino. In this article, we compute the elastic scattering cross sections
between Kaluza-Klein dark matter and nuclei both when the lightest Kaluza-Klein
particle is a KK mode of a weak gauge boson, and when it is a neutrino. We
include nuclear form factor effects which are important to take into account
due to the large LKP masses favored by estimates of the relic density. We
present both differential and integrated rates for present and proposed
Germanium, NaI and Xenon detectors. Observable rates at current detectors are
typically less than one event per year, but the next generation of detectors
can probe a significant fraction of the relevant parameter space.Comment: 23 pages, 11 figures; v2,v3: Ref. added, discussion improved,
conclusions unchanged. v4: Introduction was expanded to be more appropriate
for non experts. Various clarifications added in the text. Version to be
published in New Journal of Physic
New summing algorithm using ensemble computing
We propose an ensemble algorithm, which provides a new approach for
evaluating and summing up a set of function samples. The proposed algorithm is
not a quantum algorithm, insofar it does not involve quantum entanglement. The
query complexity of the algorithm depends only on the scaling of the
measurement sensitivity with the number of distinct spin sub-ensembles. From a
practical point of view, the proposed algorithm may result in an exponential
speedup, compared to known quantum and classical summing algorithms. However in
general, this advantage exists only if the total number of function samples is
below a threshold value which depends on the measurement sensitivity.Comment: 13 pages, 0 figures, VIth International Conference on Quantum
Communication, Measurement and Computing (Boston, 2002
Prediction of impending type 1 diabetes through automated dual-label measurement of proinsulin:C-peptide ratio
Background : The hyperglycemic clamp test, the gold standard of beta cell function, predicts impending type 1 diabetes in islet autoantibody-positive individuals, but the latter may benefit from less invasive function tests such as the proinsulin: C-peptide ratio (PI:C). The present study aims to optimize precision of PI:C measurements by automating a dual-label trefoil-type time-resolved fluorescence immunoassay (TT-TRFIA), and to compare its diagnostic performance for predicting type 1 diabetes with that of clamp-derived C-peptide release.
Methods : Between-day imprecision (n = 20) and split-sample analysis (n = 95) were used to compare TT-TRFIA (Auto Delfia, Perkin-Elmer) with separate methods for proinsulin (in-house TRFIA) and C-peptide (Elecsys, Roche). High-risk multiple autoantibody-positive firstdegree relatives (n = 49; age 5-39) were tested for fasting PI:C, HOMA2-IR and hyperglycemic clamp and followed for 20-57 months (interquartile range).
Results : TT-TRFIA values for proinsulin, C-peptide and PI:C correlated significantly (r(2) = 0.96-0.99; P<0.001) with results obtained with separate methods. TT-TRFIA achieved better between-day % CV for PI:C at three different levels (4.5-7.1 vs 6.7-9.5 for separate methods). In high-risk relatives fasting PI:C was significantly and inversely correlated ( r(s) = -0.596; P<0.001) with first-phase C-peptide release during clamp ( also with second phase release, only available for age 12-39 years; n = 31), but only after normalization for HOMA2-IR. In ROC- and Cox regression analysis, HOMA2-IR-corrected PI:C predicted 2-year progression to diabetes equally well as clamp-derived C-peptide release.
Conclusions : The reproducibility of PI:C benefits from the automated simultaneous determination of both hormones. HOMA2-IR-corrected PI:C may serve as a minimally invasive alternative to the more tedious hyperglycemic clamp test
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