Within-burst synchrony changes for coupled elliptic bursters

We study the appearance of a novel phenomenon for linearly coupled identical bursters: synchronized bursts where there are changes of spike synchrony within each burst. The examples we study are for normal form elliptic bursters where there is a periodic slow passage through a Bautin (codimension two degenerate Andronov-Hopf) bifurcation. This burster has a subcritical Andronov-Hopf bifurcation at the onset of repetitive spiking while end of burst occurs via a fold limit cycle bifurcation. We study synchronization behavior of two and three Bautin-type elliptic bursters for a linear direct coupling scheme. Burst synchronization is known to be prevalent behavior among such coupled bursters, while spike synchronization is more dependent on the details of the coupling. We note that higher order terms in the normal form that do not affect the behavior of a single burster can be responsible for changes in synchrony pattern; more precisely, we find within-burst synchrony changes associated with a turning point in the spiking frequency.Comment: 17 pages, 13 figures, 2 table

Determinants of Asian Democratisation (1981-2005)

As a culturally distinctive region, Asia was chosen as the sample for this study. This empirical study investigated what the major trends of democratisation were in Asia between 1981 and 2005: why some countries became democratic while other countries failed to follow suit during that period. The main research hypothesis was: “That is it was mainly economic development that drove democratisation in Asia between 1981 and 2005”. Although some studies have studied the impact of economic development on democratisation in Asia, their findings have been inconclusive and focuses sometimes different. [To investigate the research hypothesis, 24 Asian countries were selected…measurement tools used etc…] For this research work, statistical and case study methods were applied. The data used in the analyses were collected from established data sources e.g. Freedom House (Freedom in the World, n.d.) and United Nations Statistics Division (UN Stat, n.d.). Repeated Measures in Linear Mixed Modeling (LMM) were used to analyse the quantitative data. Three case studies supplemented the findings of statistical analyses. Historical information and institutional and legal facts were also used in the case studies. This study found that increases in the level of economic development along with its equitable distribution in society and positive roles of political actors increase the level of democratisation in Asia. Some pro-democratic political and social institutions, such as tradition of parliamentarianism, and international organisations, for example Bretton wood institutions, also led to democratisation. A low extent of national political divide was found to result in a considerably high level of democratisation in a country where confrontation between major political forces is the main feature of politics. This study also found that a partial democracy with Asian values, economic legitimacy, a lack of corruption and a “systematic control” over opposition politicians can survive, and is not prone to higher level of democratisation. The Taiwan case revealed that, amongst other factors, the role of political actors and economic equity along with economic development is also vital for democratisation. The Singapore case explained how a “hybrid regime” in a rich country outsmarts democratisation. The study of Bangladesh provides an idea about other elements, e.g. lower level of political confrontation, that push for higher levels of democratisation

Chk1 activity is required for BAK multimerization in association with PUMA during mitochondrial apoptosis

BACKGROUND: The Bcl-2 protein BAK is a key player in mitochondrial apoptosis and responds to a myriad of different death signals. Activation of BAK is a multistep process that involves a number of conformational changes mediated by BH3-only proteins or p53 which leads to BAK multimerization and pore formation in the mitochondrial outer membrane. We previously reported that BAK activation is dependent upon dephosphorylation of both tyrosine and serine residues. Further, recent reports demonstrated that PP2A activity is required for BAK multimerization. Since Chk1, a checkpoint kinase involved in the activation of G2 checkpoint, is regulated by PP2A, we therefore hypothesized that Chk1 is involved in BAK multimerization during cell cycle arrest upon severe DNA damage. FINDINGS: We now show that treatment of HCT116-WT BAK cells with a Chk1 inhibitor impaired BAK dimerization and mutimerization when treated with the DNA damaging agents UV or etoposide. As a result there is a concomitant decrease of cytochrome c release from isolated mitochondria challenged with tBid protein and failure in the activation of caspase3. Interestingly, co-immunoprecipitation studies suggest that Chk1 is required for recruitment of BH3- only protein PUMA to BAK. We also showed that Chk1 is associated with BAK upon DNA damage. CONCLUSION: These findings novelly demonstrate the involvement of a checkpoint kinase Chk1 is required for BAK activation and underscores the importance of involvement of Chk1 in mitochondrial apoptosis upon severe DNA damage

Modified differential evolution based on global competitive ranking for engineering design optimization problems

Engineering design optimization problems are formulated as large-scale mathematical programming problems with nonlinear objective function and constraints. Global optimization finds a solution while satisfying the constraints. Differential evolution is a population-based heuristic approach that is shown to be very efficient to solve global optimization problems with simple bounds. In this paper, we propose a modified differential evolution introducing self-adaptive control parameters, modified mutation, inversion operation and modified selection for obtaining global optimization. To handle constraints effectively, in modified selection we incorporate global competitive ranking which strikes the right balance between the objective function and the constraint violation. Sixteen well-known engineering design optimization problems are considered and the results compared with other solution methods. It is shown that our method is competitive when solving these problems.Fundação para a Ciência e a Tecnologia (FCT

A modified differential evolution based solution technique for economic dispatch problems

Economic dispatch (ED) plays one of the major roles in power generation systems. The objective of economic dispatch problem is to find the optimal combination of power dispatches from different power generating units in a given time period to minimize the total generation cost while satisfying the specified constraints. Due to valve-point loading effects the objective function becomes nondifferentiable and has many local minima in the solution space. Traditional methods may fail to reach the global solution of ED problems. Most of the existing stochastic methods try to make the solution feasible or penalize an infeasible solution with penalty function method. However, to find the appropriate penalty parameter is not an easy task. Differential evolution is a population-based heuristic approach that has been shown to be very efficient to solve global optimization problems with simple bounds. In this paper, we propose a modified differential evolution based solution technique along with a tournament selection that makes pair-wise comparison among feasible and infeasible solutions based on the degree of constraint violation for economic dispatch problems. We reformulate the nonsmooth objective function to a smooth one and add nonlinear inequality constraints to original ED problems. We consider five ED problems and compare the obtained results with existing standard deterministic NLP solvers as well as with other stochastic techniques available in literature.Fundação para a Ciência e a Tecnologia (FCT

Modified constrained differential evolution for solving nonlinear global optimization problems

Nonlinear optimization problems introduce the possibility of multiple local optima. The task of global optimization is to find a point where the objective function obtains its most extreme value while satisfying the constraints. Some methods try to make the solution feasible by using penalty function methods, but the performance is not always satisfactory since the selection of the penalty parameters for the problem at hand is not a straightforward issue. Differential evolution has shown to be very efficient when solving global optimization problems with simple bounds. In this paper, we propose a modified constrained differential evolution based on different constraints handling techniques, namely, feasibility and dominance rules, stochastic ranking and global competitive ranking and compare their performances on a benchmark set of problems. A comparison with other solution methods available in literature is also provided. The convergence behavior of the algorithm to handle discrete and integer variables is analyzed using four well-known mixed-integer engineering design problems. It is shown that our method is rather effective when solving nonlinear optimization problems.Fundação para a Ciência e a Tecnologia (FCT

Passive radiative "thermostat" enabled by phase-change photonic nanostructures

A thermostat senses the temperature of a physical system and switches heating or cooling devices on or off, regulating the flow of heat to maintain the system's temperature near a desired setpoint. Taking advantage of recent advances in radiative heat transfer technologies, here we propose a passive radiative "thermostat" based on phase-change photonic nanostructures for thermal regulation at room temperature. By self-adjusting their visible to mid-IR absorptivity and emissivity responses depending on the ambient temperature, the proposed devices use the sky to passively cool or heat during day-time using the phase-change transition temperature as the setpoint, while at night-time temperature is maintained at or below ambient. We simulate the performance of a passive nanophotonic thermostat design based on vanadium dioxide thin films, showing daytime passive cooling (heating) with respect to ambient in hot (cold) days, maintaining an equilibrium temperature approximately locked within the phase transition region. Passive radiative thermostats can potentially enable novel thermal management technologies, e.g. to moderate diurnal temperature in regions with extreme annual thermal swings