Spatial repellents: from discovery and development to evidence-based validation

International public health workers are challenged by a burden of arthropod-borne disease that remains elevated despite best efforts in control programmes. With this challenge comes the opportunity to develop novel vector control paradigms to guide product development and programme implementation. The role of vector behaviour modification in disease control was first highlighted several decades ago but has received limited attention within the public health community. This paper presents current evidence highlighting the value of sub-lethal agents, specifically spatial repellents, and their use in global health, and identifies the primary challenges towards establishing a clearly defined and recommended role for spatial repellent products in disease control

Tools and Strategies for Malaria Control and Elimination: What Do We Need to Achieve a Grand Convergence in Malaria?

Progress made in malaria control during the past decade has prompted increasing global dialogue on malaria elimination and eradication. The product development pipeline for malaria has never been stronger, with promising new tools to detect, treat, and prevent malaria, including innovative diagnostics, medicines, vaccines, vector control products, and improved mechanisms for surveillance and response. There are at least 25 projects in the global malaria vaccine pipeline, as well as 47 medicines and 13 vector control products. In addition, there are several next-generation diagnostic tools and reference methods currently in development, with many expected to be introduced in the next decade. The development and adoption of these tools, bolstered by strategies that ensure rapid uptake in target populations, intensified mechanisms for information management, surveillance, and response, and continued financial and political commitment are all essential to achieving global eradication

Respuesta conductual de Aedes aegypti (Linneaus, 1762) frente adulticidas piretroides de uso frecuente en Salud Pública

Objetivos. Evaluar la respuesta conductual de la generación F1 de Aedes aegyti (L) colectados en el área metropolitana de Monterrey (Nuevo León, México) frente a tres adulticidas piretroides de uso frecuente en salud pública. Materiales y métodos. Se utilizó un sistema modular novedoso denominado HITSS (High-Throughput Screening System), para evaluar dos respuestas de comportamiento (irritación de contacto y repelencia espacial), así como la toxicidad de tres insecticidas DDT, permetrina y bifentrina a diferentes concentraciones (0,025, 0,25, 25 y 250 nmol/cm2). Resultados. En la concentración 2,5 nmol/cm2, el DDT (4,3 ± 2,4) y la permetrina (8,0 ± 1,4) son los insecticidas que tienen mayor efecto irritante (p<0,05); la bifentrina requiere dosis 20 veces más alta para lograr efectos similares. En repelencia espacial, los tres insecticidas evaluados producen respuestas similares en todas las concentraciones; para DDT de 7 a 14%; permetrina de 9 a 15% y bifentrina de 19 a 27%. La permetrina y bifentrina a concentraciones 0,025 nmol/cm2, producen efectos knockdown superiores a 34%, con una mortalidad 19%, el DDT requiere concentraciones diez veces más alta para lograr efectos similares. Conclusiones. El sistema HITTS puede ser usado para evaluar la respuesta conductual frente a insecticidas

Review of Family and Justice in the Archives: Historical Perspectives on Intimacy and the Law

Review of Family and Justice in the Archives: Historical Perspectives on Intimacy and the Law

English Homilies and English Miracle Plays

A priest who is also a student of English literature is naturally interested in the manifestations of the religious spirit as it has appeared in our literature. Acquaintance with a few finely poetic passages in the homilies of Aelfric led me to suspect that perhaps our ancient homiletic literature was worthy of more attention than it seemed to have received at the hands of scholars. Consequently, when the opportunity for producing an original study presented itself, the field was waiting for me; that of the early English homilies

The poisonous wine from Catalonia: rebellion in Spanish Louisiana during the Ulloa, O\u27Reilly, and Carondelet administrations

Spanish rule in Louisiana was bracketed by periods of unrest. Using the criteria for rebellion developed by political scientist Claude E. Welch Jr., in Anatomy of Rebellion to compare the 1768 rebellion under Governor Antonio de Ulloa, and demonstrations of discontent in the 1790’s under Baron Francisco Luis Carondelet, one is able to draw out similarities, contrasts, and continuities in factors causal to political unrest. The most powerful of these causal factors were the economic troubles, geographic marginality, ethnic tensions, weak authority, and unsuccessful attempts to reform the colony’s commercial system. Methods employed by the Spanish administrations to contain or mitigate the discontent largely failed, leading to episodes of violent popular political contention. The roots of Louisiana’s problems ran deep. By the arrival of the Spaniards, the colony had been largely neglected by the French crown. Suffering shortages of food, and economic strife, the colonial elite formed their own alternate, and often illegal, structures of power and support. The 1766 imposition of Spanish rule threatened those structures. In 1768, discontented members of the Louisiana Superior Council staged a coup, driving Spanish governor Antonio de Ulloa out of the colony. Lieutenant General Alejandro O’Reilly restored order to the colony in 1769. O’Reilly demonstrated effective means of control over a discontented populace, which stood in stark relief to the weaknesses, neglect and disorder of the previous Spanish administration. In the early 1790’s a number of factors sparked new fears of rebellion in Louisiana. Disruptions of trade caused by war with France, attempts to integrate Louisiana into the Spanish mercantile system, shifts in agriculture and a shortage of specie backed currency once again agitated the colonial elite. At the same time an influx of revolutionary propaganda from the French Republic threatened to spark old ethnic tensions while tales of the Haitian revolution brought fears of slave revolt in the colony. Baron Carondelet utilized an increased military presence, information control, incorporation of colonial leaders into his administrative structure, and the fear of slave revolt to contain demonstrations of popular discontent. While his administration saw an increase in political violence, Carondelet prevented widespread rebellion

Potential community-based control by use of plastic film to block aedes aegypti (L.) egg adhesion

Abstract. Monitoring and control programs for yellow fever mosquito, Aedes aegypti (L.), usually do not focus on the egg as a potential target for control. The egg is the most numerous life stage but is invisible to conventional inspection by a sticky pad that attaches it. This laboratory study evaluated the potential ovicidal effect of five commonly used plastics. Plastic liners in oviposition containers were exposed to gravid female mosquitoes in an insectary. The percentage of eggs that hatched was recorded. The plastic liners altered the places where eggs were laid, i.e., 27.0% were glued onto the plastic film, 70.0% remained floating, and 3.0% were submerged. Vinyl blocked most egg adhesion, with a mean of 7.05 ± 10.1 eggs, compared to 170.7 ± 68.6 eggs for the check. Pooled numbers of glued, floating, and submerged eggs showed fewest eggs hatched on vinyl or low-density polyethylene, resulting in the death of 94.7% of the embryos. Plastics waterproofing property might be blocking the hyaluronic acid, the component of the sticky substance of mosquito eggs. Results demonstrated the potential use of plastic strips as an ovicide. Plastics should be studied further for use in community-based programs to control dengue

A Systematic Review of Mosquito Coils and Passive Emanators: Defining Recommendations for Spatial Repellency Testing Methodologies.

Mosquito coils, vaporizer mats and emanators confer protection against mosquito bites through the spatial action of emanated vapor or airborne pyrethroid particles. These products dominate the pest control market; therefore, it is vital to characterize mosquito responses elicited by the chemical actives and their potential for disease prevention. The aim of this review was to determine effects of mosquito coils and emanators on mosquito responses that reduce human-vector contact and to propose scientific consensus on terminologies and methodologies used for evaluation of product formats that could contain spatial chemical actives, including indoor residual spraying (IRS), long lasting insecticide treated nets (LLINs) and insecticide treated materials (ITMs). PubMed, (National Centre for Biotechnology Information (NCBI), U.S. National Library of Medicine, NIH), MEDLINE, LILAC, Cochrane library, IBECS and Armed Forces Pest Management Board Literature Retrieval System search engines were used to identify studies of pyrethroid based coils and emanators with key-words "Mosquito coils" "Mosquito emanators" and "Spatial repellents". It was concluded that there is need to improve statistical reporting of studies, and reach consensus in the methodologies and terminologies used through standardized testing guidelines. Despite differing evaluation methodologies, data showed that coils and emanators induce mortality, deterrence, repellency as well as reduce the ability of mosquitoes to feed on humans. Available data on efficacy outdoors, dose-response relationships and effective distance of coils and emanators is inadequate for developing a target product profile (TPP), which will be required for such chemicals before optimized implementation can occur for maximum benefits in disease control