4,078 research outputs found
Making GDPR Usable: A Model to Support Usability Evaluations of Privacy
We introduce a new model for evaluating privacy that builds on the criteria
proposed by the EuroPriSe certification scheme by adding usability criteria.
Our model is visually represented through a cube, called Usable Privacy Cube
(or UP Cube), where each of its three axes of variability captures,
respectively: rights of the data subjects, privacy principles, and usable
privacy criteria. We slightly reorganize the criteria of EuroPriSe to fit with
the UP Cube model, i.e., we show how EuroPriSe can be viewed as a combination
of only rights and principles, forming the two axes at the basis of our UP
Cube. In this way we also want to bring out two perspectives on privacy: that
of the data subjects and, respectively, that of the controllers/processors. We
define usable privacy criteria based on usability goals that we have extracted
from the whole text of the General Data Protection Regulation. The criteria are
designed to produce measurements of the level of usability with which the goals
are reached. Precisely, we measure effectiveness, efficiency, and satisfaction,
considering both the objective and the perceived usability outcomes, producing
measures of accuracy and completeness, of resource utilization (e.g., time,
effort, financial), and measures resulting from satisfaction scales. In the
long run, the UP Cube is meant to be the model behind a new certification
methodology capable of evaluating the usability of privacy, to the benefit of
common users. For industries, considering also the usability of privacy would
allow for greater business differentiation, beyond GDPR compliance.Comment: 41 pages, 2 figures, 1 table, and appendixe
Beyond Outerplanarity
We study straight-line drawings of graphs where the vertices are placed in
convex position in the plane, i.e., convex drawings. We consider two families
of graph classes with nice convex drawings: outer -planar graphs, where each
edge is crossed by at most other edges; and, outer -quasi-planar graphs
where no edges can mutually cross. We show that the outer -planar graphs
are -degenerate, and consequently that every
outer -planar graph can be -colored, and this
bound is tight. We further show that every outer -planar graph has a
balanced separator of size . This implies that every outer -planar
graph has treewidth . For fixed , these small balanced separators
allow us to obtain a simple quasi-polynomial time algorithm to test whether a
given graph is outer -planar, i.e., none of these recognition problems are
NP-complete unless ETH fails. For the outer -quasi-planar graphs we prove
that, unlike other beyond-planar graph classes, every edge-maximal -vertex
outer -quasi planar graph has the same number of edges, namely . We also construct planar 3-trees that are not outer
-quasi-planar. Finally, we restrict outer -planar and outer
-quasi-planar drawings to \emph{closed} drawings, where the vertex sequence
on the boundary is a cycle in the graph. For each , we express closed outer
-planarity and \emph{closed outer -quasi-planarity} in extended monadic
second-order logic. Thus, closed outer -planarity is linear-time testable by
Courcelle's Theorem.Comment: Appears in the Proceedings of the 25th International Symposium on
Graph Drawing and Network Visualization (GD 2017
Historical influence of soil and water management on sediment and carbon budgets in the United States
This paper is not subject to U.S. copyright. The definitive version was published in Applied Geochemistry 26 (2011): S259, doi:10.1016/j.apgeochem.2011.03.118.The documented history of US soil and water management provides a unique opportunity to examine soil and sediment C storage under conditions of changing management practices. Historical acceleration of erosion due to cultivation has been moderated by improved soil management. Increased construction of dams and locks has expanded areas of aquatic sedimentation in reservoirs and ponds. Enhanced historical sediment deposition rates have been documented in lakes and estuaries. All of these changes have an impact on terrestrial C storage and turnover. The present-day C budget associated with erosion and burial cannot be determined without quantifying the time-dependent changes due to past and present soil and water management
Evolution of the Insertion-Deletion Mutation Rate Across the Tree of Life
Citation: Sung, W., Ackerman, M. S., Dillon, M. M., Platt, T. G., Fuqua, C., Cooper, V. S., & Lynch, M. (2016). Evolution of the Insertion-Deletion Mutation Rate Across the Tree of Life. G3-Genes Genomes Genetics, 6(8), 2583-2591. doi:10.1534/g3.116.030890/-/DC1Mutations are the ultimate source of variation used for evolutionary adaptation, while also being predominantly deleterious and a source of genetic disorders. Understanding the rate of insertion-deletion mutations (indels) is essential to understanding evolutionary processes, especially in coding regions, where such mutations can disrupt production of essential proteins. Using direct estimates of indel rates from 14 phylogenetically diverse eukaryotic and bacterial species, along with measures of standing variation in such species, we obtain results that imply an inverse relationship of mutation rate and effective population size. These results, which corroborate earlier observations on the base-substitution mutation rate, appear most compatible with the hypothesis that natural selection reduces mutation rates per effective genome to the point at which the power of random genetic drift (approximated by the inverse of effective population size) becomes overwhelming. Given the substantial differences in DNA metabolism pathways that give rise to these two types of mutations, this consistency of results raises the possibility that refinement of other molecular and cellular traits may be inversely related to species-specific levels of random genetic drift
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A multicenter evaluation of the efficacy and duration of action of alcaftadine 0.25% and olopatadine 0.2% in the conjunctival allergen challenge model
Background: The purpose of this study was to evaluate the efficacy and duration of action of once-daily dosing with alcaftadine 0.25% ophthalmic solution and olopatadine 0.2% ophthalmic solution as compared with placebo in the prevention of ocular itching, and to directly compare the efficacy of alcaftadine 0.25% with olopatadine 0.2% in the prevention of ocular itching associated with allergic conjunctivitis using the conjunctival allergen challenge model. Methods: Subjects with allergic conjunctivitis (n = 127) were enrolled in a multicenter, double-masked, randomized, active-controlled and placebo-controlled clinical trial. Using the conjunctival allergen challenge model, this study was conducted over the course of approximately 5 weeks. Subjects were randomized into one of three treatment arms: alcaftadine 0.25% ophthalmic solution, olopatadine 0.2% ophthalmic solution, or placebo. Study medications were administered twice over the course of the trial. The primary efficacy measure for the study was ocular itching evaluated by the subject at 3, 5, and 7 minutes post challenge. Secondary endpoints, measured at 7, 15, and 20 minutes post challenge, included conjunctival, ciliary, and episcleral redness, lid swelling, chemosis, and tearing. Duration of action was measured at 16 and 24 hours post-instillation of the study medication at visits 3 and 4, respectively. Results: For the primary measure of ocular itching, both actives, alcaftadine 0.25% and olopatadine 0.2%, were statistically superior to placebo at all three measured time points for both the 16-hour and 24-hour measures (P < 0.0001). Eyes treated with alcaftadine 0.25% had numerically lower mean ocular itching scores than eyes treated with olopatadine 0.2% at every time point, and this difference was statistically significant at the 3-minute time point 16 hours post instillation (P = 0.026). Eyes treated with alcaftadine 0.25% and with olopatadine 0.2% displayed significantly less lid swelling relative to placebo at every time point for the 16-hour and 24-hour post-instillation visits (P < 0.005). Alcaftadine 0.25% was the only active treatment that provided statistically significant relief of chemosis at every time point of the 24-hour post-instillation visit. Conclusion: Both the alcaftadine 0.25% and olopatadine 0.2% ophthalmic solutions provided highly effective relief of ocular itching at both 16 and 24 hours post-instillation. Treatment differences between the actives were most pronounced at the earliest time point (3 minutes post-challenge) following conjunctival allergen challenge (16 hours), when alcaftadine 0.25% ophthalmic solution was statistically superior to olopatadine 0.2% ophthalmic solution. Alcaftadine 0.25% was the only treatment to provide significant relief from chemosis at both 16 and 24 hours post-instillation. Both active treatments and placebo were generally safe and well tolerated
On Coloring Resilient Graphs
We introduce a new notion of resilience for constraint satisfaction problems,
with the goal of more precisely determining the boundary between NP-hardness
and the existence of efficient algorithms for resilient instances. In
particular, we study -resiliently -colorable graphs, which are those
-colorable graphs that remain -colorable even after the addition of any
new edges. We prove lower bounds on the NP-hardness of coloring resiliently
colorable graphs, and provide an algorithm that colors sufficiently resilient
graphs. We also analyze the corresponding notion of resilience for -SAT.
This notion of resilience suggests an array of open questions for graph
coloring and other combinatorial problems.Comment: Appearing in MFCS 201
New sociotechnical insights in interaction design
New challenges are facing interaction design. On one hand because of advances in technology – pervasive, ubiquitous, multimodal and adaptive computing – are changing the nature of interaction. On the other, web 2.0, massive multiplayer games and collaboration software extends the boundaries of HCI to deal with interaction in settings of remote communication and collaboration. The aim of this workshop is to provide a forum for HCI practitioners and researchers interested in knowledge from the social sciences to discuss how sociotechnical insights can be used to inform interaction design, and more generally how social science methods and theories can help to enrich the conceptual framework of systems development and participatory design. Position papers submissions are invited to address key aspects of current research and practical case studies
High Ice Water Content at Low Radar Reflectivity near Deep Convection: Part II. Evaluation of Microphysical Pathways in Updraft Parcel Simulations
The aeronautics industry has established that a threat to aircraft is posed by atmospheric conditions of substantial ice water content (IWC) where equivalent radar reflectivity (Ze) does not exceed 20-30 dBZ and supercooled water is not present; these conditions are encountered almost exclusively in the vicinity of deep convection. Part 1 (Fridlind et al., 2015) of this two-part study presents in situ measurements of such conditions sampled by Airbus in three tropical regions, commonly near 11 km and -43 C, and concludes that the measured ice particle size distributions are broadly consistent with past literature with profiling radar measurements of Z(sub e) and mean Doppler velocity obtained within monsoonal deep convection in one of the regions sampled. In all three regions, the Airbus measurements generally indicate variable IWC that often exceeds 2 gm (exp -3) with relatively uniform mass median area-equivalent diameter (MMD(sub eq) of 200-300 micrometers. Here we use a parcel model with size-resolved microphysics to investigate microphysical pathways that could lead to such conditions. Our simulations indicate that homogeneous freezing of water drops produces a much smaller ice MMD(sub eq) than observed, and occurs only in the absence of hydrometeor gravitational collection for the conditions considered. Development of a mass mode of ice aloft that overlaps with the measurements requires a substantial source of small ice particles at temperatures of about -10 C or warmer, which subsequently grow from water vapor. One conceivable source in our simulation framework is Hallett-Mossop ice production; another is abundant concentrations of heterogeneous ice freezing nuclei acting together with copious shattering of water drops upon freezing. Regardless of the production mechanism, the dominant mass modal diameter of vapor-grown ice is reduced as the ice-multiplication source strength increases and as competition for water vapor increases. Both mass and modal diameter are reduced by entrainment and by increasing aerosol concentrations. Weaker updrafts lead to greater mass and larger modal diameters of vapor-grown ice, the opposite of expectations regarding lofting of larger ice particles in stronger updrafts. While stronger updrafts do loft more dense ice particles produced primarily by raindrop freezing, we find that weaker updrafts allow the warm rain process to reduce competition for diffusional growth of the less dense ice expected to persist in convective outflow
An L Band Spectrum of the Coldest Brown Dwarf
The coldest brown dwarf, WISE 0855, is the closest known planetary-mass,
free-floating object and has a temperature nearly as cold as the solar system
gas giants. Like Jupiter, it is predicted to have an atmosphere rich in
methane, water, and ammonia, with clouds of volatile ices. WISE 0855 is faint
at near-infrared wavelengths and emits almost all its energy in the
mid-infrared. Skemer et al. 2016 presented a spectrum of WISE 0855 from 4.5-5.1
micron (M band), revealing water vapor features. Here, we present a spectrum of
WISE 0855 in L band, from 3.4-4.14 micron. We present a set of atmosphere
models that include a range of compositions (metallicities and C/O ratios) and
water ice clouds. Methane absorption is clearly present in the spectrum. The
mid-infrared color can be better matched with a methane abundance that is
depleted relative to solar abundance. We find that there is evidence for water
ice clouds in the M band spectrum, and we find a lack of phosphine spectral
features in both the L and M band spectra. We suggest that a deep continuum
opacity source may be obscuring the near-infrared flux, possibly a deep
phosphorous-bearing cloud, ammonium dihyrogen phosphate. Observations of WISE
0855 provide critical constraints for cold planetary atmospheres, bridging the
temperature range between the long-studied solar system planets and accessible
exoplanets. JWST will soon revolutionize our understanding of cold brown dwarfs
with high-precision spectroscopy across the infrared, allowing us to study
their compositions and cloud properties, and to infer their atmospheric
dynamics and formation processes.Comment: 19 pages, 21 figures. Accepted for publication in Ap
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