Intellectual Property and the Prisoner’s Dilemma: A Game Theory Justification of Copyrights, Patents, and Trade Secrets

In this article, I will offer an argument for the protection of intellectual property based on individual self-interest and prudence. In large part, this argument will parallel considerations that arise in a prisoner’s dilemma game. In brief, allowing content to be unprotected in terms of free access leads to a sub-optimal outcome where creation and innovation are suppressed. Adopting the institutions of copyright, patent, and trade secret is one way to avoid these sub-optimal results

AnswerTree – a hyperplace-based game for collaborative mobile learning

In this paper we present AnswerTree, a collaborative mobile location-based educational game designed to teach 8-12 year olds about trees and wildlife within the University of Nottingham campus. The activity is designed around collecting virtual cards (similar in nature to the popular Top TrumpsTM games) containing graphics and information about notable trees. Each player begins by collecting one card from a game location, but then he or she can only collect further cards by answering questions – whose solutions are obtainable through sharing knowledge with other cardholders. This ostensibly allows each player to become a subject expert at the start of the game, encouraging collaborative interaction for the game to be successfully completed. In this initial paper we will outline the structure and background of this location based game. AnswerTree has been authored within the Hyperplace framework, and is a first implementation of a wider process to develop a flexible, multi-purpose platform for both individual and group location-based mobile learning

Applications of dynamic diffuse signal processing in sound reinforcement and reproduction.

Electroacoustic systems are subject to position-dependent frequency responses due to coherent interference between multiple sources and/or early reflections. Diffuse signal processing (DiSP) provides a mechanism for signal decorrelation to potentially alleviate this well-known issue in sound reinforcement and reproduction applications. Previous testing has indicated that DiSP provides reduced low-frequency spatial variance across wide audience areas, but in closed acoustic spaces is less effective due to coherent early reflections. In this paper, dynamic implementation of DiSP is examined, whereby the decorrelation algorithm varies over time, thus allowing for decorrelation between surface reflections and direct sounds. Potential applications of dynamic DiSP are explored in the context of sound reinforcement (subwoofers, stage monitoring) and sound reproduction (small-room low-frequency control, loudspeaker crossovers), with preliminary experimental results presented.N/

Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression

Paul A. Reynolds, PhD, is supported by the Melville Trust for the Care and cure of Cancer.We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear YAP compared to fibroblasts in the stroma of normal mucosa, with a median cell count of 35.4 per high-power field in the former and 3.9 in the latter. No differences were observed between the expression of YAP phosphorylated at Ser127 in the tumoral stroma compared to that in the normal mucosa, with a median cell count expression of 4.9 in the former versus 5.0 in the latter. Therefore, a strong and increased nuclear YAP expression in fibroblasts associated with perineural invasion in head and neck squamous cell carcinoma suggests that YAP-mediated transcription programs in these fibroblasts may contribute to perineural invasion.PostprintPublisher PDFPeer reviewe

Evaluative feedback can improve deductive reasoning

We examine whether reasoning is improved by evaluative feedback, i.e., the information of whether a reasoner’s answer was correct or incorrect, and report two studies that show that evaluative feedback increases the chances that participants will produce normatively correct responses for deductive reasoning problems. In Experiment 1, participants who were given feedback about their performance did better on problems based on disjunctions that were designed to elicit illusory inferences. In Experiment 2, participants answered difficult syllogisms with more accuracy when they were provided with feedback. We conclude by contrasting the rule-, heuristics-, and model-based accounts of deduction on their ability to explain the effects of evaluative feedback

Failure Analysis and Recovery of a 50-mm Highly Elastic Intermetallic NiTi Ball Bearing for an ISS Application

Ball bearings used inside the ISS Distillation Assembly centrifuge require superior corrosion and shock resistance to withstand acidic wastewater exposure and heavy spacecraft launch related loads. These requirements challenge conventional steel bearings and provide an ideal pathfinder application for 50-mm bore, deep-groove ball bearings made from the corrosion immune and highly elastic intermetallic material 60NiTi. During early ground testing in 2014 one 60NiTi bearing unexpectedly and catastrophically failed after operating for only 200 hr. A second bearing running on the same shaft was completely unaffected. An investigation into the root cause of the failure determined that an excessively tight press fit of the bearing outer race coupled with NiTi's relatively low elastic modulus were key contributing factors. The proposed failure mode was successfully replicated by experiment. To further corroborate the root cause theory, a successful bearing life test using improved installation practices (selective fitting) was conducted. The results show that NiTi bearings are suitable for space applications provided that care is taken to accommodate their unique material characteristics

Retinal Architecture in ​\u3cem\u3eRGS9-\u3c/em\u3e and ​\u3cem\u3eR9AP\u3c/em\u3e-Associated Retinal Dysfunction (Bradyopsia)

Purpose To characterize photoreceptor structure and mosaic integrity in subjects with RGS9- and R9AP-associated retinal dysfunction (bradyopsia) and compare to previous observations in other cone dysfunction disorders such as oligocone trichromacy. Design Observational case series. Methods setting: Moorfields Eye Hospital (United Kingdom) and Medical College Wisconsin (USA). study population: Six eyes of 3 subjects with disease-causing variants in RGS9 or R9AP. main outcome measures: Detailed retinal imaging using spectral-domain optical coherence tomography and confocal adaptive-optics scanning light ophthalmoscopy. Results Cone density at 100 μm from foveal center ranged from 123 132 cones/mm2to 140 013 cones/mm2. Cone density ranged from 30 573 to 34 876 cones/mm2 by 600 μm from center and from 15 987 to 16,253 cones/mm2 by 1400 μm from center, in keeping with data from normal subjects. Adaptive-optics imaging identified a small, focal hyporeflective lesion at the foveal center in both eyes of the subject with RGS9-associated disease, corresponding to a discrete outer retinal defect also observed on spectral-domain optical coherence tomography; however, the photoreceptor mosaic remained intact at all other observed eccentricities. Conclusions Bradyopsia and oligocone trichromacy share common clinical symptoms and cannot be discerned on standard clinical findings alone. Adaptive-optics imaging previously demonstrated a sparse mosaic of normal wave-guiding cones remaining at the fovea, with no visible structure outside the central fovea in oligocone trichromacy. In contrast, the subjects presented in this study with molecularly confirmed bradyopsia had a relatively intact and structurally normal photoreceptor mosaic, allowing the distinction between these disorders based on the cellular phenotype and suggesting different pathomechanisms

Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling

Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with inflammation is limited. This may be particularly so in the case of granulomatous inflammation, where an excessive number and / or excessively florid granulomas can have significant pathological consequences. Here, we have combined transcriptomics, agent-based modeling and in vivo experimental approaches to study constraints on hepatic granuloma formation in a murine model of experimental leishmaniasis. We demonstrate that chemokine production by non-infected Kupffer cells in the Leishmania donovani-infected liver promotes competition with infected KCs for available iNKT cells, ultimately inhibiting the extent of granulomatous inflammation. We propose trans-activation for chemokine production as a novel broadly applicable mechanism that may operate early in infection to limit excessive focal inflammation