Current perspectives on skeletal health and cancer progression across the disease continuum in breast cancer—The role of bisphosphonates

Pre-clinical and clinical evidence suggest that bisphosphonates inhibit both bone resorption and cancer progression. New and updated analyses from several large, controlled studies in pre- and post-menopausal women with early stage breast cancer (BC) suggest that addition of bisphosphonates improves cancer-related outcomes, particularly in patients with a ‘low-estrogen environment’. Further, preliminary clinical data suggest that bisphosphonate therapy may reduce circulating tumour cell numbers (a negative prognostic indicator of disease-free and overall survival) in patients with advanced/metastatic disease. These new findings warrant reconsideration of the therapeutic role of bisphosphonates in BC

Effective elastic properties for lower limb soft tissues from manual indentation experiment

Rehabilitation Engineering CentreVersion of RecordPublishe

An ultrasound indentation system for biomechanical properties assessment of soft tissues in-vivo

Rehabilitation Engineering CentreVersion of RecordPublishe

Fast label-free multilayered histology-like imaging of human breast cancer by photoacoustic microscopy

The goal of breast-conserving surgery is to completely remove all of the cancer. Currently, no intraoperative tools can microscopically analyze the entire lumpectomy specimen, which results in 20 to 60% of patients undergoing second surgeries to achieve clear margins. To address this critical need, we have laid the foundation for the development of a device that could allow accurate intraoperative margin assessment. We demonstrate that by taking advantage of the intrinsic optical contrast of breast tissue, photoacoustic microscopy (PAM) can achieve multilayered histology-like imaging of the tissue surface. The high correlation of the PAM images to the conventional histologic images allows rapid computations of diagnostic features such as nuclear size and packing density, potentially identifying small clusters of cancer cells. Because PAM does not require tissue processing or staining, it can be performed promptly and intraoperatively, enabling immediate directed re-excision and reducing the number of second surgeries

Biomechanics of pressure ulcer in body tissues interacting with external forces during locomotion

2009-2010 > Academic research: refereed > Publication in refereed journalAuthor’s OriginalPublishe

An ultrasonic measurement for in vitro depth-dependent equilibrium strains of articular cartilage in compression

Author name used in this publication: Y. P. ZhengAuthor name used in this publication: A. F. T. MakJockey Club Rehabilitation Engineering Centre2002-2003 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Reliability of measurement of skin ultrasonic properties in vivo : a potential technique for assessing irradiated skin

Author name used in this publication: Y. P. HuangAuthor name used in this publication: Y. P. ZhengAuthor name used in this publication: A. F. T. MakAuthor name used in this publication: S. F. Leung2006-2007 > Academic research: refereed > Publication in refereed journalAuthor’s OriginalPublishe

Biomechanical assessment of plantar foot tissue in diabetic patients using an ultrasound indentation system

Author name used in this publication: Y. P. ZhengRehabilitation Engineering Centre2000-2001 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe