MEDIA PASINAON VIDEO TUTORIAL LANCARAN MAYAR SEWU LAN GUGUR GUNUNG BERBASIS WEB KANGGE MAHASISWA PENDIDIKAN BAHASA DAERAH FAKULTAS BAHASA DAN SENI UNIVERSITAS NEGERI YOGYAKARTA

Ancasing panaliten menika, inggih menika: (1) ngandharaken tahap-tahap damel media pasinaon Video Tutorial Lancaran Manyar Sewu Lan Lancaran Gugur Gunung Berbasis Web Kangge Mahasiswa Pendidikan Bahasa Daerah Fakultas Bahasa Dan Seni Universitas Negeri Yogyakarta; (2) ngandharaken kualitas media pasinaon Video Tutorial Lancaran Manyar Sewu Lan Lancaran Gugur Gunung Berbasis Web Kangge Mahasiswa Pendidikan Bahasa Daerah Fakultas Bahasa Dan Seni Universitas Negeri Yogyakarta dening dosen ahli materi saha dosen ahli media; (3) ngandharaken pamanggihipun Dosen Basa Jawi sarta Mahasiswa babagan media pasinaon Video Tutorial Lancaran Manyar Sewu Lan Lancaran Gugur Gunung Berbasis Web babagan penyajian materi saha tampilan produk. Panaliten menika kalebet jinis panaliten Research and Development (R&D). Kanthi tahap analysis, design, development, implementation, sarta evaluation. Produk media menika dipunevaluasi dening dosen ahli materi saha dosen ahli media mawi validasi dumugi pikantuk kualitas media ingkang sae saha layak dipunuji coba wonten ing sekolah. Asiling panaliten nedahaken bilih cak-cakanipun damel media pasinaon kaperang dados gangsal tataran. Tataran ingkang sepisan inggih menika analisis kurikulum, kabetahan Mahasiswa, saha wawancara Dosen. Tataran kaping kalih inggih menika damel design media pasinaon kanthi ngempalaken referensi saha damel Bagan saha Planning Materi. Tataran kaping tiga inggih menika nyuwun validasi dening dosen ahli materi saha dosen ahli media dumugi pikantuk pasarujukan kangge uji coba. Tataran kaping sekawan inggih menika uji coba media pasinaon dhateng sekolah. Tataran kaping gangsal evaluasi media pasinaon. Wondene kualitas media saking dosen ahli materi pikantuk rata-rata presentase biji 82% ingkang kagolong sae sanget. Pambiji kualitas media dening dosen ahlli media pikantuk rata-rata presentase biji 88% ingkang kagolong sae sanget. Wondene pamanggih Dosen Basa Jawi ngengingi leresipun konsep saha kompetensi saha kualitas tampilan media menika pikantuk rata-rata presentase 96% ingkang kagolong sae sanget. Asiling angket pamanggih Mahasiswa tumrap panganggenipun media pasinaon menika saged narik kawigatosan Mahasiswa

Analisis Tata Kelola Seni Pertunjukan di Taman Budaya Yogyakarta

Pandemik covid-19 berdampak besar terhadap penyelenggaraan seni pertunjukan di Taman Budaya Yogyakarta. Penelitian ini bertujuan untuk mendeskripsikan tata kelola seni pertunjukan di Taman Budaya Yogyakarta pada masa pandemik covid-19. Penelitian ini merupakan penelitian deskriptif kualitatif fenomenologi. Sasaran penelitian adalah UPT Taman Budaya Yogyakarta. Informan terdiri dari enam orang yaitu Kepala UPT, Seksi Penyajian dan Pengembangan Seni Budaya, Seksi Dokumentasi dan Informasi Seni Budaya, serta tiga seniman. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Analisis data menggunakan analisis deskriptif dengan cara reduksi data, penyajian data, penarikan kesimpulan/verifikasi. Hasil penelitian pada Perencanaan mengacu program dari pemerintah daerah sebagai kegiatan rutin, ditambah dengan pertunjukan melalui seleksi proposal dari masyarakat, penyusunan program dengan adaptasi kebutuhan media pada masa pandemik covid-19. Pengorganisasian dan Pengawasan dilaksanakan sesuai dengan perencanaan, pola hubungan dilaksanakan secara kerja sama lintas seksi sesuai dengan tugas dan fungsi. Pengawasan di bawah seksi bidang penyajian dan pengembangan seni budaya serta seksi bidang dokumentasi dan publikasi. Beberapa hambatan ditemukan mulai dari peralatan, serta keterbatasan SDM. Evaluasi dilakukan setiap program berjalan, laporan langsung kepada Kepala Taman Budaya Yogyakarta dalam bentuk LPJ. Tindak lanjut berupa pengembangan inovasi program seperti peralatan daring bekerja sama dengan pihak luar dan inovasi program kepada kalangan disabilitas walaupun masih banyak keterbatasan. Analysis of Governance in the Performing Arts Culture Yogyakarta ABSTRACT The covid-19 pandemic has significantly impacted the implementation of performing arts at Taman Budaya Yogyakarta. This study aims to describe the governance of performing arts in Taman Budaya Yogyakarta during the covid-19 pandemic. This research is a qualitative descriptive research of phenomenology. The target of the study was UPT Taman Budaya Yogyakarta. The informants comprised six: the Head of UPT, the Cultural Arts Presentation and Development Section, the Cultural Arts Documentation and Information Section, and three artists. Data collection techniques use observation, interview, and documentation techniques. Data analysis uses descriptive data reduction, presentation, and concluding/verification. The results of this research are on Planning to refer to programs from local governments as routine activities, coupled with performances through the selection of proposals from the community and preparation of programs adapting to media needs during the covid-19 pandemic. Organizing and supervision are carried out by planning, and the pattern of relationships is carried out in cross-sectional cooperation following duties and functions, supervised under the section in the field of presentation and development of cultural arts and the section in the field of documentation and publications. Several obstacles were found, ranging from equipment to limited human resources. Evaluation is carried out every running program, a direct report to the head of Taman Budaya Yogyakarta in the form of LPJ. Follow-up is in the form of developing program innovations such as online equipment in collaboration with outside parties and program innovations for people with disabilities, although there are still many limitations

Mobility-shift-Affinitätskapillarelektrophorese zur Untersuchung von Protein-Metallionen-Wechselwirkungen: Aspekte der Methodenentwicklung, -validierung und des High-Throughput-Screenings

Approximately one third of all proteins are metalloproteins, which means the metal ions are important for their biological functions. Therefore, investigation and characterization of interactions between proteins and metal ions are interesting. Several techniques can be used for these purposes. Mobility shift-affinity capillary electrophoresis has been selected over the other techniques due to its rapid analysis, small injection volume (nano-level), high separation efficiency, direct injection of impure samples and the ability to perform under physiological-like conditions. In order to facilitate the implementation of a mobility shift-affinity capillary electrophoresis method into routine binding studies, method acceleration, transfer and precision improvement were investigated. The mobility shift-affinity capillary electrophoresis method was successfully accelerated by using shorter capillaries, lower sample concentrations and smaller injection volumes. Fast run time of 4 min has been achieved. The precision of results was enhanced by slightly pushing the sample into the capillary, refreshing the buffer vials after each 30 runs and employing extra flushing after each 60 subsequent runs and using 0.1 M EDTA within the rinsing protocols. The accelerated mobility shift-affinity capillary electrophoresis method has been successfully applied for the interaction study of Li+, Na+, Mg2+, Ca2+, Ba2+, Al3+, Ga3+, La3+, Pd2+, Ir3+, Ru3+, Rh3+, Pt2+, Pt4+, Os3+, Au3+, Au+, Ag+, Cu+, Cu2+, Fe2+, Fe3+, Co2+, Ni2+, Cr3+, V3+, MoO42- and SeO32- with bovine serum albumin, β-lactoglobulin, human serum albumin, myoglobin and ovalbumin. Excellent precision for mobility ratios was achieved for all protein-metal ion interactions (RSD% of 0.05-1.0%, n > 324). The calculated normalized difference of mobility ratio and its sign (positive and negative) for each protein-metal ion interaction have been successfully used to detect the interaction and estimate further coordination of the bound metal ion, respectively. Furthermore, the results were successfully discussed in view of the properties of the metal ions and proteins, and the HSAB concept as well. The comprehensive platform summarizes all the obtained interaction results, and is valuable for any future protein-metal ion investigation.Schätzungsweise ein Drittel aller Proteine sind Metalloproteine, dies bedeutet, dass Metallionen für ihre biologische Funktion von Bedeutung sind. Somit ist die Untersuchung und Charakterisierung der Wechselwirkungen zwischen Proteinen und Metallionen von Interesse. Einige Techniken können für diesen Zweck verwendet werden. Der Mobility-shift-Affinitätskapillarelektrophorese wurde gegenüber anderen Techniken der Vorzug gegeben, da sie kurze Analysenzeiten, Injektionen von geringen Probenvolumina (im Nanoliterbereich), hohe Trennungseffizienz, direkte Injektion von nicht aufgearbeitet Proben und die Möglichkeit unter physiologischen Bedingungen zu arbeiten vereint. Um das Einbinden einer Mobility-shift-Affinitätskapillarelektrophoresemethode in Routinebindungsstudien zu erleichtern, wurden eine Verkürzung der Analysendauer, der Methodentransfer und die Verbesserung der Präzision untersucht. Die Mobility-shift-Affinitätskapillarelektrophoresemethode wurde erfolgreich beschleunigt durch Verkürzen der Kapillare, Verwenden geringerer Probenkonzentrationen und geringerer Probenvolumina. Hierbei wurden kurze Analysezeiten von 4 Minuten erreicht. Die Präzision der Ergebnisse wurden durch ein leichtes Drücken der Probe in die Kapillare nach der Injektion, das Tauschen der Puffergefäße nach 30 Läufen, Einführen eines weiteren Spülschrittes nach 60 aufeinanderfolgenden Läufen und Verwendung von 0.1 M EDTA-Lösungen im Spülprotokoll verbessert. Diese verbesserte Mobility-shift-Affinitätskapillarelektrophoresemethode wurde erfolgreich verwendet um Interaktionsstudien zwischen Li+, Na+, Mg2+, Ca2+, Ba2+, Al3+, Ga3+, La3+, Pd2+, Ir3+, Ru3+, Rh3+, Pt2+, Pt4+, Os3+, Au3+, Au+, Ag+, Cu+, Cu2+, Fe2+, Fe3+, Co2+, Ni2+, Cr3+, V3+, MoO42- und SeO32- mit bovinem Serumalbumin, β-Lactoglobulin, humanem Serumalbumin, Myoglobin und Ovalbumin. Ausgezeichnete Präzision wurde für den Mobilitätsquotienten jeder Protein-Metallionen-Interaktion (RSD% von 0,05-1,0%, n > 324). Die berechnete, normalisierte Differenz der Mobilitätsquotienten und deren Vorzeichen (positiv und negativ) jeder Protein-Metalionen-Interaktion konnten erfolgreich verwendet werden um Interaktionen zu erkennen und die weitere Koordination der Metallionen abzuschätzen. Des Weiteren konnten die Ergebnisse in Hinblick auf die Eigenschaften der Metallionen und Proteine sowie des HSAB-Konzepts erfolgreich diskutiert werden. Die Gesamtübersicht fasst alle erhaltenen Interaktionsergebnisse zusammen und ist wertvoll für zukünftige Protein-Metallionenuntersuchungen

Bacterial Infection Among Covid-19-Infected Patients Admitted to the Intensive Care Unit at King Abdullah Hospital in Bisha: A Single-Centre Retrospective Observational Study

Background: The covid-19 pandemic has created significant challenges for healthcare systems worldwide, especially in intensive care units (ICU), which face unprecedented hardship. Despite the primary focus on viral infection, the precise influence of bacterial superinfections on the outcome of severe covid-19 cases, particularly in different hospital settings, remains uncertain. Objective: to investigate the prevalence, characteristics, and outcomes of bacterial superinfections in covid-19 patients hospitalized in the ICU in Saudi Arabia during the second wave of the pandemic. Methods: This study was conducted at King Abdullah Hospital in Bisha, Saudi Arabia, and involved retrospective observational analysis. This study examined 121 adult patients admitted to the ICU due to severe covid-19 between April and July 2021. Information regarding demographics, clinical characteristics, radiological findings, and microbiological data was also collected. This study examined the relationship between superinfections and mortality through rigorous statistical analyses, including chi-square testing and multivariable logistic regression. Results: Most participants in the study were men (57.9%) and Saudi citizens (95.0%), with an average age of 63 ± 17 years. The incidence of superinfections among the patients was 43.8%, significantly higher than that reported in previous studies. Microbiological examinations revealed the presence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) organisms, particularly in respiratory samples. The most common isolates were KLEPNE-XDR (10.7%) and ACIBAU-XDR (8.3%). A statistically significant correlation was observed between superinfection and mortality (p=0.042). Patients with superinfections experienced a significantly higher mortality rate of 55.3% in comparison to those without superinfections, who had a mortality rate of 44.7%. Multivariable logistic regression identified age (aOR 1.040, 95% CI: 1.012-1.068, p=0.004) and non-Saudi nationality (aOR 12.320, 95% CI: 1.242-122.177, p=0.032) as significant predictors of mortality. Interestingly, a high percentage of the patients (89.3 %) were treated with carbapenems. Conclusion: Our research revealed a notable prevalence of bacterial superinfections, including highly resistant strains, among severely ill covid-19 patients in the ICU. The significant link between superinfections and mortality underscores the pressing need for enhanced diagnostic tools, targeted antimicrobial therapies, and improved stewardship protocols in the ICU setting. The findings of this study have important implications for clinical care and public health policy in the ongoing battle against covid-19 and its consequences

Osteopontin as a marker for response to pegylated interferon Alpha-2b treatment in Chronic HCV Saudi patients

Background: Many recent studies support the idea that osteopontin (OPN) can be used to predict the success of pegylated interferon (PEG IFN) alpha-2b/ribavirin therapy in chronic HCV patients.Objective: Our aim was to investigate the role of plasma OPN and its gene polymorphism at nt – 443 in response to PEG IFN in Saudi patients with chronic HCV.Methods: Blood was collected from 87 patients with chronic hepatitis C before treatment, then patients received PEG IFN α2b plus ribavirin combination therapy. Another 25 healthy subjects, matched for age and sex to patients, were enrolled as controls. Single nucleotide polymorphism (SNP) in OPN at nt – 443 and its blood level were analyzed.Results: The frequency of patients who reached sustained virological response (SVR) was increased in patients with T/T at nt – 443 than in those with C/C or C/T. Also the frequency of T allele was increased in responders than in non-responders. However, this increase was not statistically significant. The blood level of OPN was significantly increased in non-responders (Mean±SD=37.21±3.9) in comparison to responders (Mean±SD=33.22±4.1).Conclusion: Osteopontin blood level can be considered as a reliable predictor to PEG IFN α2b plus ribavirin therapy in chronic HCV Saudi Patients.Keywords: OPN, PEG IFN, HCV, SVR, SNP, RT-PC

Access-Point to Access-Point Connectivity for PON-based OWC Spine and Leaf Data Centre Architecture

In this paper, we propose incorporating Optical Wireless Communication (OWC) and Passive Optical Network (PON) technologies into next generation spine-and-leaf Data Centre Networks (DCNs). In this work, OWC systems are used to connect the Data Centre (DC) racks through Wavelength Division Multiplexing (WDM) Infrared (IR) transceivers. The transceivers are placed on top of the racks and at distributed Access Points (APs) in the ceiling. Each transceiver on a rack is connected to a leaf switch that connects the servers within the rack. We replace the spine switches by Optical Line Terminal (OLT) and Network Interface Cards (NIC) in the APs to achieve the desired connectivity. We benchmark the power consumption of the proposed OWC-PON-based spine-and-leaf DC against traditional spine-and-leaf DC and report 46% reduction in the power consumption when considering eight racks

A comprehensive overview of selective and novel fibroblast growth factor receptor inhibitors as a potential anticancer modality

The arrival of comprehensive genome sequencing has accelerated the understanding of genetically aberrant advanced cancers and target identification for possible cancer treatment. Fibroblast growth factor receptor (FGFR) gene alterations are frequent findings in various rare and advanced cancers refractive to mainstay chemotherapy or surgical interventions. Several FGFR inhibitors have been developed for addressing these genetically altered FGFR-harboring malignancies, and some have performed well in clinical trials. In contrast, others are still being investigated in different phases of clinical trials. FDA has approved four anticancer agents such as erdafitinib, pemigatinib, infigratinib, and futibatinib, for clinical use in oncogenic FGFR-driven malignancies. These include cholangiocarcinoma, urothelial carcinoma, and myeloid/lymphoid malignancies. Pemigatinib is the only FGFR inhibitor globally approved (USA, EU, and Japan) and available as a targeted therapy for two types of cancer, including FGFR2 fusion or other rearrangements harboring cholangiocarcinoma and relapsed/refractory myeloid/lymphoid neoplasms with FGFR1 rearrangements. Myeloid/lymphoid neoplasm is the latest area of application added to the therapeutic armamentarium of FGFR inhibitors. Furthermore, futibatinib is the first-in-class covalent or irreversible pan-FGFR inhibitor that has received FDA approval for locally advanced or metastatic intrahepatic cholangiocarcinoma harboring FGFR2 gene aberrations. This review highlights the current clinical progress concerning the safety and efficacy of all the approved FGFR-TKIs (tyrosine kinase inhibitors) and their ongoing investigations in clinical trials for other oncogenic FGFR-driven malignancies

Patients’ Perception on Clinical Training and Informed Consent Towards Medical Students in Jazan Hospitals: A Cross-Sectional Study

Background: Bedside teaching offers many advantages for medical education. When real patients are involved in the clinical practice, teaching medicine often involves difficult ethical dilemmas so it must be precisely detected and properly dealt with. Objective: to evaluate patients' perspectives on clinical training and informed consent within teaching hospitals in Jazan. Method: This cross-sectional observational study targeted all adult who previously met a medical student. A self-administered questionnaire to assess the patient’s perspective on clinical training and informed consent towards medical students were answered by the participants. T-tests and chi-square tests, along with multiple logistic regression, were used for analysis. Results: 200 participants were selected for this study with a mean age of 32.52 years. 51.3% of the participants were female, and 55.3% of the participants were married. 59.6% of the patients reported that the doctor asked for their permission for the student to be present. Only 31.1 % stated that they felt uncomfortable and 70% of the participants reported that they received more explanation about their illness when medical students were present. Almost all patients felt pleased that they had contributed to the students’ medical education. Conclusion: The research has demonstrated that patients' acceptability of medical students appeared to be influenced by the nature of the interaction between the patient and the student, the education level, and the student-patient gender. In general, most patients were pleased that they were able to help in the students' medical education. In order to enhance the learning process for medical students, clinical tutors must benefit from patients who accept medical students