Beneficial role of allicin from garlic in cervical cancer

Introduction: Cervical cancer remains a global health concern for females. Thus, in order to control cervical cancer, attempts are being made by researchers globally to somehow induce programmed cell death in the said cancerous cells. Wide spectrums of molecules are being probed for its ability to induce apoptosis in cervical cancer cells. Focus has now shifted in exploring natural compounds having antioxidant and anti-inflammatory molecules that may induce apoptosis in cancerous cells. Thus, we have employed allicin from garlic- a natural antioxidant, to probe the above in the present study.
Objective: To probe whether or not allicin from garlic, a natural antioxidant, induces apoptosis in monocytes from patients with cervical cancer.
Results: Allicin (500 ng/ml) reduced cell viability to 27% after 24 hours of treatment. Moreover, allicin-induced apoptosis was ascertained by measuring the activity of caspase-3, caspase-8 and caspase-9-like proteases in allicin treated and untreated monocytes from cervical cancer patients. Monocyte co-cultured with allicin for 24 hrs exhibited higher activity of caspase-3 followed by caspase-8 and caspase-9 like proteases, thereby indicating that the activation of caspase-3 like proteases was associated with reduced cell survival and apoptotic death of allicin-treated cervical cancer monocytes. This was ascertained by pre-treatment of cancer cells with cell permeable inhibitor Z-VAD-FMK (caspase-3 inhibitor), Z-IETD-FMK (caspase-8 inhibitor) and Z-LEHD-FMK (caspase-9 inhibitor) followed by allicin for 24 hrs (p<0.001). In this case, the cell viability assay showed that the presence of Z-VAD-FMK inhibitor blocked the effect of allicin on the viability of cancer monocytes (p<0.001).
Conclusion: Allicin from garlic may act as an adjunct in the chemotherapy of cervical cancer.
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Soil quality assessment in difference vegetation structures of Surajpur lake: An urban wetland of Upper Gangetic plain, Northern India

Surajpur Lake is the prominent wetland site in National Capital Region, India known for its rich avifaunal and other aquatic biodiversity. Present study was carried out to assess the soil quality in different vegetation structures in Surajpur wetland from March 2010 to February 2013. Soil Sampling was conducted in five different vegetation habitats in the study area by applying standard sampling protocols. A total of 9 Physical and 16 chemical parameters were selected for analysis. The overall means of physical parameters of soil sample includes soil moisture content 11.17 ± 3.03 %, bulk density 1.19 ± 0.01 gm/ml, porosity 35.00 ± 5.10 %, water holding capacity 35.00 ± 3.86 %, soil organic carbon 0.09 ± 0.05 %, electrical conductivity 276.42 ± 112.83 ds/m, pH value 9.98 ± 0.42 was recorded. The means of chemical parameters of soil sample includes total Kjeldahl nitrogen 286.76 ± 42.41 mg/kg, available phosphorus 338.50 ± 32.75 mg/kg, potassium 2.85 ± 0.39 mg/kg, calcium level 10.86 ± 6 73 mg/kg, magnesium 10.56 ± 4.43 mg/kg, iron 14.90 ± 1.99 mg/kg, manganese 289.13 ± 42.89 mg/kg, zinc 4.20 ± 0.45 mg/kg, chloride 223.73 ± 62.64 mg/kg, sulphate 150.21 ± 27.99 mg/kg and silica oxide 7.97 ± 1.45 mg/kg. Boron, Copper and Molybdenum nutrients recorded less than one mg/kg in the soil sample. The viable count of bacteria recorded an overall mean of 16,56,000.00 ± 11,06,157.31 cfu/g. The results indicated that the essential mineral nutrients are widely distributed in the soil and are pollution free and also no any organic waste is coming to the site. Soil is good enough to support rich biodiversity to form a complete food web in the Surajpur wetland ecosystem

Retrospective Cost Adaptive Control of Generic Transport Model Under Uncertainty and Failure

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143070/1/1.I010454.pd

Wobbling motion in the multi-bands crossing region

The backbending in the A=180 mass region is expected to be caused by multi-bands crossing between low-K (g- and s-bands) and high-K bands. % We analyze a mechanism of coupling of these bands in terms of a dynamical treatment for nuclear rotations, i.e., the wobbling motion. The wobbling states are produced through the generator coordinate method after angular momentum projection, in which the intrinsic states are constructed through the 2d-cranked HFB calculations.Comment: 9 pages, 3 PS figures: to appear in Phys.Lett.

Iris segmentation

The quality of eye image data become degraded particularly when the image is taken in the non-cooperative acquisition environment such as under visible wavelength illumination. Consequently, this environmental condition may lead to noisy eye images, incorrect localization of limbic and pupillary boundaries and eventually degrade the performance of iris recognition system. Hence, this study has compared several segmentation methods to address the abovementioned issues. The results show that Circular Hough transform method is the best segmentation method with the best overall accuracy, error rate and decidability index that more tolerant to ‘noise’ such as reflection

Geological dimension of the cultural heritage: A case example of the Ajanta Caves (Maharashtra, India)

[Abstract]International development for the both geoconservation and geotourism requires attention to all kinds of (potential) geological heritage. The Ajanta Caves (western Maharashtra, India) is a famous cultural object consisting of 30 caves carved in the Deccan Traps and inscribed to the UNESCO list of the World Heritage Sites. Its examination permits to indicate four geological features, which are the artificial caves themselves (these mark geological activity of the man in the historical past), the end-Cretaceous flood basalts (these demonstrate the emplacement of Large Igneous Province and the relevant palaeoenvironmental catastrophe), the gorge of the Waghora River (this is peculiar landform resulted from the river erosion of hard rocks), and the rockfall hazard (this is an interesting engineering geological phenomenon linked to the caves construction/maintenance). Geological heritage value of these features is argued. Unfortunately, there is not any geotourism activity at the Ajanta Caves presently. The content analysis of the principal on-line resources (web pages) devoted to this cultural site reveals the absence of sufficient geological information that would 68 Gontareva, E.F et al. CAD. LAB. XEOL. LAXE 38 (2015) facilitate geotourism. Generally, judgements about the Ajanta Caves and the other similar sites in the geological dimension permit to consider the wide spectrum of the geological heritage. They also highlight some extra opportunities for geotourism, which can benefit by its development at cultural sites with thousands of visitors