Synthesis of novel proponohydrazides and their hydrolysis reactions

4-(4-Methoxybenzoyl)-5-(4-methoxyphenyl)-2,3-furandione 1 reacted with N-aryl substituted phenyl-hydrazones 3a-h via the p,p'-dimethoxydibenzoylketene intermediate 2 giving the proponohydrazide derivatives 5a-h. In addition, compounds 5a-h were converted into corresponding pyrazolone derivatives 7i,j by the reactions of hydrolysis in acidic solution. The structures of these new synthesized compounds were determined by C-13 NMR, H-1 NMR and IR spectroscopic data and elemental analysis

Reactions of cyclic oxalyl compounds, synthesis of functionalized hydrazono-2H-imidazol-4,5(1H, 3H)dione: Experimental data and AMI calculations

The reaction of the 4-benzoyl-5-phenylfuran-2,3-dione (1) with guanylhydrones, (2a-d) gives hydrazono-2H-imidazol-4.5-(1H,3H)-dione derivatives (4a-d) (yield ca. 30-40%). The structure of these compounds were determined by spectroscopic methods. Quantum chemical calculations were carried out for 2a-d and 4a-d by AM I method

Synthesis of some pyrazole-3-carboxylic acid-hydrazide and pyrazolopyridazine compounds

Furan-2,3-diones la-c react with various hydrazines 2a-c under different conditions to yield the pyrazole-3-carboxylic acid-hydrazide 3a-d. Cyclocondensation reactions of la or 7 with phenylhydrazine lead to derivatives of pyrazolo[3,4-d]pyridazinones 6 and 8, respectively. The structures of all products were confirmed by elemental analysis, IR, H-1- and C-13-NMR spectroscopic measurements

Synthesis of new 2,3-dihydrofuran-3-one derivative and its reactions with some primary amines

The Wittig reaction of 2,3-dihydro-4-(4-methoxybenzoyl)-5-(4-methoxyphenyl)-furan-2,3-dione (1) with methyl (triphenylphosphoranylidene)acetate (2) stereo- and regioselectively afforded methyl (Z)-[2,3-dihydro-4-(4-methoxybenzoyl)-5 - (4-methoxyphenyl) - 3 -oxofuran-2-ylidene]acetate (3) in good yield. The reactions of 3 with primary amines (4a-k) gave corresponding 1-substituted 2,3 -dihydro-1H-pyrrol-3 -ones (5a-k)