A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies.

Control of organellar assembly and function is critical to eukaryotic homeostasis and survival. Gle1 is a highly conserved regulator of RNA-dependent DEAD-box ATPase proteins, with critical roles in both mRNA export and translation. In addition to its well-defined interaction with nuclear pore complexes, here we find that Gle1 is enriched at the centrosome and basal body. Gle1 assembles into the toroid-shaped pericentriolar material around the mother centriole. Reduced Gle1 levels are correlated with decreased pericentrin localization at the centrosome and microtubule organization defects. Of importance, these alterations in centrosome integrity do not result from loss of mRNA export. Examination of the Kupffer's vesicle in Gle1-depleted zebrafish revealed compromised ciliary beating and developmental defects. We propose that Gle1 assembly into the pericentriolar material positions the DEAD-box protein regulator to function in localized mRNA metabolism required for proper centrosome function

RanBP2/Nup358 Potentiates the Translation of a Subset of mRNAs Encoding Secretory Proteins

In higher eukaryotes, most mRNAs that encode secreted or membrane-bound proteins contain elements that promote an alternative mRNA nuclear export (ALREX) pathway. Here we report that ALREX-promoting elements also potentiate translation in the presence of upstream nuclear factors. These RNA elements interact directly with, and likely co-evolved with, the zinc finger repeats of RanBP2/Nup358, which is present on the cytoplasmic face of the nuclear pore. Finally we show that RanBP2/Nup358 is not only required for the stimulation of translation by ALREX-promoting elements, but is also required for the efficient global synthesis of proteins targeted to the endoplasmic reticulum (ER) and likely the mitochondria. Thus upon the completion of export, mRNAs containing ALREX-elements likely interact with RanBP2/Nup358, and this step is required for the efficient translation of these mRNAs in the cytoplasm. ALREX-elements thus act as nucleotide platforms to coordinate various steps of post-transcriptional regulation for the majority of mRNAs that encode secreted proteins

The impact of an educational course for swimming on free style swimming performance and life skills for deaf students

This study investigates the impact of an educational course for swimming on free style swimming performance and life skills for deaf students. Subjects were (10) male deaf students who were at-tended to swimming courses level (1) in the Faculty of Physical Education at the University of Jordan, with mean age of (M age = 20.4 SD =1.35). After completing the Life skills through swimming context scale (Bayyat et al., 2016) and practical pre-test of free style swimming skills performance, subjects executed both physical practice of the free style swimming skills performance during a pro-gram conceited of eighteen sessions, 3 sessions a week, for 6-weeks, 60 mints per session, and life skills development dialogues program which focused on certain life skills (Communications, team-work, self-confidence/self-Esteem, problem solving and decision-making/responsibility).After 6-weeks all subjects completed a post life skills questionnaire which measured the changes in their life skills level after learning the free style swimming skills performance, they also went through a post practical subjective performance evaluation post-test which measured their level of the free style swimming skills performance. Statistical analysis was processed by SPSS. The results showed significant differences between pre and post-test in life skills dimensions and significant differences between pre and post-test in free style swimming performance level for the subject of this study. In conclusions the educational course for swimming had a positive impact on free style swimming performance and on life skills for deaf students in the faculty of physical education at the University of Jordan

The Adequacy of Civil Protection for the Programs of Information Technology Organization in Jordanian law (Comparative Study)

The theme of this study is the adequacy of civil protection programs for information technology systems a comparative study between the position of the Jordanian legislator, Egyptian and other Arab legislations and the position of Jurisprudence from this protection under the law of copyright protection. Demonstrated through this research that there are a number of directions to protect information technology systems, first trend is: The first is: to provide protection for these programs under the protection of copyright law, and has two aspects, namely: The first side subjecting Information Technology systems software for copyright protection and the second side is: judicial and legislative opinion. There is a trend settle for traditional texts where this protection has adopted some of the relevant government departments implement copyright laws in this direction. However, most countries have become tend to modify existing legislation to include information technology systems. As for the Jordanian legislator attitude has been empty for a long period of a law to protect copyright, even the voices rose that advocated and demanded for the Jordanian legislation to do enact a law for the protection of copyright. Then the Copyright Protection Law No. (22) for the year (1992) was issued, which put the protection of literary works, and this law was including the protection of Information Technology systems from the outset text explicitly states in Article III in the second paragraph and eighth item of this paragraph

Effect of 17β Estradiol & Foot Strike Patterns on Physiological & Biomechanical Changes in Runners

It is well established that female runners are at a significantly increased risk of incurring injuries when compared to their male counterparts. Gender-specific factors such as anatomical, hormonal, and altered neuromuscular activation patterns have been implicated as causative factors. An association have been observed between hormonal fluctuation and ACL injury risk indicating potentially hormonal effect on both passive and dynamic knee stabilizer. A growing contingency believes that we were designed with all we need in our feet to be able to run with minimal shoes that mimic barefoot running striking pattern. Habitual barefoot runners tend to FFS, compared to habitually shod populations who tend to RFS. Reduced collision forces generated with FFS patterns relative to RFS account for the reduced injuries. The purpose of this study was to assess the effect of 6 weeks of a transition program of SBR on the pattern of muscle activation, spatiotemporal variables, and stance phase kinetics. These running parameters were compared and contrasted during the menstrual cycle to assess whether estrogen fluctuation has an effect on the pattern of muscle activation, and laxness of ACL. Twenty four females runner were divided into two groups. First group was tested twice across a menstrual cycle for serum levels of E, KJL and EMG activity of the quadriceps and hamstrings muscles. Second group gradually experienced SBR over 6 weeks. Kinetic analysis of running was performed during shod running, habituated SBR conditions. The results showed an observed increased in KJL in response to peak E during the ovulatory phase, which was associated with increased preactivity of the hamstring muscle. A consistent pattern was observed in the firing of the quadriceps muscle recruitment pattern throughout the follicular phase. The results of the second group indicated a significant decrease in the EMG activity of TA in the habituated SBR. A significant increase was observed in the preactivation of GAS between shod running, and habituated SBR. In conclusion, changes in KJL in response to 17β-Estradiol fluctuations changes the neuromuscular control around the knee. Changes in motor patterns in previously habitually shod runners are possible and can be accomplished within 6 weeks

The Level of Feeling of Guilt among Gifted Students in a Jordanian Sample at King Abdullah II Schools for Excellence

The study aimed to identify The Differences of Feelings of guilt Levels among Gifted Students  in Jordan And the possible differences among them attributed to their gender and age. Sample of the study consisted of (150) male and female students selected from gifted students enrolling at King Abdulla II Schools for Excellence in Irbid City selected using random sampling procedures. To achieve the aim of the study, the researcher used Henderson and Zimbardo (2008) scale translated to Arabic by Shaker (2011). The scale was adapted to the Jordanian culture. Results of the study indicated that the means scores for feelings of guilt among study sample was moderately estimation level. There were significant differences in feelings of guilt levels among study sample due to age, in favor of Age group (15-16) years.The results showed that there were no statistically significant differences in feelings of shyness levels due to the variable gender differences. In light of the results reported in the current study, the researcher recommended the need for educators at King Abdulla II Schools for Excellence to develop strategies and programs to reduce feelings of guilt levels. Keywords: Feelings of guilt, Gifted Students, Jordan

Validation of High School Tests: Teaching Syllabus vs. Testing Procedures

The present book aim to highlight one important issue before any high school teacher's eyes: it is necessary to understand the purpose of testing in high schools. What is the role of high school tests? Should they be considered as real tests? Or can they be perhaps best regarded as a ceremony, a cathartic ritual to be undergone alone with other examinations of this type before holiday? We hope that book may lead teachers to focus more on testing procedures as a complementary step in language learning and teaching. This will help them to see that everyone has areas of strength and areas of challenge, and that it is worthwhile to use every opportunity, even the testing sessions, for improving the learners achievements in language proficiency

Differences in Shyness Feeling Levels among Gifted Students at King Abdullah II Schools for Excellence

The study aimed to identify The Differences of Shyness Levels among Gifted Students in Jordan and the possible differences among them attributed to their gender and age. Sample of the study consisted of (120) male and female students selected from gifted students enrolling at King Abdulla II Schools for Excellence in Irbid City selected using random sampling procedures. To achieve the aim of the study, the researcher used Henderson and Zimbardo (2008) scale translated to Arabic by Shaker (2011). The scale was adapted to the Jordanian culture. Results of the study indicated that the means scores for feelings of shyness among study sample was moderately estimation level. There were significant differences in feelings of shyness levels among study sample due to age, in favor of Age group (15-16) years.The results showed that there were no statistically significant differences in feelings of shyness levels due to the variable gender differences. In light of the results reported in the current study, the researcher recommended the need for educators at King Abdulla II Schools for Excellence to develop strategies and programs to reduce feelings of shyness levels. Keywords: Feelings of Shyness, Gifted Students, King Abdullah II Schools For Excellence

Status of Services Provided to Deaf Woman in the Hashemite Kingdom of Jordan

This study aimed at identifying the status of services provided to deaf woman in Jordan. The study was conducted on a sample of (100) deaf women chosen by the intended available method. A researcher self developed questionnaire consisting of (75) items covering seven most important domains representing the most important services that should be provided to deaf women, using yes/ No scale for responses.Results showed that instrument mean score for the scale of effectiveness of services provided to deaf women wan moderate (0.42). Results also showed health care dimension between northern region and the central regions where differences were in favor of central region, between southern and northern regions in furor of northern region, and between central and southern region in favor of central region. Also there were statistically significant differences in the level of effectiveness for sport and entertainment domain between central region, from the one hand and both southern and northern regions from the other, and in favor of central region. Keywords: China insurance industry, Foreign fund, Challeng