Prevention of the onset of hyperglycaemia by extracts of Aloe barbadensis in rabbits treated with alloxan

The ability of a home-made aqueous extract of Aloe barbadensis to prevent the onset of alloxaninduced hyperglycaemia was examined and compared with that of a factory-produced gel. Three groupsof animals were administered 200 mg/kg body weight of alloxan intraperitoneally. A fourth group of animals was left uninjected. Animals in group 2 also received a uniform administration of 1 mg/ml twicedaily oral intake of Aloe gel (the home-made extract) commenced at the same time the alloxan was administered and continued thereafter for the next six days. Animals in group 3 were administered the factory-produced extract in a similar way as was done for animals in group 2. Plasma glucose levels at the end of the experiment were 142.50±6.28, 82.50±2.72, 88.17±1.92 and 94.17±1.51mg/dl for animals in groups 1, 2, 3 and 4, respectively. Alloxan administration possibly resulted in an increase of 51% in the plasma glucose level of animals in group 1 relative to animals in group 4 (

Chemical constituents and antioxidant activity of Alstonia boonei

The chemical composition and some antioxidant indices of Alstonia boonei stem-bark extract were evaluated. A. boonei was found to contain important minerals like calcium, phosphorus, iron, sodium, potassium, and magnesium. Alkaloids, tannins, saponins, flavonoids and cardiac glycosides were among the phytochemicals detected together with the important vitamin, ascorbic acid. DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, total phenolic content and reducing power were41.58 ± 1.43 %, 2.09 ± 0.04 mg/g gallic acid equivalent and 0.32 ± 0.01 respectively. Against the backdrop of the many medicinal uses of the plant, the results of the present work indicate that phytochemicals, other than phenolics, the mineral elements and vitamin C may be the critical factors in the medicinal effects of A. boonei

Identification of a Novel Calotropis procera Protein That Can Suppress Tumor Growth in Breast Cancer through the Suppression of NF-κB Pathway

10.1371/journal.pone.0048514PLoS ONE712

Polyphenol analysis using high‐resolution mass spectrometry allows differentiation of drought tolerant peanut genotypes

BACKGROUND: Peanut (Arachis hypogaea L.) is an important economic food crop highly appreciated worldwide. Although peanut cultivation has been expanding to dry regions, with water stress during growth stages, current genotypes are not adapted to drought. This study aimed to identify and quantify the full range of polyphenols in five peanut genotypes with different degrees of drought tolerance developed by Embrapa (Brazil) using ultra-high-definition accurate-mass liquid chromatography–electrospray ionization–LTQ-Orbitrap–mass spectrometry. RESULTS: Fifty-eight polyphenols of the classes hydroxybenzoic acids, hydroxycinnamic acids, flavanols, flavonols and flavanones were identified and quantified using high mass accuracy data and confirmed by tandem mass spectrometric experiments. High-definition mass spectrometric analyses revealed nine phenolic compounds that have never been reported in peanuts before. Polyphenol assessment using multivariate analysis allowed identification of the level of similarities among the five peanut genotypes studied. CONCLUSION: Higher drought-tolerant genotypes exhibited higher content of flavonoids, which suggests a relationship between these compounds and drought tolerance traits. © 2019 Society of Chemical Industry.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Departament d'Innovació, Universitats i Empresa, Generalitat de CatalunyaDepartment of Agri-food Industry Food and Nutrition ‘Luiz de Queiroz’ College of Agriculture University of São PauloDepartment of Food and Nutrition School of Pharmaceutical Sciences São Paulo State University-UNESPDepartment of Nutrition Food Sciences and Gastronomy XARTA INSA-UB School of Pharmacy and Food Sciences University of Barcelona Carrer de Prat de la RibaEmbrapa Cotton Brazilian Agricultural Research CorporationDepartment of Food and Nutrition School of Pharmaceutical Sciences São Paulo State University-UNESPFAPESP: 2016/0651FAPESP: 2016/16193-0Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya: GC 2014 SGR 773FAPESP: Grants # 2015/02986-