Probabilistic seismic hazard maps for the sultanate of Oman

This study presents the results of the first probabilistic seismic hazard assessment (PSHA) in the framework of logic tree for Oman. The earthquake catalogue was homogenized, declustered, and used to define seismotectonic source model that characterizes the seismicity of Oman. Two seismic source models were used in the current study; the first consists of 26 seismic source zones, while the second is expressing the alternative view that seismicity is uniform along the entire Makran and Zagros zones. The recurrence parameters for all the seismogenic zones were determined using the doubly bounded exponential distribution except the zones of Makran, which were modelled using the characteristic distribution. Maximum earthquakes were determined and the horizontal ground accelerations in terms of geometric mean were calculated using ground-motion prediction relationships developed based upon seismic data obtained from active tectonic environments similar to those surrounding Oman. The alternative seismotectonic source models, maximum magnitude, and ground-motion prediction relationships were weighted and used to account for the epistemic uncertainty. Hazard maps at rock sites were produced for 5 % damped spectral acceleration (SA) values at 0.1, 0.2, 0.3, 1.0 and 2.0 s spectral periods as well as peak ground acceleration (PGA) for return periods of 475 and 2,475 years. The highest hazard is found in Khasab City with maximum SA at 0.2 s spectral period reaching 243 and 397 cm/s[superscript 2] for return periods 475 and 2,475 years, respectively. The sensitivity analysis reveals that the choice of seismic source model and the ground-motion prediction equation influences the results most.Oman Ministerial Cabinet (project number 22409017

Deterministic seismic hazard assessment for Sultanate of Oman

The Sultanate of Oman forms the southeastern part of the Arabian plate, which is surrounded by relatively high active tectonic zones. Studies of seismic risk assessment in Oman have been an important on-going socioeconomic concern. Using the results of the seismic hazard assessment to improve building design and construction is an effective way to reduce the seismic risk. In the current study, seismic hazard assessment for the Sultanate of Oman is performed through the deterministic approach with particular attention on the uncertainty analysis applying a recently developed method. The input data set contains a defined seismotectonic model consisting of 26 seismic zones, maximum magnitudes, and 6 alternative ground motion prediction equations that were used in four different tectonic environments: obduction zone earthquake (Zagros fold thrust belt), subduction zone earthquakes (Makran subduction zones), normal and strike-slip transform earthquakes (Owen and Gulf of Aden zones), and stable craton seismicity (Arabian stable craton). This input data set yielded a total of 76 scenarios at each point of interest. A 10 % probability that any of the 76 scenarios may exceed the largest median ground acceleration is selected. The deterministic seismic hazards in terms of PGA, 5 % damped spectral acceleration at 0.1, 0.2, 1.0 and 2.0 s are performed at 254 selected points. The ground motion was calculated at the 50th and 84th percentile levels for selected probability of exceeding the median value. The largest ground motion in the Sultanate of Oman is observed in the northeastern part of the country.Oman Ministerial Cabinet (Project 22409017

Seismic microzonation for Muscat region, Sultanate of Oman

Site characterization was carried out for Muscat region using the ambient noise measurements applying the horizontal-to-vertical spectral ratio (HVSR) technique and using active seismic survey utilizing the multichannel analysis of surface waves (MASW) of survey data. Microtremors measurements were carried out at 459 sites using short-period sensors. This extensive survey allowed the fundamental resonance frequency of the soft soil to be mapped and areas prone to site amplification to be identified. The results indicate a progressive decrease in the fundamental resonance frequencies from the southern and eastern parts, where the bedrock outcrops, toward the northern coast where a thickness of sedimentary cover is present. Shear wave velocity (Vs) was evaluated using the 2-D MASW at carefully selected 99 representative sites in Muscat. These 99 sites were investigated with survey lines of 52 m length. 1-D and interpolated 2-D profiles were generated up to a depth range 20–40 m. The vertical Vs soundings were used in the SHAKE91 software in combination with suitable seismic input strong motion records to obtain the soil effect. Most of the study area has amplification values less than 2.0 for all the considered spectral periods. The estimated fundamental frequencies obtained using the H/V spectral ratio method and using SHAKE91 are found to be in a relatively good agreement. Maps of spectral amplification, earthquake characteristics on the ground surface for peak ground and spectral accelerations at 0.1, 0.2, 0.3, 1.0, and 2.0 s, for 475 years return period are produced. The surface ground motion maps show that the hazard level is moderate with expected PGA in the range 0.059–0.145 g for 475 years return period.Oman Ministerial Cabinet (project # 22409017

Temporomandibular Joint Ankylosis as a Complication of Neonatal Septic Arthritis : Report of two cases

Temporomandibular joint (TMJ) ankylosis as a complication of neonatal septic arthritis is rarely reported in the literature. We report two clinical cases of unilateral TMJ ankylosis occurring in paediatric patients subsequent to neonatal septic arthritis. The first case was a 15-month-old male infant who presented to the Sultan Qaboos University Hospital, Muscat, Oman, in May 2010. According to the published English scientific literature, he is the youngest person yet to be diagnosed with this condition. The second case was a five-year-old female who presented to the Al-Nahda Hospital, Muscat, Oman, in October 2011. Both cases presented with facial asymmetry and trismus. They subsequently underwent gap arthroplasty and interpositional temporalis muscle and fascia grafts which resulted in an immediate improvement in mouth opening. Postoperatively, the patients underwent active jaw physiotherapy which was initially successful. Both patients were followed up for a minimum of two years following their surgeries

Mesoscale and Nutrient Conditions Associated with the Massive 2008 Cochlodinium polykrikoides Bloom in the Sea of Oman/Arabian Gulf

Cochlodinium polykrikoides formed large blooms in the coastal waters of Oman from October 2008 through mid-January 2009, and satellite images from Aqua-MODIS and region-wide reports suggest that this bloom was found throughout the Arabian Gulf and Sea of Oman for more than 10 months. The unusual occurrence of this species appears to have supplanted the more regularly occurring bloom species, Noctiluca scintillans, in 2008–2009. For the first 2 weeks of the coastal Omani bloom, C. polykrikoides abundance was near monospecific proportions, with cell densities ranging from 4.6 × 103 to 9 × 106 cells L−1 and very high levels of chlorophyll a (78.0 μg L−1) were also recorded. The regional progression of the bloom likely began with stronger than normal upwelling along the Iranian and northern Omani coasts during the southwest monsoon in late summer, followed by discharge of unusually warm coastal plume water along the coast of Oman with the reversal of monsoonal winds in late October. The occurrence and persistence of high densities of C. polykrikoides in Oman coastal water were also significantly influenced by an elevated nutrient load and warmer than normal temperatures. Concentrations of nutrients, especially NH4 +, urea, PO4 3−, and organic nitrogen and phosphorus, were manyfold higher than observed in the year prior or since. These findings suggest that mesoscale features were important in bloom dynamics more regionally, but locally the bloom was sustained by nutrient enrichment supplemented by its mixotrophic capabilities

Electrochemical monitoring of the oxidative coupling of alkynes catalyzed by triphenylphosphine gold complexes

Electrochemical monitoring of the oxidative coupling of alkynes in the homogeneous phase through catalytic cycles involving triphenylphosphine gold complexes and selectfluor as oxidant reveals that at least two gold species in +3 and +1 oxidation states are implicated. Electrochemically driven homocoupling of terminal alkynes using molecular oxygen as the oxidant can be performed using such catalysts.Domenech Carbo, A.; Leyva Perez, A.; Al-Resayes, SI.; Corma Canós, A. (2012). Electrochemical monitoring of the oxidative coupling of alkynes catalyzed by triphenylphosphine gold complexes. Electrochemistry Communications. 19:145-148. doi:10.1016/j.elecom.2012.02.038S1451481

Impact of Safety-Related Dose Reductions or Discontinuations on Sustained Virologic Response in HCV-Infected Patients: Results from the GUARD-C Cohort.

BACKGROUND: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. METHODS: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. RESULTS: SVR24 rates were 46.1% (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1, 2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced ≥1 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with ≥1 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not ≥5. CONCLUSIONS: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginterferon alfa-2a/ribavirin.This study was sponsored by F. Hoffmann-La Roche Ltd, Basel, Switzerland. Support for third-party writing assistance for this manuscript, furnished by Blair Jarvis MSc, ELS, of Health Interactions, was provided by F. Hoffmann-La Roche Ltd, Basel, Switzerland

Influence of Light Availability and Prey Type on the Growth and Photo-Physiological Rates of the Mixotroph Noctiluca scintillans

A strain of the mixotrophic green Noctiluca scintillans (Noctiluca) isolated from the Arabian Sea afforded us an opportunity to investigate the photosynthetic and feeding characteristics of this organism which has recently replaced the once diatom dominated food chain of winter blooms in the Arabian Sea. Here we present the first in a series of experiments undertaken to study the interactive effects of irradiance and grazing response of this mixotroph to four phytoplankton species provided as food. Noctiluca showed a distinct preference for the dinoflagellate Peridinium foliaceum and the pennate diatom Phaeodactylum tricornutum, but not for the chlorophyte Pyramimonas sp., nor the chain forming diatom Thalassiosira weissflogii. However, irrespective of the food provided, adequate light was required for Noctiluca to grow as evidenced by its maximum growth rates of 0.3 day-1 when fed the preferred dinoflagellate Peridinium and exposed to optimal irradiance of 250 μE m-2 s-1 vs. growth rates of 0.13 day-1 with the same food but at a low irradiance of 10 μE m-2 s-1. Measurements of Noctiluca’s electron transport rates (ETR) per PSII Reaction Center as a function of irradiance also indicated severe light limitation of photosynthesis at 10 μE m-2 s-1. The active fluorescence derived ETR vs. Irradiance curves also revealed an interesting finding in that there was no significant difference in photosynthetic parameters such as the maximum photosynthetic capacity (ETRmax) nor α, the rate of increase of photosynthesis with light between fed and unfed cells under optimal light conditions. These results suggest that feeding does not enhance the photosynthetic activity of the endosymbionts when nutrients are not limiting as was the case in these experiments. Measurements of Noctiluca’s intracellular ammonium concentrations under optimal light conditions, the first for this strain, show significant accumulation of NH4+ (0.003–0.012 μM NH4+ cell-1) after 14 days for fed and unfed Noctiluca which was undetectable 4 days later. A similar 14-day increase but of significantly higher concentrations (0.005–0.08 μM NH4+ cell-1) was obtained under low light conditions. For P. tricornutum and T. weissflogii fed cultures under light limitation, NH4+ continued to increase past the 14-day period suggesting a strong and efficient mechanism for regulation of intracellular nutrients by Noctiluca

Functional Analysis of the Cathepsin-Like Cysteine Protease Genes in Adult Brugia malayi Using RNA Interference

Filarial nematodes are an important group of human pathogens, causing lymphatic filariasis and onchocerciasis, and infecting around 150 million people throughout the tropics with more than 1.5 billion at risk of infection. Control of filariasis currently relies on mass drug administration (MDA) programs using drugs which principally target the microfilarial life-cycle stage. These control programs are facing major challenges, including the absence of a drug with macrofilaricidal or permanent sterilizing activity, and the possibility of the development of drug-resistance against the drugs available. Cysteine proteases are essential enzymes which play important roles in a wide range of cellular processes, and the cathepsin-like cysteine proteases have been identified as potential targets for drug or vaccine development in many parasites. Here we have studied the function of several of the cathepsin-like enzymes in the filarial nematode, B. malayi, and demonstrate that these cysteine proteases are involved in the development of embryos, show similar functions to their counterparts in C. elegans, and therefore, provide an important target for future drug development targeted to eliminate filariasis

Displacement, integration and identity in the postcolonial world

Defining the relationship between displaced populations and the nation state is a fraught historical process. The Partition of India in 1947 provides a compelling example, yet markedly little attention has been paid to the refugee communities produced. Using the case of the displaced ‘Urdu-speaking minority’ in Bangladesh, this article considers what contemporary discourses of identity and integration reveal about the nature and boundaries of the nation state. It reveals that the language of ‘integration’ is embedded in colonial narratives of ‘population’ versus ‘people-nation’ which structure exclusion not only through language and ethnicity, but poverty and social space. It also shows how colonial and postcolonial registers transect and overlap as colonial constructions of ‘modernity’ and ‘progress’ fold into religious discourses of ‘pollution’ and ‘purity’. The voices of minorities navigating claims to belonging through these discourses shed light on a ‘nation-in-formation’: the shifting landscape of national belonging and the complicated accommodations required