Cell therapy in chronic rhinosinusitis in children

Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroduction. Chronic Rhinosinusitis is one of the most common chronic diseases worldwide, having an incidence between 1%-12% Globally and an incidence of 10.9% in Europe. CRS (Chronic Rhinosinusitis) is an underestimated disease, this condition leads to a significant impact on the quality of life of the patients it affects, furthermore, CRS has an unquestionable impact on a societal level with increasing economic losses attributed to this disease. Aim of study. This literature review aims to find and discuss evidence that relates to the complex treatment of CRS with Cell Therapy, putting in the spotlight the molecular, morphological, and structural nuances that stand at the base of understanding CRS and its treatment with Cell Therapy. Methods and materials. For the elaboration of this literature review, scientific evidence about the efficacy of Cell Therapy in CRS was collected from sources such as ScienceDirect, PubMed, The International Journal of Cell Differentiation and Proliferation, and The Moldovan Medical Journal. Results. In a study conducted on 19 pediatric patients with CRS and 116 healthy children, statistically significant differences were found. CRS patients have shown higher levels of IG E (9.2±0.27 vs 57.9±22.79) and CD4/CD8 thus showing an allergic and inflammatory implication. ASL-O was also significantly higher in patients suffering from CRS in contrast to the healthy control group (11.5±2.08 vs 178±96.5). In addition, a statistically significant decrease of Tlymphocyte activity was reported in ill individuals in comparison to healthy individuals. Furthermore, an increase of B-lymphocyte activity was noted with the increase in IG A levels. Treatment using cell therapy was administered, the study group was treated and assessed over a period of one year. During this period clinically significant improvements were noted, a decrease in nasal resistance, and an increase in total volume indices were found in all children treated with autologous mononuclear cells. Another In Vivo study has shown the role of mesenchymal stem cells in the treatment of CRS. 70 subjects were studied, of which 32 were the control group and 32 where exposed to Aspergillus fumigatus, 12 of those exposed to Aspergillus fumigatus underwent treatment with mesenchymal stem cells (MSC). Subjects treated with MSC daily evolution were monitored, which showed great improvement in contrast with the group that did not undergo MSC treatment. Histological lesions were minimal, and most of the sinuses and nasal mucosa were found to be normal. Furthermore, Patients that underwent Cell therapy have shown lesser resistance to antibiotics. Conclusion. The aforementioned results have shown evidence that Cell Therapy is effective in the complex treatment of CRS. having an incidence between 1%-12% Globally and an incidence of 10. 9% in Europe. CRS (Chronic Rhinosinusitis) is an underestimated disease, t his condition leads to a significant impact on the quality of life of the patients it affects, furt hermore, CRS has an unquestionable impact on a societal level with increasing economic losses attrib uted to this disease. Aim of study. This literature review aims to find and discuss evidence that relates to the complex treatment of CRS with Cell Therapy, putting in the spotlight the molecular, morphological, and structural nuances that stand at the base of understanding CRS and its treatment with Cell Therapy. Methods and materials. For the elaboration of this literature review, scienti fic evidence about the efficacy of Cell Therapy in CRS was collected from sourc es such as ScienceDirect, PubMed, The International Journal of Cell Differentiation and Prolif eration, and The Moldovan Medical Journal. Results. In a study conducted on 19 pediatric patients with CRS an d 116 healthy children, statistically significant differences were found. CRS pat ients have shown higher levels of IG E (9.2±0.27 vs 57.9±22.79) and CD4/CD8 thus showing an allergic and inflamm atory implication. ASL-O was also significantly higher in patients suffering fr om CRS in contrast to the healthy control group (11.5±2.08 vs 178±96.5). In addition, a statistically significant decrease of Tlymphocyte activity was reported in ill individuals in compar ison to healthy individuals. Furthermore, an increase of B-lymphocyte activity was n oted with the increase in IG A levels. Treatment using cell therapy was administered, the study gro up was treated and assessed over a period of one year. During this period clinically significant i mprovements were noted, a decrease in nasal resistance, and an increase in total volume ind ices were found in all children treated with autologous mononuclear cells. Another In Vivo study has shown the role of mesenchymal stem cells in the treatment of CRS. 70 subjects were studied, of which 32 were the control group and 32 where exposed to Aspergillus fumigatus, 12 of those exposed to Aspergillus fumigatus underwent treatment with mesenchymal stem cells (MSC). Subjec ts treated with MSC daily evolution were monitored, which showed great improvement in c ontrast with the group that did not undergo MSC treatment. Histological lesions were mi nimal, and most of the sinuses and nasal mucosa were found to be normal. Furthermore, Patients tha t underwent Cell therapy have shown lesser resistance to antibiotics. Conclusion. The aforementioned results have shown evidence that Cel l Therapy is effective in the complex treatment of CRS

On Skew Left n-Derivations with Lie Ideal Structure

In this paper the centralizing and commuting concerning skew left -derivations and skew left -derivations associated with antiautomorphism on prime and semiprime rings were studied and  the commutativity of Lie ideal under certain conditions were proved

An assessment of the legality of fake news within the mainstream media – with specific regard to its influence on the political climate

This article aims to investigate whether the law and regulation provided by the government is sufficient in tackling the increasing issue of fake news (FN) ‘‘a false story that appears to be news, usually created to influence political views’’.2 An examination on whether increased regulation would restrict the United Kingdom’s tradition of a free, investigative press, will be comparatively analysed to serve a contrast in perspectives to the laxer attitudes of the American media system. With the rapid evolution of technology, the radical influence FN has on the political climate will likely increase. A 2015 poll showed that 41% of Americans still erroneously believed that active weapons of mass destruction had been found in Iraq,3 but it has been proven that none ever existed.4 This worrying statistic demonstrates the influence that the media maintains over the public. Examination of regulations, laws and ethical arguments will determine whether there is a practical and reasonable solution to this epidemic, and if the government should be putting more effort in to address i

Enhanced oil recovery by smart water injection in sandstone reservoirs (Malaysian Crude Oil)

Recently, the scale of studies on smart water – one of EOR method - has increased. From decades, water flooding is one of the most used methods to increase oil recovery. However, more effective in sandstone reservoirs is injecting low salinity brine. Due to changing wettability, improved oil mobility in pores can be reached. The studies show, that the significant increase of oil recovery might be achieved. Main objective of the project is to answer the question: Can “smart water” be used to enhance oil recovery in Malaysian sandstone reservoirs. Laboratory experiments and field tests show that it can enhance the oil recovery over conventional higher salinity water flooding. Until now, the mechanism behind low salinity water flooding is under consideration for further discussions, but it is generally accepted that low salinity water flooding improves microscopic sweep efficiency by modifying rock wettability. For low salinity condition, it has been suggested that desorption of polar oil components as result of pH increase makes the rock more water-wet. In this project, three core flood experiments will be performed to determine the effect of different water salinities on the oil recovery. Two homogeneous reservoir cores which contain active clays with crude oil which has enough polar organic compounds will be used during the experiments. All experiments were conducted at reservoir temperature, around 100°C. Core flood effluents will be sampled regularly to investigate crude oil-brine-rock interactions by measuring pH, density, and different ions concentration of produced water. Comparison between the results of the three types of water and its effect on the recovery factor will be conducted

Maritime boundary delimitation of the kingdom of Saudi Arabia a study in political geography

Saudi Arabia was the first Arab country to claim offshore jurisdiction and the first Middle Eastern state to define its offshore waters. This study examines the principal geographical factors which have resulted in the present Saudi maritime boundary. The semi-enclosed sea, islands, reefs, natural resources of the continental shelf, exclusive economic zone and coastline, can all be considered principal geographical factors that have influenced Saudi territorial waters policy. Islands, for example, play an effective role in increasing the area of Saudi internal waters, increasing the breadth of the territorial sea, straight baseline and the delimitation of maritime boundary in the Red Sea and the Arabian Gulf with opposite and adjacent states. Natural resources demanded the swift implementation of unique agreements, used later as an example worldwide. The author has drawn the 1958 Saudi straight baseline and a theoretical straight baseline based on the 1982 Convention and states practice. The territorial sea which is drawn on this basis along the Red Sea and the Arabian Gulf coasts, is affected by the presence of islands and reefs. The Saudi Exclusive Fishing Zone claimed by the 1974 decree gave the Kingdom the same right as the 1982 Exclusive Economic Zone (EEZ), but the Kingdom had to adapt the latter in order to gain more control over its resources and non-mineral activities. The importance of the 1949 Saudi decree can be found in the contribution made by Saudi Arabia to the development of the law of the sea, and to safeguarding the national hydrocarbon resources (natural gas and oil) on and below its seabed. Saudi Arabia engaged in several agreements, mainly in the Gulf, in order to define its boundary. This study has highlighted these agreements as a model which can be used in different parts of the world to solve similar disputes, and can be adopted as methods of maritime delimitation between opposite and adjacent states. The importance of the economic factor has been shown, along with security, as the main factor influencing the successful conclusion of such agreements, but where there is no such importance, the boundary may become less significant and by the absence of such motivation the boundary may not be defined. Saudi waters are a rich and highly important maritime area. This is based on the facts that Saudi Arabia has 30 per cent of the world seawater desalination plants; that the sea represents food, fuel and wealth to Saudi Arabia; and that the existence of huge deserts emphasises the importance of the sea

The Effect of Teaching Using Artificial Intelligence Software’s on the Academic Achievement of the 10th Grade Students in Computer Science Subject and Their Attitudes Towards It in Jordan

This study aims to identify the effect of the teaching method using educational software based on artificial intelligence in the academic achievement of 10th-grade students in computer science in Jordan and their attitudes towards it. To achieve the goal of this study, a computerized software was designed to be applied to a purposefully selected sample consisting of (50) 10th-grade students at The University of Jordan School. The study sample was randomly distributed into two groups: an experimental sample taught using the educational software, and a control sample taught in the traditional method, where the researcher prepared an achievement test to measure the academic achievement of the 10th-grade students in the Computer Science Subject, where the validity and reliability of the test has been validated, and the test-retest reliability coefficient was (0.86). A questionnaire was prepared for the attitudes, where their validity and reliability were validated. The reliability factor of the questionnaire based on Cronbach’s alpha equation was (0.01). To analyze the results, an analysis of covariance (ANCOVA) was used, where the results of the study showed that there are statistically significant differences in favor of the experimental group taught using educational software based on artificial intelligence in learning computer science subject. The results also showed that there are medium positive attitudes of the experimental group towards educational software. The study recommended designing and developing computerized software in the field of teaching computer science subject s and training and encouraging teachers to use artificial intelligence-based learning in the field of basic education. Keywords: artificial intelligence software, academic achievement, student attitudes, University of Jordan School DOI: 10.7176/JEP/11-7-10 Publication date:March 31st 202

Electricity-theft detection in smart grids based on deep learning

lectricity theft is a major concern for utilities. The smart grid (SG) infrastructure generates a massive amount of data, including the power consumption of individual users. Utilizing this data, machine learning, and deep learning techniques can accurately identify electricity theft users. A convolutional neural network (CNN) model for automatic electricity theft detection is presented. This work considers experimentation to find the best configuration of the sequential model (SM) for classifying and identifying electricity theft. The best performance has been obtained in two layers with the first layer consists of 128 nodes and the second layer is 64 nodes. The accuracy reached up to 0.92. This enables the design of high-performance electricity signal classifiers that can be used in several applications. Designing electricity signals classifiers has been achieved using a CNN and the data extracted from the electricity consumption dataset using an SM. In addition, the blue monkey (BM) algorithm is used to reduce the features in the dataset. In this respect, the focusing of this work is to reduce the features in the dataset to obtain high-performance electricity signals classifier models

Ozonetherapy in hypertension and ischemic diseases

Introduction. Cardiovascular pathologies are the leading cause of death worldwide. These diseases can be either the main cause of death or an underlying condition that aggravates the patient’s prognosis. About 17.9 million people die per year from cardiovascular disease, of which 85% come from low- to middle-income countries, in whose classification The Republic of Moldova takes part of. Furthermore, atherosclerosis is an underlying condition in about 50% of all fatal cases that take place in western countries. There are multiple ways of treating cardiovascular diseases, of which an underused but effective method is ozonetherapy which is useful for its vasodilatory, anti-aggregative, anti-inflammatory properties, and for its role in the oxidation of tissues. Aim of study. As the background, we have identified pathologies that are a leading cause for death or a chronic physical ailment that could change the patient's way of living life, after which we have identified statistically significant studies that have used Ozonetherapy be it to study the effects of Ozonetherapy in the body, as a treatment option to enhance the prognosis of patients suffering from atherosclerosis or its efficacy in the rehabilitation of patients that have already suffered from a heart attack or other cardiological diseases. Methods and materials. For the purpose of the study, we have accessed literature from relevant sources that is found in books or in databases, such as NihGov, PubMed, NCBI, and ScienceDirect. With the usage of keywords such as “Ozonetherapy”, “Atherosclerosis”, “Ischemic heart disease”, “Hypertension”, “Heart attack”, “oxidative stress”. Results. After reviewing the relevant sources and verifying their legitimacy, we have found statistically significant improvements in parameters that are relevant for hypertension where the endothelin-1, Renin, and Nitric Oxide levels of subjects that had Hypertension induced and had subsequently undergone Ozonetherapy presented levels similar to the control group with p<0.05, paradoxical anti-oxidative proprieties where shown to be present as well. After 5 and 15 sessions of Ozone therapy, Cholesterol levels dropped by 5.5% and 9.7% respectively, LDL levels were found to be significantly reduced by 15.4% and 19.8% respectively, while no significant modification was found in HDL levels, these molecules being Major contributors or inhibitors of Atherosclerosis pathogenesis. Ozonetherapy has shown its efficacy in enhancing the odds of a favorable prognosis in patients with peripheral atherosclerosis and in the rehabilitation of post-stroke patients as well. Conclusion. Ozonetherapy is an underused but effective minimally invasive method in the treatment of patients with heart disease, in controlled dosages using methods such as abdominal insufflation, Ozone-treated NaCl solutions (“Physiological solution”), Minor and or Major Auto-Hemotherapy, Ozonetherapy improves the prognosis of patients suffering from ischemic heart disease by increasing the adaptability of the body to oxidative stress, as well as by transforming cholesterol into oxysterol that is later taken up by Lipoprotein molecules and processed in the hepatocytes. The importance of which is highlighted by the fact that Oxidative stress and cholesterol are major causes of ischemic heart disease. Thus concluding that Ozonetherapy is worthy of more studies and subsequently enhancing the frequency of its usage in a clinical environment

منطلقات الانحراف الفكري لدى آمنة ودود في كتابها القرآن والمرأة The Premises of Intellectual Deviation of Amna Wadoud in her Book “Quran and Women”

تمّ في هذه الدراسة الكشف عن المنطلقات الفكريّة التي ارتكزت عليها آمنة ودود في تفسيرها للآيات القرآنيّة المتعلّقة بمكانة المرأة وعلاقتها بالرجل في كتابها (القرآن والمرأة)، ثم نقد تلك المنطلقات بميزان الأدلّة النقليّة والعقليّة، بالإضافة لمناقشة أهمّ آرائها المتعلقة بمكانة المرأة في القرآن. من نتائج الدراسة: أولاً: اعتمدت آمنة ودود منطلقات فكريّة حداثيّة، نتج عنها أحكام مُخالفة لمراد القرآن فيما يتعلّق بقضايا المرأة. ثانياً: لقراءة ودود النسويّة للقرآن مقصدان رئيسان: الطعن في التراث التفسيري لعلماء المسلمين، وتصويره بأنَّهُ تفسير ذكوري غير موضوعي. شرعنة المساواة الجندريّة وآراء المنظمات النسويّة المتطرّفة، الداعية لتحرير المرأة من أحكام الإسلام. الكلمات المفتاحيّة: القرآن والمرأة، آمنة ودود، تفاسير نسويّة جندريّة. The present study explores the intellectual premises on which Amna Wadoud relied in her interpretation of the Quranic verses related to the status of women and their relationship with men in her book (Qur’an and Women). The study also criticizes these premises using both textual and rational evidence and discusses Wadud’s most important views regarding the status of women in the Qur’an. The main findings of the study are: First: Amena Wadoud bases her views on modern intellectual premises, which resulted in judgments contradicting the Quranic views on women’s issues. Second: Wadoud’s feminist reading of the Quran serves two main goals: Contesting Muslim scholars’ exegetical heritage and portraying it as a subjective masculine interpretation. Legitimizing gender equality and the views of extremist feminist organizations which seek to liberate women from the rulings of Islam. Key words: Quran and Women; Amena Wadoud; Feminist Gender Interpretations

fMRI correlates of ICD-11 taxonomies of chronic primary pain and chronic secondary musculoskeletal pain: systematic reviews and meta-analyses

Importance: Chronic pain encompasses complex mechanisms that remain incompletely understood. The World Health Organisation’s recent classifications of chronic primary pain and chronic secondary musculoskeletal pain in International Classification of Disease, 11th revision, highlights the need to examine their neural substrates systematically. Neuroimaging studies have shown inconsistent results, underscoring the importance of synthesising evidence on neural mechanisms underlying chronic pain. Objective: This thesis investigates the neural substrates associated with chronic primary pain and chronic secondary musculoskeletal pain using fMRI meta-analyses. Data extraction and Synthesis: Twenty-three whole-brain coordinate-based meta-analyses, explores whether differences in brain activity during provoked and ongoing pain converge spatially within and between chronic primary pain, chronic secondary musculoskeletal pain, and pain-free individuals. Analyses applied activation likelihood estimation, incorporating robust statistical controls for multiple comparisons to reduce false positives by enhancing sensitivity and spatial specificity. Results: For chronic primary pain, meta-analyses of 48 studies (75 experiments, 1,206 patients, 846 pain-free) conjunction analysis revealed significant convergence in the dorsal anterior insula, mid-cingulate cortex, and medial frontal gyrus (MFG). Contrasts highlighted stronger activation in the ventral anterior insula for chronic primary pain and the superior frontal gyrus for pain-free. Behavioural data confirmed higher pain levels in chronic primary pain patients without publication bias. For chronic secondary musculoskeletal pain, 28 studies (62 experiments, 3,217 patients, 1,079 pain-free) showed significant differences in the subcallosal gyrus, inferior frontal gyrus (IFG), and MFG, compared to pain-free. Combined chronic secondary musculoskeletal pain (symptoms and no symptoms) analyses highlighted cerebellar and parahippocampal activity. While both chronic primary pain and chronic secondary musculoskeletal pain showed involvement of the claustrum, IFG, and anterior cingulate cortex, variability across studies was high. Conclusions and Relevance: This thesis calls for larger meta-analyses integrating within- and between-subject designs to refine chronic primary pain and chronic secondary musculoskeletal pain classifications. Improved methodological consistency and reporting are crucial for understanding shared and distinct neural substrates, advancing diagnostic frameworks and translational potential in neuroscience