Serum glucose concentration and lipid profile in racing horses

The aim of the present work was to evaluate serum glucose concentration and lipid profile in racing horses in Iraq. Blood samples were collected from the jugular vein of 92 clinically healthy racing horses (males and females, Arabian and Cross bred), 2-8 years old at Equestrian Club, Baghdad. Investigations included serum measurements of glucose (sg) and lipid profile parameters; total cholesterol (TC), Triglyceride (TG), high density lipoprotein- cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C) and the atherogenic ratio (LDL-C/HDL-C), in order to register the normal ranges and mean values of these measured parameters in Iraqi healthy racing horses. Results showed that the range and mean values ± standard error of sg were: 33.3 – 6.71 mmol/l and 5.17±0.07 mmol/l, respectively, whereas the TC was 2.07 – 4.22 mmol/l and 3.01±0.05 mmol/l, TG 0.6 – 1.47 mmol/l and 1.06±0.02 mmol/l, HDL-C 0.93 – 2.25 mmol/l and 1.50±0.03 mmol/l, LDL-C 0.10 – 2.12 mmol/l and 0.91±0.04 mmol/l, VLDL-C 0.31 -0.67 mmol/l and 0.55±0.02 mmol/l, respectively and the atherogenic ratio 0.66±0.03. The data present reference values and mean ± SE for sg and lipid profile parameters in healthy racing horses in Baghdad

Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients and 45 Tag SNPs in 7 Candidate Genes: A Prospective Study

Objective: Four types of antipsychotic-induced movement disorders: tardive dyskinesia (TD), parkinsonism, akathisia and tardive dystonia, subtypes of TD (orofacial and limb truncal dyskinesia), subtypes of parkinsonism (rest tremor, rigidity, and bradykinesia), as well as a principal-factor of the movement disorders and their subtypes, were examined for association with variation in 7 candidate genes (GRIN2B, GRIN2A, HSPG2, DRD3, DRD4, HTR2C, and NQO1). Methods: Naturalistic study of 168 white long-stay patients with chronic mental illness requiring long-term antipsychotic treatment, examined by the same rater at least two times over a 4-year period, with a mean follow-up time of 1.1 years, with validated scales for TD, parkinsonism, akathisia, and tardive dystonia. The authors genotyped 45 tag SNPs in 7 candidate genes, associated with movement disorders or schizophrenia in previous studies. Genotype and allele frequency comparisons were performed with multiple regression methods for continuous movement disorders. Results: Various tag SNPs reached nominal significance; TD with rs1345423, rs7192557, r

Association Between the 1291-C/G Polymorphism in the Adrenergic alpha-2a Receptor and the Metabolic Syndrome

The prevalence of the metabolic syndrome is increased in patients with schizophrenia compared with the general population. The strong interindividual differences in susceptibility to developing the metabolic syndrome suggests that the genetic makeup is a modulating factor. Part of the genetic puzzle can possibly be explained by variations in the gene coding for the adrenergic alpha-2a receptor (ADRA2A) because this receptor plays an important role in lipolysis. Three studies have found an association between the alpha-2a 1291-C/G polymorphism and antipsychotic induced weight gain, with conflicting results between whites and Asians. No studies have been published investigating the association between the 1291-C/G polymorphism and the metabolic syndrome. The primary objective of this cross-sectional study was to investigate the association between the ADRA2A 1291-C/G polymorphism and the metabolic syndrome in 470 patients using antipsychotic drugs. There was no significant association between carriership of the variant 1291-G allele and prevalence of the metabolic syndrome (odds ratio, 0.73; 95% confidence interval, 0.49Y1.15). Exploratory analysis showed an association between carriership of the variant 1291-G allele and a reduced prevalence of the metabolic syndrome in patients not currently using antipsychotics (odds ratio, 0.05; 95% confidence interval, 0.003Y0.97; P = 0.048). In conclusion, this study shows that the ADRA2A 1291-C/G polymorphism does not seem to be a strong predictor for long-term occurrence of the metabolic syndrome in antipsychotic using patients. Studies investigating this association using a prospective, or retrospective, design, as well as studies investigating this association in a nonpsychiatric population, are warranted

Evaluation of massive weight loss body contouring

Introduction: There is proven therapeutic benefit in bariatric surgery for obese patients. Consequently the National Institute of Clinical Excellence UK has provided referral guidelines for bariatric surgery. Successful bariatric surgery will result in massive weight loss and ptotic skin, which can cause significant functional and psychological problems. As the number of cases of bariatric surgery increases, a corresponding number of massive weight loss patients will require plastic surgery. In this novel field of post massive weight loss surgery there is a lack of understanding of the demographics, physical symptoms and psychological health of this new group of patients. The tools to assess them are few and not validated, the patient pathway is disjointed and there is no consensus on standardised provision. Method: A prospective multicentre, observational study of outcomes in 100 patients undergoing bariatric and post massive weight loss plastic surgery at 2 clinical sites was performed. Each patient followed a standard operating protocol. This included undergoing a semi structured interview, completing five patient-report outcome measures, having anthropometric measurements and clinical photographs taken. Conclusion: This observational study identified key psychosocial themes prevalent in massive weight loss patients, during their weight loss journey. It identified there are no validated patient reported outcome measures available specific to this cohort of patients. This work led to the development of a new validated tool for massive weight loss body contouring

Preparation and Study Hardness and Thermal Conductivity (Tc) to Polyester Resin Composite with (Titanium Dioxide, Zinc Oxide, Acrylonitril, Wood Flour Coconut

This study is attempt to improve thermal isolation through measuring thermal conductivity composite of on polyester resin with fillers of (TiO2, ZnO, Acrylonitril, wood flour Coconut (Wf). The grain size of the fillers is 200 µm. The number of samples is (16) in addition to the virgin sample; these samples are prepared by cast molding method for polyester with filler volume fractions (5%, 10%, 15% and 20%). Shore hardness tests were used to measure the hardness and Lee disk method for thermal conductivity. The experimental results showed that the (20% ZnO) sample has the maximum value of thermal conductivity where (20% w.f) has minimum thermal conductivity .on the other hand (15% ZnO) sample give the maximum value of hardness where (20% w.f) sample gave the minimum value of hardness. From this study there is an important factor that should be observed that is the relationship between hardness and thermal conductivity. The study prove that the experimental results satisfy the theoretical assumptions in that the additive material (fillers) of metals base increase thermal conductivity where the material of cellulose base decrease the thermal conductivity and give good thermal isolation but with low hardness and all the result above the refry sample

Proper names in the Arabic translation of "Harry Potter and The Goblet of Fire"

This paper examines how a set of the most common translation procedures used in transferring proper names in children’s fantasy literature is being applied in the Arabic translation of J. K. Rowling’s “Harry Potter and the Goblet of Fire”. The study adopts Fernandes’s classification of ten procedures to discuss the ways of rendering proper names from English to Arabic. The focus of the study is three - fold: (1) To shed light on the shortcomings of the Arabic translation when applying a translation procedure to transfer proper names. (2) To describethe effects of the adopted procedures on the textual and stylistic features of the target text as when compared to the English original. (3) To carry outanin-depth linguistic and contextual analysis to suggest solutions towards a more effective child-friendly transfer that takes into consideration the readability factor. The paper argues that the foreignization strategy adopted in this translation is so extreme and makes the translator too visible for the translation’ sown sake. Although a translator’s role is essential to the writing process and foreignization is a means to make this role visible, it should not be at the expense of the author’s intention and the ST’s meaning. The researcher calls for adoption of a more flexible yet consistent approach that effectively balances foreignization against domestication when translating proper names used in fantasy fiction into Arabic

A mobile-programmable smart mirror for ambient IoT environments

© 2017 IEEE. The purpose of this paper is to present a smart interactive mirror interface. In this paper, we describe the design and development of a futuristic mirror that offers simplified and customisable services to the home environment. On a par with the recent advances in the Internet of Things standards and applications, the mirror is designed to enable residents to control the household smart appliances and access personalised services; ensuring convenience in accessing these services with the slightest possible user intervention. The multipurpose user-friendly functionalities of the proposed mirror interface provide users with the versatility needed for better management and integration of daily tasks. A service oriented approach is adopted in the architecture of the proposed system. It consists mainly of two mobile applications devoted to the customisation of user profiles, which are displayed on the smart mirror interface once successfully paired. Moreover, in the proposed system, emphasis is particularly given to the user profile personalisation, as well as planned system interactivity and adaptability. Hence, the proposed system is set apart from others for its ease of use as well as its provision of various customised information services for user profile generation

Dried blood spot UHPLC-MS/MS analysis of oseltamivir and oseltamivircarboxylate-a validated assay for the clinic

The neuraminidase inhibitor oseltamivir (Tamiflu®) is currently the first-line therapy for patients with influenza virus infection. Common analysis of the prodrug and its active metabolite oseltamivircarboxylate is determined via extraction from plasma. Compared with these assays, dried blood spot (DBS) analysis provides several advantages, including a minimum sample volume required for the measurement of drugs in whole blood. Samples can easily be obtained via a simple, non-invasive finger or heel prick. Mainly, these characteristics make DBS an ideal tool for pediatrics and to measure multiple time points such as those needed in therapeutic drug monitoring or pharmacokinetic studies. Additionally, DBS sample preparation, stability, and storage are usually most convenient. In the present work, we developed and fully validated a DBS assay for the simultaneous determination of oseltamivir and oseltamivircarboxylate concentrations in human whole blood. We demonstrate the simplicity of DBS sample preparation, and a fast, accurate and reproducible analysis using ultra high-performance liquid chromatography coupled to a triple quadrupole mass spectrometer. A thorough validation on the basis of the most recent FDA guidelines for bioanalytical method validation showed that the method is selective, precise, and accurate (≤15% RSD), and sensitive over the relevant clinical range of 5-1,500 ng/mL for oseltamivir and 20-1,500 ng/mL for the oseltamivircarboxyl