Therapeutic strategies and treatment sequencing in patients with chronic lymphocytic leukemia: an international study of ERIC, the European Research Initiative on CLL

FUNDING: This project was supported in part by AbbVie; AIRC under 5 per Mille 2018-ID. 21198 program (to PG and GG); PNRR-MAD-2022-12375673 (Next Generation EU, M6/C2_CALL 2022), Italian Ministry of Health, Rome, Italy, Conceptual development of research organization (FNBr 65269705) provided by the Ministry of Health of the Czech Republic, and National Institute for Cancer Research (Programme EXCELLES, ID Project No. LX22NPO5102) funded by the European Union—Next Generation EU

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS

Pientalon kustannuslaskenta radikaalisti muuttuvassa markkinassa

Opinnäytetyöni on tehty yritykselle nimeltä Caiman Oy. Työn tarkoituksena on selvittää, miten nykyiset materiaalien markkinahinnat vaikuttavat pientalohankkeeseen ja työn laatuun nykyajan maailmantilanteessa. Tässä opinnäytetyössä tutkitaan myös, pystyykö Caiman Oy rakennusyhtiö saavuttamaan samanlaista laatutasoa nykyisillä markkinahinnoilla rakennusmateriaaleille kuin ennen COVID-19-pandemiaa ja Venäjän ja Ukrainan konfliktia. Mikäli työn laadun saavuttaminen samalle tasolle kuin ennen on vaikeaa huonon markkinatilanteen vuoksi, niin tällöin tutkitaan erilaisia tapoja toteuttaa pientalohanketta minimaalisin kustannuksin, mutta pitäen kuitenkin yllä hyvä laatutaso. Tavoitteena on myös arvioida eri rakennusmateriaaleja kriittisesti ja arvioida niiden saavutettavuutta sekä minimoida mahdollisimman paljon säilyttäen hyvä työn laatu ja auttaa Caiman Oy:tä hankkeen hallinnassa. Laskelmissa on tuotu kaksi eri rakennusteknistä ratkaisua, joista lasketaan kummallekin oma kustannuslaskelma. Kustannuslaskelmissa tulee näkyviin markkinahinnat ennen Covid-19-pandemiaa ja Venäjän ja Ukrainan konfliktia. Niistä näkyy myös, minkälaisia lisäkustannuksia on tullut ja kuinka paljon ne ovat nousseet nykytilanteessa. Opinnäytetyön lopputuloksien tarkoitusta tullaan hyödyntämään ja ottamaan huomioon Caiman Oy: toimitusjohtajan Antti Kivelän päätöksenteossa hankkeen käynnistämisen osalta. Tehdyt analyysit, laskelmat ja perustellut tiedot tarjoavat rakennusyhtiölle tukea päätöksenteossa. Opinnäytetyö keskittyy hankkeen toteuttamisen vaikutuksista ja mahdollisista hyödyistä rakennusyhtiölle Caiman Oy:lle. Analysoinnit markkinahinnoissa, kilpailutilanteesta ja asiakkaiden tarpeista, auttavat toimitusjohtajaa Kivelää hahmottamaan hankkeen potentiaaliset mahdollisuudet ja riskit sekä arvioimaan kilpailuetua materiaalienosalta markkinoilla

Indirect Field Orientation Control of Induction Machine With Detuning Effect

Induction motors (IM) arc characterized by complex, highly nonlinear time varying dynamics and inaccessibility of some states and outputs for measurements and hence may be considered as a challenging problem. Field orientation control (FOC ) methods of an induction machine achieve decoupled torque and flux dynamics leading to independent control of torque and flux as for separately excited DC motor, but there are sensitive to motor parameter variations. The present work select the indirect field orientation control (IFOC) as an effective method for eliminating the coupling effect. The results showed how well the drive performance has been improved by this control strategy. However, to what extent the control strategy can perform the decoupling relies on the accuracy of the slip frequency calculation. Unfortunately, the slip frequency depends on the rotor time constant that varies continuously according to the operational conditions and then the coupling effect may again arise. This paper investigates the improvement in the performance of the induction machine dynamics as the IFOC technique is utilized. Also, it investigates the degradation in dynamic performance when the rotor resistance is deviated from its nominal value.</jats:p

Comparative Study for Selection of the Optimum Mobile Phase for Separation of Caffeine and Paracetamol by Using TLC Chromatographic Method

Objective. To investigate the best mobile phase for separation of Paracetamol (PAR) and Caffeine (CAF) using TLC method. Methods. Different mobile phases which were mentioned in literature review were tried and retention times for both PAR and CAF were recorded for each experiment separately. Results : It was found that retardation factors for solvent A Rf (PAR) =0,59 and Rf(CAF)=0,90 ; for solvent B Rf(PAR)=0,92 and Rf(CAF)=0,81; Rf(PAR)=0,22 and Rf (CAF)=0,16. Solvent A is composed of n-hexane-ethyl acetate-ethanol (2.5 + 1.5 + 0.4, v/v/v), solvent B is composed of chloroform,ethyl acetate and ammonia (15,0 + 4,3 + 0,3 v/v/v) and solvent C is composed of methanol,glacial acetic acid and water (25,0 +4,3+70,7 v/v/v ). Conclusion: It was found that the best solvent for separation of CAF and PAR in TLC chromatographic method was composed of n-hexane-ethyl acetate-ethanol (2.5 + 1.5 + 0.4, v/v/v).</jats:p

ISSN 2I41-2596 ©2010 Academic Journals

Molecular characterization of antigens extracted from hydatid cysts of human and other intermediate host