Impurity-induced tuning of quantum well states in spin-dependent resonant tunneling

We report exact model calculations of the spin-dependent tunneling in double magnetic tunnel junctions in the presence of impurities in the well. We show that the impurity can tune selectively the spin channels giving rise to a wide variety of interesting and novel transport phenomena. The tunneling magnetoresistance, the spin polarization and the local current can be dramatically enhanced or suppressed by impurities. The underlying mechanism is the impurity-induced shift of the quantum well states (QWS) which depends on the impurity potential, impurity position and the symmetry of the QWS.Comment: 4 pages, 4 figures, submitted to Phys. Rev. Let

The Piano Improvisations of Chick Corea: An Analytical Study.

Though the number of theoretical studies of jazz has increased in recent years, detailed analysis has been applied to only a small fraction of the body of jazz music. Chick Corea\u27s Piano Improvisations are of particular interest: high quality transcriptions are available, the pieces have never been dealt with in detail, and they embody an intriguing mixture of classical and jazz styles. Analysis of Corea\u27s Piano Improvisations raises issues as to what methods are appropriate in the analysis of jazz. There are currently two, somewhat conflicting, schools of thought. Some believe that analytical techniques traditionally applied to classical music (e.g. motivic and Schenkerian) are inappropriate for use in jazz analysis because the types of relationships sought by these methods are too complex to be created in improvised music. Formulaic analysis is proposed as an approach that takes the improvisation process into account. Others view improvisation as more closely related to composition. Schenkerian theories have been applied to jazz improvisation, giving evidence that the music can contain the same sorts of relationships expected of classical composition. Without denying the value of formulaic analysis, the present study leans in the other direction, focusing on the music as an end product, rather than the process by which it was created. The present study applies traditional formal, harmonic, and motivic analysis to five of Corea\u27s Piano Improvisations, along with reductive techniques related to Schenkerian analysis. The five pieces analyzed are Noon Song, Song for Sally, Ballad for Anna, Song of the Wind, and Sometime Ago. The analytical techniques used prove to be an effective means of considering these pieces. Much is revealed about the nature of the Piano Improvisations including harmonic language that combines elements of jazz and classical music, coherent forms generated largely by variation, and a wide variety of melodic invention based on economical motivic materials. Analysis of the Piano Improvisations points to common elements shared between classical music and jazz, and between composition and improvisation

Increased SK3 expression in DM1 lens cells leads to impaired growth through a greater calcium-induced fragility

Although cataract is a characteristic feature of myotonic dystrophy type 1 (DM1), little is known of the underlying mechanisms. We generated four lens epithelial cell lines derived from DM1 cataracts and two from age-matched, non-DM cataracts. Small-pool PCR revealed typical large triplet repeat expansions in the DM1 cells. Furthermore, real-time PCR analysis showed reduced SIX5 expression and increased expression of the Ca2+-activated K+ channel SK3 in the DM1 cells. These cells also exhibited longer population doubling times which did not arise through reduced proliferation, but rather increased cell death as shown by increased release of lactate dehydrogenase (LDH). Using 86Rb+ as a tracer for K+, we found no difference in the resting K+ influx or efflux kinetics. In all cases, the ouabain sensitive component of the influx contributed ~50% of the total. However, stimulating internal Ca2+ by exposure to ionomycin not only caused greater stimulation of K+ (86Rb) efflux in the DM1 cells but also induced a higher rate of cell death (LDH assay). Since both the hyper-stimulation of K+ efflux and cell death were reduced by the highly specific SK inhibitor apamin, we suggest that increased expression of SK3 has a critical role in the increased Ca2+-induced fragility in DM1 cells. The present data, therefore, both help explain the lower epithelial cell density previously observed in DM1 cataracts and provide general insights into mechanisms underlying the fragility of other DM1-affected tissues

The Impact of National Smoking Prevention Campaigns on Tobacco-Related Beliefs, Intentions to Smoke and Smoking Initiation: Results from a Longitudinal Survey of Youth in the United States

The national truth© campaign has exposed U.S. youth to antismoking messages since 2000. Tobacco industry–sponsored campaigns, such as “Think. Don’t Smoke” (TDS), have also aired nationally. We examine the effects of recall of the truth© and TDS campaigns on changes in tobacco-related beliefs, intentions, and smoking initiation in a longitudinal survey of U.S. youth. Recall of truth© was associated with increased agreement with antismoking beliefs, decreased smoking intentions, and lower rates of smoking initiation. Recall of TDS was associated with increased intentions to smoke soon but was not significantly associated with tobacco beliefs or smoking initiation among youth overall

X-ray radiography of cavitation in a beryllium alloy nozzle

[EN] Making quantitative measurements of the vapor distribution in a cavitating nozzle is difficult, owing to the strong scattering of visible light at gas-liquid boundaries and wall boundaries, and the small lengths and time scales involved. The transparent models required for optical experiments are also limited in terms of maximum pressure and operating life. Over the past few years, x-ray radiography experiments at Argonne's Advanced Photon Source have demonstrated the ability to perform quantitative measurements of the line of sight projected vapor fraction in submerged, cavitating plastic nozzles. In this paper, we present the results of new radiography experiments performed on a submerged beryllium nozzle which is 520m in diameter, with a length/diameter ratio of 6. Beryllium is a light, hard metal that is very transparent to x-rays due to its low atomic number. We present quantitative measurements of cavitation vapor distribution conducted over a range of non-dimensional cavitation and Reynolds numbers, up to values typical of gasoline and diesel fuel injectors. A novel aspect of this work is the ability to quantitatively measure the area contraction along the nozzle with high spatial resolution. Analysis of the vapor distribution, area contraction and discharge coefficients are made between the beryllium nozzle and plastic nozzles of the same nominal geometry. When gas is dissolved in the fuel, the vapor distribution can be quite different from that found in plastic nozzles of the same dimensions, although the discharge coefficients are unaffected. In the beryllium nozzle, there were substantially fewer machining defects to act as nucleation sites for the precipitation of bubbles from dissolved gases in the fuel, and as such the effect on the vapor distribution was greatly reduced.Raul Payri was funded by a Fulbright visiting scholar grant in collaboration with the Ministry of Education, Culture and Sports of Spain (reference PRX14/00331) while performing this work. Juan P Viera was funded by the Spanish MINECO (grant EEBB-I-15-0976 under project TRA2012-36932).Duke, DJ.; Matusik, KE.; Kastengren, AL.; Swantek, AB.; Sovis, N.; Payri, R.; Viera-Sotillo, JP.... (2017). X-ray radiography of cavitation in a beryllium alloy nozzle. International Journal of Engine Research. 18(1-2):39-50. https://doi.org/10.1177/1468087416685965S3950181-

Volunteer Bias in Recruitment, Retention, and Blood Sample Donation in a Randomised Controlled Trial Involving Mothers and Their Children at Six Months and Two Years: A Longitudinal Analysis

BACKGROUND: The vulnerability of clinical trials to volunteer bias is under-reported. Volunteer bias is systematic error due to differences between those who choose to participate in studies and those who do not. METHODS AND RESULTS: This paper extends the applications of the concept of volunteer bias by using data from a trial of probiotic supplementation for childhood atopy in healthy dyads to explore 1) differences between a) trial participants and aggregated data from publicly available databases b) participants and non-participants as the trial progressed 2) impact on trial findings of weighting data according to deprivation (Townsend) fifths in the sample and target populations. 1) a) Recruits (n = 454) were less deprived than the target population, matched for area of residence and delivery dates (n = 6,893) (mean [SD] deprivation scores 0.09[4.21] and 0.79[4.08], t = 3.44, df = 511, p<0.001). b) i) As the trial progressed, representation of the most deprived decreased. These participants and smokers were less likely to be retained at 6 months (n = 430[95%]) (OR 0.29,0.13-0.67 and 0.20,0.09-0.46), and 2 years (n = 380[84%]) (aOR 0.68,0.50-0.93 and 0.55,0.28-1.09), and consent to infant blood sample donation (n = 220[48%]) (aOR 0.72,0.57-0.92 and 0.43,0.22-0.83). ii) Mothers interested in probiotics or research or reporting infants' adverse events or rashes were more likely to attend research clinics and consent to skin-prick testing. Mothers participating to help children were more likely to consent to infant blood sample donation. 2) In one trial outcome, atopic eczema, the intervention had a positive effect only in the over-represented, least deprived group. Here, data weighting attenuated risk reduction from 6.9%(0.9-13.1%) to 4.6%(-1.4-+10.5%), and OR from 0.40(0.18-0.91) to 0.56(0.26-1.21). Other findings were unchanged. CONCLUSIONS: Potential for volunteer bias intensified during the trial, due to non-participation of the most deprived and smokers. However, these were not the only predictors of non-participation. Data weighting quantified volunteer bias and modified one important trial outcome. TRIAL REGISTRATION: This randomised, double blind, parallel group, placebo controlled trial is registered with the International Standard Randomised Controlled Trials Register, Number (ISRCTN) 26287422. Registered title: Probiotics in the prevention of atopy in infants and children

A study on the relationship between internal nozzle geometry and injected mass distribution of eight ECN Spray G nozzles

[EN] Gasoline direct injection (GDI) nozzles are manufactured to meet geometric specifications with length scales on the order of a few hundred microns. The machining tolerances of these nominal dimensions are not always known due to the difficulty in accurately measuring such small length scales in a nonintrusive fashion. To gain insight into the variability of the machined dimensions as well as any effects that this variability may have on the fuel spray behavior, a series of measurements of the internal geometry and fuel mass distribution were performed on a set of eight nominally duplicate GDI “Spray G” nozzles provided by the Engine Combustion Network. The key dimensions of each of the eight nozzle holes were measured with micron resolution using full spectrum x-ray tomographic imaging at the 7-BM beamline of the Advanced Photon Source at Argonne National Laboratory. Fuel density distributions at 2 mm downstream of the nozzle tips were obtained by performing x-ray radiography measurements for many lines of sight. The density measurements reveal nozzle-to-nozzle as well as hole-to-hole density variations. The combination of high-resolution geometry and fuel distribution datasets allows spray phenomena to be linked to specific geometric characteristics of the nozzle, such as variability in the hole lengths and counterbore diameters, and the hole inlet corner radii. This analysis provides important insight into which geometrical characteristics of the nozzles may have the greatest importance in the development of the injected sprays, and to what degree these geometric variations might account for the total spray variability. The goal of this work is then to further the understanding of the relationship between internal nozzle geometry and fuel injection, provide input to improve computational models, and ultimately aid in optimizing injector design for higher fuel efficiency and lower emissions engines.This research was performed at the 7-BM beamline of the APS at Argonne National Laboratory. Use of the APS is supported by the U.S. Department of Energy (DOE) under Contract No. DE-AC02-06CH11357. We gratefully acknowledge the computing resources provided on Blues, a high-performance computing cluster operated by the Laboratory Computing Resource Center at Argonne National Laboratory. We thank Dr. Doga Gürsoy for the use of TomoPy and corresponding user support, as well as Dr. Xianghui Xiao at the APS 2-BM beamline for technical guidance in performing x-ray tomography. Argonne’s x-ray fuel injection research is sponsored by the DOE Vehicle Technologies Program under the direction of Gurpreet Singh and Leo Breton.Matusik, K.; Duke, D.; Sovis, N.; Swantek, A.; Powell, C.; Payri, R.; Vaquerizo, D.... (2017). A study on the relationship between internal nozzle geometry and injected mass distribution of eight ECN Spray G nozzles. En Ilass Europe. 28th european conference on Liquid Atomization and Spray Systems. Editorial Universitat Politècnica de València. 313-320. https://doi.org/10.4995/ILASS2017.2017.4766OCS31332

Scleroderma and related disorders: 223. Long Term Outcome in a Contemporary Systemic Sclerosis Cohort

Background: We have previously compared outcome in two groups of systemic sclerosis (SSc) patients with disease onset a decade apart and we reported data on 5 year survival and cumulative incidence of organ disease in a contemporary SSc cohort. The present study examines longer term outcome in an additional cohort of SSc followed for 10 years. Methods: We have examined patients with disease onset between years 1995 and 1999 allowing for at least 10 years of follow-up in a group that has characteristics representative for the patients we see in contemporary clinical practice. Results: Of the 398 patients included in the study, 252 (63.3%) had limited cutaneous (lc) SSc and 146 (36.7%) had diffuse cutaneous (dc) SSc. The proportion of male patients was higher among the dcSSc group (17.1% v 9.9%, p = 0.037) while the mean age of onset was significantly higher among lcSSc patients (50 ± 13 v 46 ± 13 years ± SD, p = 0.003). During a 10 year follow-up from disease onset, 45% of the dcSSc and 21% of the lcSSc subjects developed clinically significant pulmonary fibrosis, p < 0.001. Among them approximately half reached the endpoint within the first 3 years (23% of dcSSc and 10% of lcSSc) and over three quarters within the first 5 years (34% and 16% respectively). There was a similar incidence of pulmonary hypertension (PH) in the two subsets with a steady rate of increase over time. At 10 years 13% of dcSSc and 15% of lcSSc subjects had developed PH (p=0.558), with the earliest cases observed within the first 2 years of disease. Comparison between subjects who developed PH in the first and second 5 years from disease onset demonstrated no difference in demographic or clinical characteristics, but 5-year survival from PH onset was better among those who developed this complication later in their disease (49% v 24%), with a strong trend towards statistical significance (p = 0.058). Incidence of SSc renal crisis (SRC) was significantly higher among the dcSSc patients (12% v 4% in lcSSc, p = 0.002). As previously observed, the rate of development of SRC was highest in the first 3 years of disease- 10% in dcSSc and 3% in lcSSc. All incidences of clinically important cardiac disease developed in the first 5 years from disease onset (7% in dcSSc v 1% in lcSSc, p < 0.001) and remained unchanged at 10 years. As expected, 10-year survival among lcSSc subjects was significantly higher (81%) compared to that of dcSSc patients (70%, p = 0.006). Interestingly, although over the first 5 years the death rate was much higher in the dcSSc cohort (16% v 6% in lcSSc), over the following years it became very similar for both subsets (14% and 13% between years 5 and 10, and 18% and 17% between years 10 and 15 for dcSSc and lcSSc respectively). Conclusions: Even though dcSSc patients have higher incidence for most organ complications compared to lcSSc subjects, the worse survival among them is mainly due to higher early mortality rate. Mortality rate after first 5 years of disease becomes comparable in the two disease subsets. Disclosure statement: The authors have declared no conflicts of interes

Measurements of droplet size in shear-driven atomization using ultra-small angle x-ray scattering

[EN] Measurements of droplet size in optically-thick, non-evaporating, shear-driven sprays have been made using ultra-small angle x-ray scattering (USAXS). The sprays are produced by orifice-type nozzles coupled to diesel injectors, with measurements conducted from 1 - 24 mm from the orifice, spanning from the optically-dense near-nozzle region to more dilute regions where optical diagnostics are feasible. The influence of nozzle diameter, liquid injection pressure, and ambient density were examined. The USAXS measurements reveal few if any nanoscale droplets, in conflict with a popular computational model of diesel spray breakup. The average droplet diameter rapidly decreases with downstream distance from the nozzle until a plateau value is reached, after which only small changes are seen in droplet diameter. This plateau droplet size is consistent with the droplets being small enough to be stable with respect to further breakup. Liquid injection pressure and nozzle diameter have the biggest impact on droplet size, while ambient density has a smaller effect. (C) 2017 Published by Elsevier Ltd.X-ray spray research at Argonne is supported by the DOE Advanced Combustion Program. We acknowledge team leaders Gurpreet Singh and Leo Breton for their support. These experiments were performed at the 7-BM, 9-ID, and 15-ID beamlines of the Advanced Photon Source, Argonne National Laboratory. ChemMatCARS Sector 15 is principally supported by the Divisions of Chemistry (CHE) and Materials Research (DMR), National Science Foundation, under grant number NSF/CHE-1346572. Use of the Advanced Photon Source, an Office of Science User Facility operated for the U.S. Department of Energy (DOE) Office of Science by Argonne National Laboratory, was supported by the U.S. DOE under Contract No. DE-ACO2-06CH11357. R. Payri was funded by a Fulbright visiting scholar grant in collaboration with the Ministry of Education, Culture and Sports of Spain (reference PRX14/00331) while performing this work. J.P. Viera was funded by the Spanish MINECO grant EEBB-I-15-0976 under project TRA2012-36932.Kastengren, A.; Ilavsky, J.; Viera-Sotillo, JP.; Payri, R.; Duke, DJ.; Swantek, A.; Tilocco, FZ.... (2017). Measurements of droplet size in shear-driven atomization using ultra-small angle x-ray scattering. International Journal of Multiphase Flow. 92:131-139. https://doi.org/10.1016/j.ijmultiphaseflow.2017.03.005S1311399