Long-range dependencies in heart rate signals- revisited

The RR series extracted from human electrocardiogram signal (ECG) is considered as a fractal stochastic process. The manifestation of long-range dependencies is the presence of power laws in scale dependent process characteristics. Exponents of these laws: $\beta$ - describing power spectrum decay, $\alpha$ - responsible for decay of detrended fluctuations or $H$ related to, so-called, roughness of a signal, are known to differentiate hearts of healthy people from hearts with congestive heart failure. There is a strong expectation that resolution spectrum of exponents, so-called, local exponents in place of global exponents allows to study differences between hearts in details. The arguments are given that local exponents obtained in multifractal analysis by the two methods: wavelet transform modulus maxima (WTMM) and multifractal detrended fluctuation analysis (MDFA), allow to recognize the following four stages of the heart: healthy and young, healthy and advance in years, subjects with left ventricle systolic dysfunction (NYHA I--III class) and characterized by severe congestive heart failure (NYHA III-IV class).Comment: 24 page

Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort

Patterns of brain and cardiovascular activation while solving rule-discovery and rule-application numeric tasks

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Platelets in Hepatocellular Carcinoma—From Pathogenesis to Targeted Therapy

Hepatocellular carcinoma (HCC) is a malignancy with a complex pathogenesis, course, and prognosis with increasing incidence. The most significant contributing factor to the development of HCC is the chronic process of inflammation and remodeling of the cirrhotic liver, in which the interaction between the tumor microenvironment (TME) and cancer cells plays a pivotal role. In recent years, increasing focus has been directed toward the role of platelets (PLTs) in mediating interactions between tumor cells and the TME and in the progression and spread of HCC, as well as other cancers. Due to their abundance in the bloodstream and intracellular granules rich in mediators facilitating their ability to modulate the immune system, PLTs play a significant role in carcinogenesis. In the context of HCC, the role of PLTs in the healing and regeneration processes of the liver has been recognized for some time. In recent years, there has been an increasing utilization of PLTs in prognostic models for patients with HCC. Given their role and the availability of clinical options that block PLTs’ action, clinical trials of platelet blockers in the adjunctive treatment of HCC are becoming increasingly common. However, further research, both preclinical and clinical, is necessary to fully elucidate the role of PLTs in HCC and their potential use as a therapeutic target. In this literature review, we summarize the current knowledge on PLTs in HCC and focus on their potential use in everyday clinical practice