A multi-layer agent-based model for the analysis of energy distribution networks in urban areas

Significant research contributions and Directives approach the issue of the insertion of renewable-based energy systems on urban territory in order to face with the growing energy needs of citizens. The introduction of such systems gives raise to installers to both satisfy their energy demands and distribute eventual energy excesses to close neighbours. This paper presents a multi-layer agent-based computational model that simulates multiple event of the network of the energy distribution occurring within urban areas. The model runs on the NetLogo platform and aims at elaborating the most suitable strategy when dealing with the design of a network of energy distribution. Experimental data are discussed on the basis of two main scenarios within an operating period of 24 hours. Scenarios consider both the variation of the percentages of installers of renewable-based energy systems and the distance along which energy exchanges occur.Comment: 22 pages, 15 figure

Natriuretic peptides and cardiovascular damage in the metabolic syndrome. Molecular mechanisms and clinical implications

Natriuretic peptides are endogenous antagonists of vasoconstrictor and salt- and water-retaining systems in the body's defence against blood pressure elevation and plasma volume expansion, through direct vasodilator, diuretic and natriuretic properties. In addition, natriuretic peptides may play a role in the modulation of the molecular mechanisms involved in metabolic regulation and cardiovascular remodelling. The metabolic syndrome is characterized by visceral obesity, hyperlipidaemia, vascular inflammation and hypertension, which are linked by peripheral insulin resistance. Increased visceral adiposity may contribute to the reduction in the circulating levels of natriuretic peptides. The dysregulation of neurohormonal systems, including the renin-angiotensin and the natriuretic peptide systems, may in turn contribute to the development of insulin resistance in dysmetabolic patients. In obese subjects with the metabolic syndrome, reduced levels of natriuretic peptides may be involved in the development of hypertension, vascular inflammation and cardio vascular remodelling, and this may predispose to the development of cardiovascular disease. The present review summarizes the regulation and function of the natriuretic peptide system in obese patients with the metabolic syndrome and the involvement of altered bioactive levels of natriuretic peptides in the pathophysiology of cardiovascular disease in patients with metabolic abnormalities

PINK1 homozygous W437X mutation in a patient with apparent dominant transmission of parkinsonism.

We analyzed the PINK1 gene in 58 patients with early-onset Parkinsonism and detected the homozygous mutation W437X in 1 patient. The clinical phenotype was characterized by early onset (22 years of age), good re- sponse to levodopa, early fluctuations and dyskinesias, and psychiatric symptoms. The mother, heterozygote for W437X mutation, was affected by Parkinson’s disease and 3 further relatives were reported affected, according to an autosomal dominant transmission

Life Monza: project description and actions’ updating

The introduction of Low Emission Zones, urban areas subject to road traffic restrictions in order to ensure compliance with the air pollutants limit values set by the European Directive on ambient air quality (2008/50/EC), is a common and well-established action in the administrative government of cities. The impacts on air quality improvement are widely analysed, whereas the effects and benefits concerning the noise have not been addressed in a comprehensive manner. As a consequence, the definition, the criteria for the analysis and the management methods of a Noise Low Emission Zone are not clearly expressed and shared yet. The LIFE MONZA project (Methodologies fOr Noise low emission Zones introduction And management - LIFE15 ENV/IT/000586) addresses these issues. The first objective of the project, co-funded by the European Commission, is to introduce an easy-replicable method for the identification and the management of the Noise Low Emission Zone, an urban area subject to traffic restrictions, whose impacts and benefits regarding noise issues will be analyzed and tested in the pilot area of the city of Monza, located in Northern Italy. Background conditions, structure, objectives of the project and actions’ progress will be discussed in this article

BASAS: a graphical tool to investigate variability, repeatability and asymmetries in Squat

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Recensione a: Edmund Husserl, La crisi delle scienze europee

Husserl’s “The Crisis of European Sciences and the Transcendental Phenomenology” is more than a simple philosophical treatise. This XX Century’s classic can be read as the German philosopher’s spiritual testament. The present review briefly illustrates the genesis and main topics of the work: the criticism of objectivism, the sciences’ horizon of meaning, the identity and destiny of Europe, the phenomenological method