227 research outputs found
Current Trends in Design and Analysis of Paper Machine Foundations
Current trends in the design and dynamic analysis of paper machine foundations to ensure satisfactory performance are presented in this paper. Space frame foundations for modern high speed paper machines are governed by the requirements to meet stringent alignment/deflection tolerances and dynamic stiffness requirements specified by the machine manufacturer. The current design approach considers the complete machine-foundation-soil interaction. The dynamic response analysis is commonly conducted using a suitable finite element computer code in which the soil is modelled by equivalent springs. Damping is also included in the response calculation. Appropriate stiffness and damping parameters to model the foundation soil or soil/pile system are obtained from complex, frequency-dependent impedance functions derived from analytical and numerical solutions of continuum foundation models. Two case histories are presented to illustrate the use of forced vibration testing to aid in the machine foundation design process
General Report Session 3: Deformation and Liquefaction of Sands, Silt, Gravels and Clays
It has been almost 27 years since the damaging earthquakes of 1964 which occurred in Niigata, Japan and in Alaska, USA, focused the geotechnical engineers\u27 attention to liquefaction as a major problem in earthquake engineering. Considerable research and studies have been conducted on the subject of earthquake induced liquefaction since that time and these have included field observations, laboratory experiments and model tests, and theoretical studies. Progress in understanding the liquefaction phenomenon, in the assessment of liquefaction potential, and in the solutions to mitigate the liquefaction hazard has been made, yet the problem remains controversial in many respects, as reflected by the many stimulating papers presented in this session. The word liquefaction has been associated with many phenomena observed in the field during and after earthquakes such as sand boils, flow slides, lateral spreads, loss of bearing capacity and porewater pressure rise. In laboratory tests, liquefaction has been defined in several ways relating to pore pressure buildup under undrained cyclic straining or loading, or the development of a specified amount of shear strain in a fixed number of cycles of loading. Laboratory studies have also shown that the liquefaction phenomenon can be divided into three different behaviors, namely, true liquefaction, limited liquefaction and cyclic mobility. In theoretical studies, liquefaction occurs when the seismic-induced cyclic shear stress exceeds the cyclic shear resistance, or when the seismic porewater pressure increases to equal the effective stress. To compare the results from different papers, one must bear in mind the different definitions used by the various authors. Liquefaction-caused failure is really the result of excessive permanent deformation, e.g. tilting, settlement or heave of structures, excessive slumping or distortion, and sliding of slopes. Liquefaction-induced ground deformation is receiving more attention in the last decade. Soil failure due to liquefaction was the most dominant cause of damage in the recent M 7. 7 Luzon earthquake of July 16, 1990 in the Philippines. Remedial measures or ground improvement techniques to reduce the liquefaction hazards are becoming more common in recent years, not only for seismic rehabilitation of existing sites but also for newly developed sites. Refinements in equipment and techniques of existing methods are being developed. As well, new methods of ground improvements are being introduced. The M 7.1 Lorna Prieta earthquake of October 17, 1989 showed convincingly that liquefaction hazard can be avoided or effectively mitigated by soil densification prior to earthquake
An Alternative Method of Measuring SPT Energy
Despite problems associated with its repeatability and reliability, the standard Penetration Test (SPT) continues to be the most widely used in-situ test for liquefaction potential assessment. There are many factors known to influence the SPT results but the most significant factor affecting the N value is the amount of hammer energy delivered into the drill rods. The existing method of SPT energy measurement consists of attaching a load cell near the top of the drill rods and measuring the force time history during hammer impact. An alternative method of SPT energy determ1nat1on based on measurement of both force and acceleration time history is described. It is shown that the proposed method is more fundamental and avoids several shortcomings in the existing method. Field measurements are presented and SPT energies calculated by both methods are compared
General Report — Session 5: Case Histories and Failure of Retaining Structures, Slurry Walls, and Deep Foundations
I Am as Incompetent as the Prototypical Group Member: An Investigation of Naturally Occurring Golem Effects in Work Groups
Over four decades, research has demonstrated Pygmalion and Galatea effects (positive expectations leading to high performance) across various settings. In contrast, research on the parallel notion of Golem effects (negative expectations leading to low performance) has been largely overlooked. This study is the first to examine the relationship between group-level Implicit Followership Theories (GIFTs) and naturally occurring Golem effects. Integrating the literature on Implicit Followership Theories, self-fulfilling prophecies, and social identity, we propose that negative GIFTs can serve as proxies of expectations for followers that trigger Golem effects in workgroups. Data from 202 followers and 101 leaders provide support for our hypothesized multi-level model, revealing a top-down relationship between negative GIFTs and follower performance through their self-efficacy and effort. Findings highlight the importance of GIFTs in the Golem process, showing that followers’ cognitions and behaviors are shaped by the group’s prototypical attributes. Suggestions for future research are offered, including interpersonal Golem effects, negative GIFTs and negative outcomes, and influence of organizational culture
Ground Improvement by Dynamic Compaction at a Tailings Disposal Facility
This paper presents two case histories of ground improvement by dynamic compaction (DC) at the Myra Falls mine in Vancouver Island, British Columbia, Canada. Dynamic compaction was employed to densify soils at two sites within the operating mine: a waste rock dump beneath a new processing plant to reduce settlements beneath the structure foundations (Site A); and coarse fluvial and colluvial soils at the toe of an existing tailings embankment to improve seismic resistance against liquefaction (Site B). At Site A, the variable plant loadings required variable compaction energy to achieve uniform foundation performance. At Site B, the foundation soils contained some fine grained soils that dictated a time-controlled sequential DC approach to allow excess pore pressures to dissipate between passes. Because of large uncertainties in the expected performance of DC at both sites, a fair and cost effective DC contract based on unit price per energy was adopted, instead of the traditional performance-based lump sum price contract. This paper describes the ground conditions at the two sites, DC methodologies employed, and ground improvement performance based on measurements of crater volumes and pre- and post-densification in-situ testing by Becker Penetration Tests
Spectrum of PEX1 and PEX6 variants in Heimler syndrome
Heimler syndrome (HS) consists of recessively inherited sensorineural hearing loss, amelogenesis imperfecta (AI) and nail abnormalities, with or without visual defects. Recently HS was shown to result from hypomorphic mutations in PEX1 or PEX6, both previously implicated in Zellweger Syndrome Spectrum Disorders (ZSSD). ZSSD are a group of conditions consisting of craniofacial and neurological abnormalities, sensory defects and multi-organ dysfunction. The finding of HS-causing mutations in PEX1 and PEX6 shows that HS represents the mild end of the ZSSD spectrum, though these conditions were previously thought to be distinct nosological entities. Here, we present six further HS families, five with PEX6 variants and one with PEX1 variants, and show the patterns of Pex1, Pex14 and Pex6 immunoreactivity in the mouse retina. While Ratbi et al. found more HS-causing mutations in PEX1 than in PEX6, as is the case for ZSSD, in this cohort PEX6 variants predominate, suggesting both genes play a significant role in HS. The PEX6 variant c.1802G>A, p.(R601Q), reported previously in compound heterozygous state in one HS and three ZSSD cases, was found in compound heterozygous state in three HS families. Haplotype analysis suggests a common founder variant. All families segregated at least one missense variant, consistent with the hypothesis that HS results from genotypes including milder hypomorphic alleles. The clinical overlap of HS with the more common Usher syndrome and lack of peroxisomal abnormalities on plasma screening suggest that HS may be under-diagnosed. Recognition of AI is key to the accurate diagnosis of HS
Estradiol alters the immune-responsiveness of cervical epithelial cells stimulated with ligands of Toll-like receptors 2 and 4.
The mucosa of the female reproductive tract plays a pivotal role in host defence. Pregnancy must alter immunological mechanisms at this interface to protect the conceptus. We sought to determine how estradiol (E2) alters the immune-responsiveness of cervical epithelial cells to ligand stimulation of Toll-like receptor (TLR)-2 and -4. Human ectocervical epithelial cells (HECECs) were cultured and co-incubated with two concentrations of E2 and peptidoglycan (PGN) or lipopolysaccharide (LPS) over durations that ranged between 10 minutes and 18 hours. Cytometric Bead Array was performed to quantify eight cytokines in the supernatant fluid. In response to PGN, HECECs co-incubated with E2 released lesser quantities of IL-1ß and IFNγ, higher levels of RANTES, and variable levels of IL-6 and IL-8 than those not exposed to E2. In contrast, HECECs co-incubated with LPS and E2 secreted increased levels of IL-1ß, IL-6, IL-8, and IFNγ at 2 and 18 hours than HECECs not exposed to E2, and reduced levels of RANTES at same study time-points. Estradiol alters the immune-responsiveness of cultured HECECs to TLR2 and TLR4 ligands in a complex fashion that appears to vary with bacterial ligand, TLR subtype, and duration of exposure. Our observations are consistent with the functional complexity that this mucosal interface requires for its immunological roles
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