Young people and the evaluation of information on the World Wide Web: Principles, practice and beliefs

A recurrent theme in LIS literature is the tendency of young people not to evaluate rigorously the information with which they come into contact. Although many information literacy models stress the need to take a critical approach, the reality of behaviour is often very different. Recent research conducted in an English high school has explored the importance that teenagers attach to ten particular evaluative criteria. 149 youngsters contributed data via an online questionnaire. Participants felt that information on the Web should be current/topical, free from spelling and grammatical errors and easily verifiable elsewhere but authorship was much less of a priority to them. The findings are likely to be of special relevance to information literacy teachers who are defining priorities for their own programmes

Empowering Developing Countries to Lead the Aid Partnership

human development, aid, trade, security

Economic Impacts of Yellow Starthistle on California Ranchers

While the significant ecosystem damage caused by invasive weeds has been well documented, the economic impacts of specific invasive weed species are poorly understood. Yellow starthistle (Centaurea solstitialis L., hereafter YST) is the most widespread non-crop weed in California, resulting in serious damage to forage on natural range and improved pasture. A survey was administered to California cattle ranchers to investigate YST infestation rates, loss of forage quantity and value, and control or eradication efforts. The results were used to estimate county-wide economic losses for three focus counties, as well as state-wide economic losses, due to YST in California. Total losses of livestock forage value due to YST on private land for the state of California are estimated at $7.96 million/year, with ranchers’ out-of-pocket expenditures on YST control amounting to$9.45 million/year. Together, these costs are the equivalent of 6-7% of the total annual harvested pasture value for the state. Therefore, while the impacts are relatively small within the statewide total agricultural production system, costs due to YST infestation significantly constrain California’s livestock grazing sector.nonnative species, invasive weeds, yellow starthistle, ranching profitability, forage, livestock

Diesel Exhaust Activates & Primes Microglia: Air Pollution, Neuroinflammation, & Regulation of Dopaminergic Neurotoxicity

BACKGROUND: Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood. OBJECTIVES: Here, we sought to address the brain-region-specific effects of diesel exhaust (DE) and key cellular mechanisms underlying DE-induced microglia activation, neuroinflammation, and dopaminergic (DA) neurotoxicity. METHODS: Rats were exposed to DE (2.0, 0.5, and 0 mg/m3) by inhalation over 4 weeks or as a single intratracheal administration of DE particles (DEP; 20 mg/kg). Primary neuron-glia cultures and the HAPI (highly aggressively proliferating immortalized) microglial cell line were used to explore cellular mechanisms. RESULTS: Rats exposed to DE by inhalation demonstrated elevated levels of whole-brain IL-6 (interleukin-6) protein, nitrated proteins, and IBA-1 (ionized calcium-binding adaptor molecule 1) protein (microglial marker), indicating generalized neuroinflammation. Analysis by brain region revealed that DE increased TNFα (tumor necrosis factor-α), IL-1β, IL-6, MIP-1α (macrophage inflammatory protein-1α) RAGE (receptor for advanced glycation end products), fractalkine, and the IBA-1 microglial marker in most regions tested, with the midbrain showing the greatest DE response. Intratracheal administration of DEP increased microglial IBA-1 staining in the substantia nigra and elevated both serum and whole-brain TNFα at 6 hr posttreatment. Although DEP alone failed to cause the production of cytokines and chemokines, DEP (5 μg/mL) pretreatment followed by lipopolysaccharide (2.5 ng/mL) in vitro synergistically amplified nitric oxide production, TNFα release, and DA neurotoxicity. Pretreatment with fractalkine (50 pg/mL) in vitro ameliorated DEP (50 μg/mL)-induced microglial hydrogen peroxide production and DA neurotoxicity. CONCLUSIONS: Together, these findings reveal complex, interacting mechanisms responsible for how air pollution may cause neuroinflammation and DA neurotoxicity

Maybe She Is Relatable Increasing Women’s Awareness of Gender Bias Encourages Their Identification With Women Scientists

In the current research, we explored whether informing women about gender bias in science, technology, engineering, and mathematics (STEM) would enhance their identification with a female scientist and whether this increased identification would in turn protect women from any adverse effects of gender bias information. We found that, relative to a control information condition, gender bias information promoted beliefs that a successful woman (but not a man) scientist had encountered bias and encouraged identification with that woman scientist. Feelings of empathic concern was an important mechanism underlying this increased identification (Experiments 2 and 3). Moreover, when presented with a man scientist, information about gender bias in STEM decreased female participants’ anticipated belonging and trust in a STEM environment, compared to participants in a control information condition (Experiment 1a and 1b). However, identifying with a woman scientist after learning about sexism in STEM fields alleviated this harmful effect. Finally, compared to those in the control condition, women college students who learned about gender bias reported greater interest in interacting with a woman STEM professor at their university (Experiment 3). Our results suggest that interventions that teach women about gender bias in STEM will help women identify with women scientists. Additional online materials for this article are available on PWQ’s website at http://journals.sagepub.com/doi/suppl/10.1177/0361684317752643

Exploring the acceptability of a clinical decision rule to identify paediatric burns due to child abuse or neglect

Objective An evidence based clinical decision rule (CDR) was developed from a systematic review and epidemiological study to identify burns due to child maltreatment (abuse or neglect). Prior to an implementation evaluation, we aim to explore clinicians' views of the CDR, the likelihood that it would influence their management and factors regarding its acceptability. Methods A semistructured questionnaire exploring demographics, views of the CDR and data collection pro forma, ability to recognise maltreatment and likelihood of following CDR recommended child protection (CP) action, was administered to 55 doctors and nurses in eight emergency departments and two burns units. Recognition of maltreatment was assessed via four fictitious case vignettes. Analysis Fisher's exact test and variability measured by coefficient of unalikeability. Results The majority of participants found the CDR and data collection pro forma useful (45/55, 81.8%). Only five clinicians said that they would not take the action recommended by the CDR (5/54, 9.3%). Lower grade doctors were more likely to follow the CDR recommendations (p=0.04) than any other grade, while senior doctors would consider it within their decision making. Factors influencing uptake include: brief training, background to CDR development and details of appropriate actions. Conclusions It is apparent that clinicians are willing to use a CDR to assist in identifying burns due to child maltreatment. However, it is clear that an implementation evaluation must encompass the influential variables identified to maximise uptake

Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1 to S phase transition and identifies a conserved family of proteins

Regulation of cell cycle progression occurs in part through the targeted degradation of both activating and inhibitory subunits of the cyclin-dependent kinases. During G1, CDC4, encoding a WD-40 repeat protein, and CDC34, encoding a ubiquitin-conjugating enzyme, are involved in the destruction of these regulators. Here we describe evidence indicating that CDC53 also is involved in this process. Mutations in CDC53 cause a phenotype indistinguishable from those of cdc4 and cdc34 mutations, numerous genetic interactions are seen between these genes, and the encoded proteins are found physically associated in vivo. Cdc53p defines a large family of proteins found in yeasts, nematodes, and humans whose molecular functions are uncharacterized. These results suggest a role for this family of proteins in regulating cell cycle proliferation through protein degradation